TAHIRA FAROOQUI has published extensively on drug receptor interactions, biogenic amines in vertebrate and invertebrate nervous systems, glycerophospholipid and sphingolipid metabolism, and molecular mechanisms in the brain, as well as on the neuromodulatory role of octopamine in the reinforcement pathway involved in olfactory learning and memory. AKHLAQ A. FAROOQUI is a leader in the fields of signal transduction, brain phospholipase A2, bioactive ether lipid metabolism, and polyunsaturated fatty acid metabolism, among others. Farooqui has published on the generation and identification of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid-mediated neurotoxicity by lipidomics.

• PREFACE xiTahira Farooqui and Akhlaq A. Farooqui FOREWORD xiiiGrace Y. SunACKNOWLEDGMENTS xvTahira Farooqui and Akhlaq A. FarooquiCONTRIBUTORS xviiPART I OXIDATIVE STRESS IN VERTEBRATES1 Generation of Reactive Oxygen Species in the Brain: Signaling for Neural Cell Survival or Suicide 3Akhlaq A. Farooqui2 Free Radicals, Signal Transduction, and Human Disease 17Klaudia Jomova and Marian Valko3 Oxidative Stress and its Biochemical Consequences in Mitochondrial DNA Mutation-Associated Diseases: Implications of Redox Therapy for Mitochondrial Diseases 33Shi-Bei Wu, Yu-Ting Wu, Yi-Shing Ma, and Yau-Huei Wei4 Oxidative Stress in Kainic Acid Neurotoxicity: Implications for the Pathogenesis of Neurotraumatic and Neurodegenerative Diseases 51Akhlaq A. Farooqui5 Survival Strategy and Disease Pathogenesis According to the Nrf2-Small Maf Heterodimer 63Masanobu Morita and Hozumi Motohashi6 Caloric Restriction and Oxidative Stress 83Jan Škrha7 Pathogenesis of Neurodegenerative Diseases: Contribution of Oxidative Stress and Neuroinflammation 103Tahira Farooqui and Akhlaq A. Farooqui8 Neurosteroids in Oxidative Stress-Mediated Injury in Alzheimer Disease 117Amandine Grimm, Ayikoe Guy Mensah-Nyagan, and Anne Eckert9 Oxidative Stress in Adult Neurogenesis and in the Pathogenesis of Alzheimer Disease 129Philippe Taupin10 Oxidative Stress and Parkinson Disease 139Kah-Leong Lim, Doyle Graham, and Xiao-Hui Ng11 Oxidative Stress in Cardiovascular Diseases 153Michael E. Andrades and Rodrigo Lorenzi12 Oxidative Stress and Aging: A Comparison between Vertebrates and Invertebrates 167Syed Ibrahim Rizvi and Kanti Bhooshan Pandey13 Oxidative Stress-Mediated Signaling Pathways by Environmental Stressors 175Hideko Sone and Hiromi Akanuma14 Selenoproteins in Cellular Redox Regulation and Signaling 195Arjun V. Raman and Marla J. Berry15 Antioxidant Therapy and its Effectiveness in Oxidative Stress-Mediated Disorders 209Tommaso Iannitti and Beniamino Palmieri16 The Protective Role of Grape Seed Polyphenols Against Oxidative Stress in Treating Neurodegenerative Diseases 235Giulio Maria Pasinetti17 Pharmacological and Therapeutic Properties of Propolis (Bee Glue) 245Kandangath Raghavan Anilakumar, Farhath Khanum, and Amarinder Singh BawaPART II OXIDATIVE STRESS IN INVERTEBRATES18 Endocrine Control of Oxidative Stress in Insects 261Natraj Krishnan and Dalibor Kodri´k19 Oxidative Stress in the Airway System of the Fruit Fly Drosophila melanogaster 271Thomas Roeder20 Molecular Mechanisms of Antioxidant Protective Processes in Honeybee Apis mellifera 279Alexey G. Nikolenko, Elena S. Saltykova, and Louisa R. Gaifullina21 Molecular Basis of Iron-induced Oxidative Stress in the Honeybee Brain: A Potential Model System of Olfactory Dysfunction in Neurological Diseases 295Tahira Farooqui22 Modulation of Oxidative Stress by Keap1/Nrf2 Signaling in Drosophila: Implications for Human Diseases 309Gerasimos P. Sykiotis, M. Mahidur Rahman, and Dirk Bohmann23 Orchestration of Oxidative Stress Responses in Drosophila melanogaster: A Promoter Analysis Study of Circadian Regulatory Motifs 327Kuntol Rakshit and Natraj Krishnan24 The Protective Role of Sestrins Against Chronic TOR Activation and Oxidative Stress 337Jun Hee Lee and Ethan Bier25 Current Advances in the Studies of Oxidative Stress and Age-Related Memory Impairment in C. elegans 347Shin Murakami, Kelly Cabana, and Danielle Anderson26 Oxidative Challenge and Redox Sensing in Mollusks: Effects of Natural and Anthropic Stressors 361Julie Letendre, Franc¸ois Leboulenger, and Fabrice Durand27 Perspective and Directions for Future Studies 377Tahira Farooqui and Akhlaq A. FarooquiINDEX 385