Professor Ivan Capek is author and co-author of 3 scientific books and 20 chapters, 20 review articles, ca.170 articles with and 1000 citations and more than 20 patents. He is Head of the Department at the Polymer Institute, Slovak Academy of Sciences, Bratislava, Slovakia.

• Acknowledgement ixPreface xi1 Introduction 12 Nucleic Acids 292.1 DNA/RNA Basics 292.2 Aptamers, Telomers and Oligonucleotides 502.3 Techniques and Approaches 632.4 DNA-Based Molecular Nanomachines 902.5 Peptide Nucleic Acid 1042.6 Nanobiotechnology 1123 Noble Metal Nanoparticles 1213.1 Preparation and Modification 1213.2 Optical and Physical Properties 1373.3 Conjugates 1444 DNA-Based Conjugates 1494.1 General 1494.2 Condensation 1524.3 Conjugates 1705 DNA-Noble Metal Nanoparticle Conjugates 1735.1 General Approaches 1735.2 DNA Monomers and Oligomers 1785.2.1 Gold Nanoparticles 1785.2.2 Silver Nanoparticles 2075.3 Hybridization and Denaturation 2245.4 DNA Biotemplates 2736 DNA-Gold Nanoparticle Conjugates 2816.1 DNA-Gold Zero-Dimensional Nanoparticle Conjugates 2816.2 DNA One-Dimensional Gold Nanoparticle Conjugates 2957 PNA-Noble Metal Nanoparticles Conjugates 3157.1 PNA-Gold Nanoparticle Conjugates 3157.2 PNA-Silver Nanoparticle Conjugates 3288 DNA-Silver Nanoparticles Conjugates 3359 The Structure of DNA-Noble Metal Nanoparticles Conjugates 3459.1 Configuration of DNA-Noble Metal Nanoparticles Conjugates 3459.2 Stabilization of DNA Conjugates 3589.3 Nanostructures and Nanoconstructs 3699.4 Colorimetric and Sensing Assays 38510 Photochemical and Photophysical Events 40310.1 Noble Metal Nanoparticles 40310.2 DNA Nucleobases 40610.3 DNA/PNA 41710.4 DNA-Dyes Conjugates 42910.5 DNA-AuNP-Dye Conjugates 44310.6 DNA-Gold Nanoparticle Conjugates 45510.7 DNA-AgNPs 46510.8 Hot Gold Nanoparticles 47511 Nanoparticle Therapeutics 48111.1 Biodecorated Nanoparticle-Based Therapies 48111.2 Photothermal Therapy 48911.3 Cells 49511.4 Gene Therapy 49911.5 Blood Fluid Effect 50511.6 Other Application Approaches 50712 Conclusion 515Nomenclature 533DNA Entities 545Vocabulary and Definitions 549References 564Index

Professor Ivan Capek is author and co-author of 3 scientific books and 20 chapters, 20 review articles, ca.170 articles with and 1000 citations and more than 20 patents. He is Head of the Department at the Polymer Institute, Slovak Academy of Sciences, Bratislava, Slovakia.

