Perinatal Stem Cells

Inbunden, Engelska, 2013

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Beskrivning

Perinatal Stem Cells, 2nd Edition builds on the first edition to provide an updated tutorial on perinatal stem cells, including stem cells harvested from the amniotic fluid, placenta, maternal blood supply, umbilical cord and Wharton's Jelly. As in the first edition, coverage includes the underlying biology of each of the sources of pregnancy related stem cells, cell culture, and potential therapeutic uses, as well as insights on the impact of these stem cells from obstetricians and gynecologists, cardiologists, hematologists, tissue engineers, and cord blood bankers. Normally discarded as medical waste, perinatal stem cells offer a powerful therapeutic tool box alternative to the controversial embryonic stem cells. Since publication of the first edition, a burgeoning commerical industry has developed around various sources of perinatal cells, and the second edition now includes an overview of this growing industry.With contributions from some of the top academic stem cell laboratories in the United States as well as new chapters from international stem cell scientists, Perinatal Stem Cells presents an update on the cutting-edge research in the field while maintaining its signature clinical focus.

Produktinformation

Utgivningsdatum:2013-04-23
Mått:180 x 254 x 23 mm
Vikt:726 g
Format:Inbunden
Språk:Engelska
Antal sidor:320
Upplaga:2
Förlag:John Wiley and Sons Ltd
ISBN:9781118209448

Utforska kategorier

Olycksfalls- och akutmedicin inom Medicin
Anatomi inom Medicin

Mer om författaren

Kyle J. Cetrulo is the founder and CEO of Auxocell Laboraties, Inc, as well as the founder and Director of the Perinatal Stem Cell Society.?Co-editor of the first edition of Perinatal Stem Cells, Dr. Cetrulo is an active member of the stem cell research community, serving as Director of the International Cord Blood Society since 1998. Curtis Cetrulo Jr., M.D. is Assistant Professor of Surgery at Harvard Medical School, Boston. A co-editor of the first edition of Perinatal Stem Cells, he is also Director of the Reconstructive Transplantation Service in the Divisions of Transplant Surgery and Plastic and Reconstructive Surgery at Massachusetts General Hospital, and a senior investigator for the Composite Tissue Allograft Laboratory at Massachusetts General.

Recensioner i media

“A classic text, focuses on recent research and advances in the clinical use of mesenchyme stem cells from pregnancy sources.” (Pediatric Endocrinology Reviews, 1 June 2014)

