Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency—Energy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.

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• Contributors vii Preface ixStructure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles 1Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin GriffinPhysiopathological Roles of Human Transglutaminase 2 47Vittorio GentileTransglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate 97Guylaine Hoffner, Amandine VanHoutteghem, William Andre, and Philippe DjianTransglutaminase 2: A New Paradigm for NF-B Involvement in Disease 161Soo-Youl KimTransglutaminase 2 At the Crossroads between Cell Death and Survival 197Mauro Piacentini, Manuela D’Eletto, Laura Falasca, Maria Grazia Farrace, and Carlo RodolfoTissue Transglutaminase and Its Role in Human Cancer Progression 247Bo Li, Richard A. Cerione, and Marc AntonyakTransglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2−/−Mouse 295Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and Laszlo FesusEffects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347Zoltan NemesTransglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE, Oksana Lockridge, and Athar H. ChishtiIrreversible Inhibitors of Tissue Transglutaminase 415Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane, and Christophe PardinMethionine Adenosyltransferase (S-Adenosylmethionine Synthetase) 449Marıa A. Pajares and George D. MarkhamIndex 523

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency—Energy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.

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• Contributors vii Preface ixStructure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles 1Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin GriffinPhysiopathological Roles of Human Transglutaminase 2 47Vittorio GentileTransglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate 97Guylaine Hoffner, Amandine VanHoutteghem, William Andre, and Philippe DjianTransglutaminase 2: A New Paradigm for NF-B Involvement in Disease 161Soo-Youl KimTransglutaminase 2 At the Crossroads between Cell Death and Survival 197Mauro Piacentini, Manuela D’Eletto, Laura Falasca, Maria Grazia Farrace, and Carlo RodolfoTissue Transglutaminase and Its Role in Human Cancer Progression 247Bo Li, Richard A. Cerione, and Marc AntonyakTransglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2−/−Mouse 295Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and Laszlo FesusEffects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347Zoltan NemesTransglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE, Oksana Lockridge, and Athar H. ChishtiIrreversible Inhibitors of Tissue Transglutaminase 415Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane, and Christophe PardinMethionine Adenosyltransferase (S-Adenosylmethionine Synthetase) 449Marıa A. Pajares and George D. MarkhamIndex 523

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency—Energy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.

Select Guide Rating

• Contributors vii Preface ixStructure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles 1Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin GriffinPhysiopathological Roles of Human Transglutaminase 2 47Vittorio GentileTransglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate 97Guylaine Hoffner, Amandine VanHoutteghem, William Andre, and Philippe DjianTransglutaminase 2: A New Paradigm for NF-B Involvement in Disease 161Soo-Youl KimTransglutaminase 2 At the Crossroads between Cell Death and Survival 197Mauro Piacentini, Manuela D’Eletto, Laura Falasca, Maria Grazia Farrace, and Carlo RodolfoTissue Transglutaminase and Its Role in Human Cancer Progression 247Bo Li, Richard A. Cerione, and Marc AntonyakTransglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2−/−Mouse 295Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and Laszlo FesusEffects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347Zoltan NemesTransglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE, Oksana Lockridge, and Athar H. ChishtiIrreversible Inhibitors of Tissue Transglutaminase 415Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane, and Christophe PardinMethionine Adenosyltransferase (S-Adenosylmethionine Synthetase) 449Marıa A. Pajares and George D. MarkhamIndex 523