• Acknowledgement ixPreface xi1 Introduction 12 Nucleic Acids 292.1 DNA/RNA Basics 292.2 Aptamers, Telomers and Oligonucleotides 502.3 Techniques and Approaches 632.4 DNA-Based Molecular Nanomachines 902.5 Peptide Nucleic Acid 1042.6 Nanobiotechnology 1123 Noble Metal Nanoparticles 1213.1 Preparation and Modification 1213.2 Optical and Physical Properties 1373.3 Conjugates 1444 DNA-Based Conjugates 1494.1 General 1494.2 Condensation 1524.3 Conjugates 1705 DNA-Noble Metal Nanoparticle Conjugates 1735.1 General Approaches 1735.2 DNA Monomers and Oligomers 1785.2.1 Gold Nanoparticles 1785.2.2 Silver Nanoparticles 2075.3 Hybridization and Denaturation 2245.4 DNA Biotemplates 2736 DNA-Gold Nanoparticle Conjugates 2816.1 DNA-Gold Zero-Dimensional Nanoparticle Conjugates 2816.2 DNA One-Dimensional Gold Nanoparticle Conjugates 2957 PNA-Noble Metal Nanoparticles Conjugates 3157.1 PNA-Gold Nanoparticle Conjugates 3157.2 PNA-Silver Nanoparticle Conjugates 3288 DNA-Silver Nanoparticles Conjugates 3359 The Structure of DNA-Noble Metal Nanoparticles Conjugates 3459.1 Configuration of DNA-Noble Metal Nanoparticles Conjugates 3459.2 Stabilization of DNA Conjugates 3589.3 Nanostructures and Nanoconstructs 3699.4 Colorimetric and Sensing Assays 38510 Photochemical and Photophysical Events 40310.1 Noble Metal Nanoparticles 40310.2 DNA Nucleobases 40610.3 DNA/PNA 41710.4 DNA-Dyes Conjugates 42910.5 DNA-AuNP-Dye Conjugates 44310.6 DNA-Gold Nanoparticle Conjugates 45510.7 DNA-AgNPs 46510.8 Hot Gold Nanoparticles 47511 Nanoparticle Therapeutics 48111.1 Biodecorated Nanoparticle-Based Therapies 48111.2 Photothermal Therapy 48911.3 Cells 49511.4 Gene Therapy 49911.5 Blood Fluid Effect 50511.6 Other Application Approaches 50712 Conclusion 515Nomenclature 533DNA Entities 545Vocabulary and Definitions 549References 564Index

Professor Ivan Capek is author and co-author of 3 scientific books and 20 chapters, 20 review articles, ca.170 articles with and 1000 citations and more than 20 patents. He is Head of the Department at the Polymer Institute, Slovak Academy of Sciences, Bratislava, Slovakia.

• Acknowledgement ixPreface xi1 Introduction 12 Nucleic Acids 292.1 DNA/RNA Basics 292.2 Aptamers, Telomers and Oligonucleotides 502.3 Techniques and Approaches 632.4 DNA-Based Molecular Nanomachines 902.5 Peptide Nucleic Acid 1042.6 Nanobiotechnology 1123 Noble Metal Nanoparticles 1213.1 Preparation and Modification 1213.2 Optical and Physical Properties 1373.3 Conjugates 1444 DNA-Based Conjugates 1494.1 General 1494.2 Condensation 1524.3 Conjugates 1705 DNA-Noble Metal Nanoparticle Conjugates 1735.1 General Approaches 1735.2 DNA Monomers and Oligomers 1785.2.1 Gold Nanoparticles 1785.2.2 Silver Nanoparticles 2075.3 Hybridization and Denaturation 2245.4 DNA Biotemplates 2736 DNA-Gold Nanoparticle Conjugates 2816.1 DNA-Gold Zero-Dimensional Nanoparticle Conjugates 2816.2 DNA One-Dimensional Gold Nanoparticle Conjugates 2957 PNA-Noble Metal Nanoparticles Conjugates 3157.1 PNA-Gold Nanoparticle Conjugates 3157.2 PNA-Silver Nanoparticle Conjugates 3288 DNA-Silver Nanoparticles Conjugates 3359 The Structure of DNA-Noble Metal Nanoparticles Conjugates 3459.1 Configuration of DNA-Noble Metal Nanoparticles Conjugates 3459.2 Stabilization of DNA Conjugates 3589.3 Nanostructures and Nanoconstructs 3699.4 Colorimetric and Sensing Assays 38510 Photochemical and Photophysical Events 40310.1 Noble Metal Nanoparticles 40310.2 DNA Nucleobases 40610.3 DNA/PNA 41710.4 DNA-Dyes Conjugates 42910.5 DNA-AuNP-Dye Conjugates 44310.6 DNA-Gold Nanoparticle Conjugates 45510.7 DNA-AgNPs 46510.8 Hot Gold Nanoparticles 47511 Nanoparticle Therapeutics 48111.1 Biodecorated Nanoparticle-Based Therapies 48111.2 Photothermal Therapy 48911.3 Cells 49511.4 Gene Therapy 49911.5 Blood Fluid Effect 50511.6 Other Application Approaches 50712 Conclusion 515Nomenclature 533DNA Entities 545Vocabulary and Definitions 549References 564Index