Innehållsförteckning

Contributors xiIntroduction xv1 AMNIOTIC FLUID STEM CELLS 1Sean Vincent Murphy and Anthony AtalaIntroduction 1Development of Gestational Stem Cells 2Isolation and Characterization of Amniotic Fluid Stem Cells 2Multipotency of Amniotic Fluid Stem Cells 3Clinical Application of Amniotic Fluid Stem Cells 8Conclusion 13References 132 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE 17Richard L. Haspel and Karen K. BallenIntroduction 17Hematopoietic Stem Cell Transplants: Adult Donor Collection 17Hematopoietic Stem Cell Transplants: HLA Matching 18Collection and Processing of Cord Blood Units 19Hematopoietic Stem Cell Transplants: Recipient Issues 20Bone Marrow versus Single Cord Blood: Pediatric 21Bone Marrow versus Cord Blood: Adults 23Cord Blood Transplant: Advantages and Disadvantages 23Double Cord Blood Transplants: Ablative Regimens 24Double Cord Blood Transplant: Non-Myeloablative Regimens 26Are Two Cords Better Than One? 27Chimerism 28Predicting the Winner 28Other Experimental Strategies 30Summary 31References 313 HEMATOPOIETIC STEM CELL DEVELOPMENT IN THE PLACENTA 37Katrin E.R. Ericson, Akanksha Chhabra, and Hanna K.A. MikkolaIntroduction 37The Hematopoietic System 37Historical Perspective on Placental Hematopoiesis 38The Development and Structure of the Mouse Placenta 39Hematopoietic Activity in the Mouse Placenta 40Identification of Placental HSCs 42The Origin and Localization of Placental HSCs 43Hematopoietic Activity in the Human Placenta 45Hematopoietic Microenvironment in the Placenta 46Conclusions and Perspectives 47References 494 PERINATAL MESENCHYMAL STEM CELL BANKING FOR UMBILICAL CORD BLOOD TRANSPLANTATION AND REGENERATIVE MEDICINE 53Rouzbeh R. TaghizadehIntroduction 53Hematopoiesis 54Hematopoietic Transplantations 54Umbilical Cord: Source of Perinatal HSCs and MSCs 56Hematopoietic Transplantations of Umbilical Cord Blood 57Strategies to Overcome the Transplant-Related Limitations of Umbilical Cord Blood 58Umbilical Cord Tissue MSC Banking 61References 635 MAKING ORGAN AND STEM CELL TRANSPLANTATION SAFER: THE ROLE OF MESENCHYMAL STEM CELLS 71Hans KlingemannIntroduction 71MSC to Prevent Rejection After Solid Organ Transplantation 72MSC in the Treatment of Graft-versus-Host Disease 73MSC to Support Hematopoietic Recovery of Stem Cells After Stem Cell Transplantation 74References 756 WHARTON’S JELLY MESENCHYMAL STEM CELLS AND IMMUNE MODULATION: REGENERATIVE MEDICINE MEETS TISSUE REPAIR 77Rita Anzalone, Felicia Farina, Melania Lo Iacono, Simona Corrao, Tiziana Corsello, Giovanni Zummo, and Giampiero La RoccaIntroduction 77Expression of Relevant Immunomodulatory Molecules in Vitro by MSCs 79Tolerance Induction by MSCs: Rediscovering the Embryo Immune Evasion Mechanisms 79Immune Modulation in Vivo: Contrasting Data on the Immune Privilege of MSCs 80WJ-MSC in in Vivo Models: Enhancing the Immunomodulatory Features of Adult MSC Populations 82Conclusions and Future Perspectives 83References 847 IMMUNOGENICITY VERSUS IMMUNOMODULATION OF PERINATAL STEM CELLS 89Bram Lutton and Raimon Duran-StruuckIntroduction 89Mechanisms of Immunomodulation by Umbilical Cord- and Bone Marrow-Derived MSCs 90Innate Immune System 90Adaptive Immune System 92Natural Tolerance and Umbilical Cord Tissues 94Tolerance versus Immunogenicity: The Yin and Yang of Host Responses to Umbilical Cord-Derived Cells 95Conclusions 97References 988 THE TRANSLATIONAL POTENTIAL OF PERINATAL STEM CELLS IN CLINICAL MEDICINE: MESENCHYMAL STEM CELLS 105Radbeh Torabi, Vincenzo Villani, Christopher A. Mallard, and Curtis L. Cetrulo, Jr.Introduction 105Graft-versus-Host Disease 106Acute GVHD 107Chronic GVHD 108GVHD Prevention 109Hematopoetic Recovery and HCT Engraftment 109Hematopoietic Recovery 110HCT Engraftment 111MSC Potential Uses 111References 1139 NEWBORN STEM CELLS: IDENTITY, FUNCTION, AND CLINICAL POTENTIAL 119Anthony Park, Louis Chan, Mayur Danny I. Gohel, Sean Murphy, Ursula Manuelpillai, Ann Chidgey, and Richard BoydIntroduction 120The Newborn Offers an Enormous Opportunity for Stem Cells 120Amnion 120Isolation and Phenotypic