Patient-Derived Xenografts

Methods and Protocols

AvMohamed I. Saad

Inbunden, Engelska, 2024

Del 2806 i serien Methods in Molecular Biology

2 415 kr

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Beskrivning

After a few chapters examining the evolution of PDXs, tracing their roots and contextualizing their significance in the broader narrative of cancer research, the book continues with methodologies for generating PDXs from diverse clinical tissue samples as well as for utilizing PDXs in various specific cancer types.

Produktinformation

Utgivningsdatum:2024-04-28
Mått:178 x 254 x 20 mm
Vikt:685 g
Format:Inbunden
Språk:Engelska
Serie:Methods in Molecular Biology
Antal sidor:244
Upplaga:2024
Förlag:Springer-Verlag New York Inc.
ISBN:9781071638576

Utforska kategorier

Onkologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin

Innehållsförteckning

Patient-Derived Xenografts: Historical Evolution, Immunocompromised Host Models, and Translational Significance.- Patient-Derived Xenograft Models in Cancer Research: Methodology, Applications, and Future Prospects.- Patient-Derived Xenografts: A Valuable Preclinical Model for Drug Development and Biomarker Discovery.- Patient-Derived Xenograft Models for Leukemias.- Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain Cancers.- Generation of Orthotopic and Subcutaneous Patient-Derived Xenograft Models from Diverse Clinical Tissue Samples of Pediatric Extracranial Solid Tumors.- Development of Orthotopic Patient-Derived Xenograft Models of Pediatric Intracranial Tumors.- A Humanized Patient-Derived Xenograft Model for Pancreatic Cancer.- Development and Expansion of Patient-Derived Xenografts for Endometrial Cancer.- A Multiplexed Approach to Assess Small Cell Lung Cancer Subtype Heterogeneity in Primary and Patient-Derived Tumor Samples.- Generation of Metastatic Cholangiocarcinoma Patient-Derived Xenograft Models.- Patient-Derived Xenograft Models for Translational Prostate Cancer Research and Drug Development.- Patient-Derived Xenograft Models for Ovarian Cancer.- Orthotopic MC-38 Allograft as a Robust Preclinical Model of Colorectal Carcinoma.- Assessing Protein Expression in Patient-Derived Xenografts Using Western Blotting.- Analysis of Protein Interactions in Patient-Derived Xenografts Using Immunoprecipitation.- A Semi-Automated Proteomics and Phosphoproteomics Protocol for the Identification of Novel Therapeutic Targets and Predictive Biomarkers in In Vivo Xenograft Models of Pediatric Cancers.