Perinatal Stem Cells

Research and Therapy

Inbunden, Engelska, 2018

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Beskrivning

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton's jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury.

In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry.

Explores current clinical and pre-clinical application of stem cells derived from perinatal sources
Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment
Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells
Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Produktinformation

Utgivningsdatum:2018-06-21
Mått:216 x 276 x 23 mm
Vikt:1 560 g
Format:Inbunden
Språk:Engelska
Antal sidor:418
Förlag:Elsevier Science
ISBN:9780128120156

Utforska kategorier

Biomedicinsk teknik inom Medicin
Gynekologi och obstetrik inom Medicin

Mer om författaren

Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine. Seventeen of his lab’s technologies have been translated to patients, including the first tissue-engineered organ for permanent implantation in a human. His research led to the discovery of a multipotent source of stem cells from amniotic fluid and placenta, advances in 3D printing of tissues and organs, and body-on-a-chip technologies. His work was twice listed among Time Magazine’s top 10 medical breakthroughs of the year, and he is a recipient of the Smithsonian Ingenuity Award. He has published over 900 journal articles, is the editor of 25 books, and holds over 250 national and international patents. Dr. Atala is a member of the National Academy of Medicine, the National Academy of Inventors, and the American Institute for Medical and Biological Engineering.

Innehållsförteckning

Section I. Amniotic Fluid-Derived Stem Cells1. In utero therapy for congenital disorders using amniotic fluid stem cells2. The Amniotic Fluid Stem Cell Secretome: at the Heart of Regeneration3. Transplantation of Amniotic Fluid-Derived Neural Stem Cells4. Stroke therapy: the potential of amniotic fluid-derived stem cells 5. Vascular formation by human perinatal stem cells6. Amniotic Fluid Stem Cells for Kidney RegenerationSection II. Placental and Placental Membrane-Derived Stem Cells7. Placental mesenchymal stem cells for cellular cardiomyoplasty8. Heterogeneous functions of perinatal mesenchymal stromal cells require a preselection before their banking for clinical use 9. Defining the fetal stem cell niche in the human placenta10. Banking placental tissue hematopoietic stem cells and mesenchymal stem cells for clinical use11. Immuno-modulatory mechanisms of placental stem cells12. Amnion Membrane Allograft for Regenerative Medicine13. Perinatal cells and biomaterials for wound healing14. Placental Stem Cells15. Therapeutic Effect of Extracellular Vesicles Derived from Adult/Perinatal Human Mesenchymal Stem CellsSection III. Umbilical Cord-Derived Cells16. Ex-vivo Expansion of Cord Blood Stem Cells17. Cord Blood Transplantation: Therapeutic Use of Perinatal Stem Cells 18. Autologous Human Cord Blood as a Treatment for Traumatic Brain Injury in Children19. Phenotypic and Functional Characterization Perinatal Stem Cells Isolated from Umbilical Cord Tissue20. Mesenchymal stromal cells from Wharton’s jelly (WJ-MSCs): coupling their hidden differentiative program with their frank immunomodulatory phenotype21. Regeneration of ischemic cardiovascular damage using Jelly Wharton as an unlimited source of therapeutic stem cells22. Phenotype with Focused Paracrine Fractions: Effecting Future Phenotype with Focused Paracrine FractionsSection IV. Clinical and Industry Perspective23. Clinical Translation of Perinatal Stem Cell Therapy 24. Current Clinical Trials utilizing Perinatal Stem Cells – A Review 25. Review Of Processing Technology and Techniques for Perinatal Stem Cells Banking And Clinical Applications26. Clinical Development And Commercialization Of Placenta-Derived Cell Therapy 27. How the patent landscape has changed28. The Need for Better Assays to Predict the Effectiveness of Tissue Stem Cell Treatments