Laurence J. N. Cooper, Associate Professor, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, USA. Elizabeth A. Mittendorf, Professor, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. Judy Moyes, Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, USA. Sabitha Prabhakaran, Clinical Research Scientist, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.

• Editors viContributors viiIntroduction ix1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer 1Saranya Chumsri and Keith L. Knutson2 Monoclonal Antibody Therapy 12Elizabeth A. Mittendorf and Sabitha Prabhakaran3 Somatic Mutations and Immunotherapy 24Eric Tran4 Checkpoint Blockade 37Tracy A. Proverbs‐Singh Jedd Wolchok and Alexandra Snyder5 Myeloid Leukemia Vaccines 54Paul M. Armistead and Jonathan S. Serody6 Cancer Vaccines for Solid Tumors 72Timothy J. Vreeland Garth S. Herbert and George E. Peoples7 Immunotherapy with Non–Genetically Modified T Cells 91Cassian Yee8 Immunotherapy with Genetically Modified T Cells 101Liora Schultz and Crystal Mackall9 Immunomodulation with Adjuvants and Cytokines 115Dae won Kim and Adi Diab10 Immune Cell Migration in Cancer and Immunotherapy 132Timothy Murray and Daniel E. Speiser11 Repurposing of Drugs for Immunotherapy 143Jyothishmathi Swaminathan and Vidya Gopalakrishnan12 Immunomodulation with Radiation 161Jonathan E. Schoenhals Taylor R. Cushman, Alexandra P. Cadena Sandra Demaria and James W. Welsh13 Good Manufacturing Practices Facilities for Cellular Therapy 177Andrew D. Fesnak and Bruce L. Levine14 T Cell Receptor Mimic Antibodies 186Gheath Alatrash and Jeffrey J. Molldrem15 Stem Cell Transplantation for Treatment of Malignancy 201Lohith S. Bachegowda and Richard E. Champlin16 Natural Killer Cell–Based Immunotherapy 215Jennifer A. Foltz Jeffrey S. Miller and Dean A. Lee17 Immunologic Monitoring in Immuno‐Oncology 228William R. Gwin and Mary L. Disis18 Cell‐Based Therapies for Canine Cancer 252Nicola J. Mason and M. Kazim Panjwani19 Interaction between Targeted Therapy and Immunotherapy 268Peter A. Prieto Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. WargoIndex 286

Laurence J. N. Cooper, Associate Professor, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, USA. Elizabeth A. Mittendorf, Professor, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. Judy Moyes, Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, USA. Sabitha Prabhakaran, Clinical Research Scientist, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.

• Editors viContributors viiIntroduction ix1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer 1Saranya Chumsri and Keith L. Knutson2 Monoclonal Antibody Therapy 12Elizabeth A. Mittendorf and Sabitha Prabhakaran3 Somatic Mutations and Immunotherapy 24Eric Tran4 Checkpoint Blockade 37Tracy A. Proverbs‐Singh Jedd Wolchok and Alexandra Snyder5 Myeloid Leukemia Vaccines 54Paul M. Armistead and Jonathan S. Serody6 Cancer Vaccines for Solid Tumors 72Timothy J. Vreeland Garth S. Herbert and George E. Peoples7 Immunotherapy with Non–Genetically Modified T Cells 91Cassian Yee8 Immunotherapy with Genetically Modified T Cells 101Liora Schultz and Crystal Mackall9 Immunomodulation with Adjuvants and Cytokines 115Dae won Kim and Adi Diab10 Immune Cell Migration in Cancer and Immunotherapy 132Timothy Murray and Daniel E. Speiser11 Repurposing of Drugs for Immunotherapy 143Jyothishmathi Swaminathan and Vidya Gopalakrishnan12 Immunomodulation with Radiation 161Jonathan E. Schoenhals Taylor R. Cushman, Alexandra P. Cadena Sandra Demaria and James W. Welsh13 Good Manufacturing Practices Facilities for Cellular Therapy 177Andrew D. Fesnak and Bruce L. Levine14 T Cell Receptor Mimic Antibodies 186Gheath Alatrash and Jeffrey J. Molldrem15 Stem Cell Transplantation for Treatment of Malignancy 201Lohith S. Bachegowda and Richard E. Champlin16 Natural Killer Cell–Based Immunotherapy 215Jennifer A. Foltz Jeffrey S. Miller and Dean A. Lee17 Immunologic Monitoring in Immuno‐Oncology 228William R. Gwin and Mary L. Disis18 Cell‐Based Therapies for Canine Cancer 252Nicola J. Mason and M. Kazim Panjwani19 Interaction between Targeted Therapy and Immunotherapy 268Peter A. Prieto Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. WargoIndex 286

Laurence J. N. Cooper, Associate Professor, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, USA. Elizabeth A. Mittendorf, Professor, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. Judy Moyes, Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, USA. Sabitha Prabhakaran, Clinical Research Scientist, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.

• Editors viContributors viiIntroduction ix1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer 1Saranya Chumsri and Keith L. Knutson2 Monoclonal Antibody Therapy 12Elizabeth A. Mittendorf and Sabitha Prabhakaran3 Somatic Mutations and Immunotherapy 24Eric Tran4 Checkpoint Blockade 37Tracy A. Proverbs‐Singh Jedd Wolchok and Alexandra Snyder5 Myeloid Leukemia Vaccines 54Paul M. Armistead and Jonathan S. Serody6 Cancer Vaccines for Solid Tumors 72Timothy J. Vreeland Garth S. Herbert and George E. Peoples7 Immunotherapy with Non–Genetically Modified T Cells 91Cassian Yee8 Immunotherapy with Genetically Modified T Cells 101Liora Schultz and Crystal Mackall9 Immunomodulation with Adjuvants and Cytokines 115Dae won Kim and Adi Diab10 Immune Cell Migration in Cancer and Immunotherapy 132Timothy Murray and Daniel E. Speiser11 Repurposing of Drugs for Immunotherapy 143Jyothishmathi Swaminathan and Vidya Gopalakrishnan12 Immunomodulation with Radiation 161Jonathan E. Schoenhals Taylor R. Cushman, Alexandra P. Cadena Sandra Demaria and James W. Welsh13 Good Manufacturing Practices Facilities for Cellular Therapy 177Andrew D. Fesnak and Bruce L. Levine14 T Cell Receptor Mimic Antibodies 186Gheath Alatrash and Jeffrey J. Molldrem15 Stem Cell Transplantation for Treatment of Malignancy 201Lohith S. Bachegowda and Richard E. Champlin16 Natural Killer Cell–Based Immunotherapy 215Jennifer A. Foltz Jeffrey S. Miller and Dean A. Lee17 Immunologic Monitoring in Immuno‐Oncology 228William R. Gwin and Mary L. Disis18 Cell‐Based Therapies for Canine Cancer 252Nicola J. Mason and M. Kazim Panjwani19 Interaction between Targeted Therapy and Immunotherapy 268Peter A. Prieto Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. WargoIndex 286