Characterization of Amnion Cells 121Therapeutic Potential of Amnion Membrane 123Mechanisms of AEC-Enhanced Wound Repair 125Therapeutic Potential of Amnion as Single Cells 127Amnion Immunogenicity and Immunosuppressive Properties 127Amnion-Derived Mesenchymal Stromal Cells 128Umbilical Cord Mesenchymal Stromal Cells 130Chorion MSCs 131References 13310 BIOMEDICAL POTENTIAL OF HUMAN PERINATAL STEM CELLS 139Oleg V. Semenov and Christian BreymannRole of Stem Cells in Regenerative Medicine 139Perinatal Stem Cell Sources 140Properties of Perinatal Mesenchymal Stem Cells 143Properties of Perinatal Hematopoietic Stem Cells 144Biomedical Applications of Human Perinatal Stem Cells 145Perspectives and Obstacles 147References 14811 PROGENITOR CELL THERAPY FOR THE TREATMENT OF TRAUMATIC BRAIN INJURY 155Alex Bryan Olsen, Robert A. Hetz, Supinder S. Bedi, and Charles S. Cox, Jr.Introduction 155Cellular Therapy for the Treatment of TBI 159Neural Stem Progenitor Cells 159Human Multipotent Adult Progenitor Cells 160Mesenchymal Stem Cells 163Umbilical Cord Blood 165Wharton’s Jelly 166Amniotic Fluid-Derived Stem Cells 167The Inflammatory Reflex 168Conclusion 170References 17112 THE HUMAN AMNIOTIC MEMBRANE: A TISSUE WITH MULTIFACETED PROPERTIES AND DIFFERENT POTENTIAL CLINICAL APPLICATIONS 177Maddalena Caruso, Antonietta Silini, and Ornella ParoliniIntroduction 177Structure and Histology of the Human Amniotic Membrane 178Preparation, Preservation, and Sterilization of the Human Amniotic Membrane 179Biological and Structural Properties of the Human Amniotic Membrane Generally Invoked to Explain Its Effects in Vivo 180Established Clinical Applications of the Human Amniotic Membrane 183Prospective Applications of the Human Amniotic Membrane: Lessons from Preclinical Studies 187Conclusions and Perspectives 190References 19013 ADVANCES AND POSSIBLE APPLICATIONS OF HUMAN AMNION FOR THE MANAGEMENT OF LIVER DISEASE 197Fabio Marongiu, Maria Paola Serra, Marcella Sini, Ezio Laconi, Marc C. Hansel, Kristen J. Skvorak, Roberto Gramignoli, and Stephen C. StromIntroduction 197Human Amnion for the Management of Liver Fibrosis 198Amnion-Derived Hepatocytes and Their Possible Applications 199Conclusions 204References 20514 AMNION-DERIVED CELLS FOR STROKE RESTORATIVE THERAPY 209Naoki Tajiri, Loren E. Glover, and Cesar V. BorlonganIntroduction 209Stem Cell Therapy: Beyond Stroke Neuroprotection 210Therapeutic Potential of Adult Stem Cells 210The Biology of Amnion-Derived Cells 211Amnion-Derived Cells for Cell Therapy 212Conclusion 215References 21615 PREGNANCY-ACQUIRED FETAL PROGENITORS AS NATURAL CELL THERAPY 221Elke Seppanen, Nicholas M. Fisk,and Kiarash KhosrotehraniIntroduction 221Fetal Cell Microchimerism, a Widespread Phenomenon 222The Kinetics of Fetal Cell Detection 222Factors Modifying the Level of Microchimerism 222Detecting FMC 223Homing and Plasticity of FMC 224Hematopoietic Capacity of FMC 224Epithelial, Neuronal and Hepatic Capacity of FMC 228Mesenchymal Capacity of FMC 228FMC Includes Functional Endothelial Progenitor Cells that Contribute to Tissue Repair 229FMC Likely Includes Cells of Placental Origin 230Conclusions 230References 231INDUSTRY REVIEW 23516 PERINATAL STEM CELLS: AN INDUSTRY PERSPECTIVE 237Kyle J. CetruloIntroduction 237The Public Cord Blood Banking Industry 238The Private Banking Industry 239Research and Cord Blood Clinical Trials 240The Mesenchymal Stem Cell Regenerative Medicine Industry 241Wharton’s Jelly/Cord Tissue 242Placental Stem Cells and Placental Tissue 243Amniotic Fluid 244Conclusion 245References 24517 PATENT PROTECTION OF STEM CELL INNOVATIONS 249John R. WetherellThe Role of Patents in Commercialization 249Background of the Patent System 250Patentable Subject Matter 251Statutory Requirements for a Patent 252Written Description/Enablement/Best Mode 254Important Future Changes 25618 INTERVIEW WITH FRANCES VERTER, FOUNDER OF PARENT’S GUIDE TO CORD BLOOD FOUNDATION 259Frances Verter and Kyle J. CetruloReferences 26919 UMBILICAL CORD BLOOD BANKING: AN OBSTETRICIAN’S PERSPECTIVE 271Jordan H. PerlowReferences 277Index 279