Cancer Systems and Integrative Biology

Häftad, Engelska, 2024

Del i serien Methods in Molecular Biology

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Beskrivning

The chapters, contributed by experts in the areas of cancer systems and integrative biology, provide hands-on guidance toward developing tools to monitor spatial and temporal changes in tumors, tracking tumor markers in blood, and ultimately developing precision medicine to combat cancer in real time.

Produktinformation

Utgivningsdatum:2024-05-18
Mått:178 x 254 x 22 mm
Vikt:735 g
Format:Häftad
Språk:Engelska
Serie:Methods in Molecular Biology
Antal sidor:375
Förlag:Springer-Verlag New York Inc.
ISBN:9781071631652

Utforska kategorier

Onkologi inom Medicin
Biovetenskap inom Naturvetenskap och teknik

Innehållsförteckning

Introduction: Cancer Systems and Integrative Biology.- Genome-Wide Analysis of Palindrome Formation with Next-Generation Sequencing (GAPF-Seq) and a Bioinformatics Pipeline for Assessing De Novo Palindromes in Cancer Genomes.- Sample Preparation and Differential Gene Expression Analysis of Human Cancer Cell Lines by RNA Sequencing.- Generating Mitochondrial-Nuclear Exchange (MNX) Mice to Identify Mitochondrial Determinants of Cancer Metastasis.- 3D Autologous Culture Method for Precision Oncology.- High-Plex Spatial Profiling of RNA and Protein Using Digital Spatial Profiler.- Integration of Single Cell RNA-Sequencing and Network Analysis to Investigate Mechanism of Drug Resistance.- Combination of Tissue Microarray Profiling and Multiplexed IHC Approaches to Investigate Transport Mechanism of Nucleoside Analog Drug Resistance.- In Situ Proximity Ligation Assay to Visualize Protein-Protein Interactions in Tumor Specimens.- Integration of Metabolomic and Proteomic Data to Uncover Actionable Metabolic Pathways.- Linking Expression of Cell-Surface Receptors with Transcription Factors by Computational Analysis of Paired Single-Cell Proteomes and Transcriptomes.- Mass Spectrometry-Based Tissue Imaging of the Tumor Microenvironment.- Multiplexed Immunoassay Using Quantum Dots to Monitor Proteins Secreted from Single Cells at Near-Single Molecule Resolution.- Isolation and Identification of Plasma Extracellular Vesicles Protein Biomarkers.- Discovery of a Hidden Proinflammatory Signaling Proteome Using a Large Scale, Targeted Antibody Microarray Platform.- Multiplex Fluorescent Immunohistochemistry for Preservation of Tumor Microenvironment Architecture and Spatial Relationship of Cells in Tumor Tissues.- Circle Damage Sequencing for Whole-Genome Analysis of DNA Damage.- CRISPR-Directed Gene Editing as a Method to Reduce Chemoresistance in Lung Cancer Cells.- Integrated In Silico Analysis of Proteogenomics and Drug Targets for Pancreatic Cancer Survival.- Advanced Computational Methods to Evaluate Vascular Heterogeneity in Tumor Tissue Based on Single Plane Illumination Microscopy.- Illuminating DEPDC1B in Multi-Pronged Regulation of Tumor Progression.- Single Cell and Spatial Analysis of Emergent Organoid Platforms.- Analysis of Phase-Separated Biomolecular Condensates in Cancer.- Gain-of-Function Variomics and Multi-Omics Network Biology for Precision Medicine.