Hong Wang is a professor of pharmacology at Temple University School of Medicine. Her research focuses on mechanisms of vascular disease, using research approaches includinggenetic cloning, molecular biology, protein chemistry and immunohistochemistry. Dr. Wang is the author of numerous publications in peer reviewed journals including Cardiovascular Research, Atherosclerosis, Blood, and Trends in Cardiovascular Medicine.

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• Contributors ixForewordJoseph Loscalzo xvPrefaceEric N. Olson xviiSection I: Risk Factors: Old and New 11 Lipoproteins 3Ming-Lin Liu and Daniel J. Rader2 Role of Dysglycemia in Atherosclerosis 15David R. Clemmons3 Glycation, Inflammation and RAGE: Mechanisms Contributing to the Accelerated Atherosclerosis of Diabetes 27Ravichandran Ramasamy, Shi Fang Yan, and Ann Marie Schmidt4 Inflammation 43Caitlin Collins, Ellie Tzima, and Cam Patterson5 Homocysteine: A Controversial Cardiovascular Risk Factor 53Sanjana Dayal and Steven R. Lentz6 Hypertension as a Risk Factor for Atherosclerosis 63Annet Kirabo and David G. Harrison7 The Genetics of Atherosclerosis: From Polymorphisms to Populations 77Paul Johnson, Jack Kuritzky, and Marschall Runge8 Life Style 93Wayne E. CascioSection II: Cellular Mechanisms 1059 Endothelial Cells 107G. Brandon Atkins, Gabriela Orasanu, and Mukesh K. Jain10 Vascular Smooth Muscle Cells 117Dario F. Riascos-Bernal and Nicholas E. S. Sibinga11 Fibroblasts 129Christopher Mack12 Monocytes and Macrophages in Atherosclerosis 141Shu Meng, Pu Fang, Xiaofeng Yang, and Hong Wang13 Lymphocytes and Atherosclerosis 155Anthony Virtue, Jietang Mai, Hong Wang, and Xiaofeng Yang14 Stem Cells 173Arjun Deb15 Platelets 187Jerry Ware and Adam Corken16 Development and Use of Mouse Models of Atherosclerosis 197Peggy Robinet and Jonathan D. SmithSection III: Molecular Mechanisms 20717 Mechanisms of the Renin Angiotensin System Influencing Atherosclerosis 209Hong Lu and Alan Daugherty18 The Role of Caveolae and Caveolins in Atherogenesis 221Victor Rizzo19 Lysosomal Molecular Derangements in Atherosclerosis 235Pin-Lan Li and Yang Zhang20 C-Reactive Protein and Its Pathophysiological Roles in Atherosclerosis 247Jianglin Fan, Jifeng Zhang, and Yuqing Eugene Chen21 Paraoxonases 257Srinivasa T. Reddy22 Prostanoids, Their Receptors, and Atherogenesis 267Domenico Praticò23 Extracellular Phospholipases: Role in Inflammation and Atherosclerotic Cardiovascular Disease 279Uwe J.F. Tietge24 Apolipoprotein-B: The Crucial Protein of Atherogenic Lipoproteins 291Kevin Jon Williams and Edward A. Fisher25 HDL Receptor Scavenger Receptor BI: A Multipurpose Player in Cholesterol and Steroid Metabolism in Mice and Man 313Ying Zhao, Menno Hoekstra, Suzanne J. A. Korporaal, Theo J. C. Van Berkel, and Miranda Van Eck26 Pro and Anti-Inflammatory Cytokine Networks in Atherosclerosis 329Michael V. Autieri27 E CM and Atherosclerosis 343Jie Du, Ying Wang, and Lixin JiaSection IV: Biochemical Mechanisms 35328 Effects of Nitric Oxide on Atherosclerosis 355Terrence Pong and Paul L. Huang29 Protective Role of Heme Oxygenase-1 in Atherosclerosis 365William Durante30 Roles of Reactive Oxygen Species in Physiology and Pathology 379Ping Song and Ming-Hui Zou31 Hydrogen Sulfide: Role in Atherosclerosis, Mechanisms, and Therapeutic Potential 393Elvis A. Peter, Jai Varma, and Christopher G. Kevil32 Methylation and Atherosclerosis 405Xin-Yu Xiong, Shu Meng, Xiaofeng Yang, and Hong Wang33 Micromanaging Atherogenesis: Role of Micrornas in Atherosclerosis 423Shusheng Wang and Chastain Anderson34 Posttranslational Modifications: Role in Atherosclerosis 437Justyna Fert-Bober, Ronald J. Holewinski, Joel A. Kooren, and Jennifer E. Van Eyk35 Phosphorylation Regulation by Kinases and Phosphatases in Atherosclerosis 453Katherine J. Elliott and Satoru Eguchi36 Effect of MMPs on Cardiovasculature and Blood Flow: Role of Ros, Mitophagy, and Antioxidants 467Thomas P. Vacek, Diana Neamtu, and Suresh C. TyagiSection V: Clinical Management 47937 Impact of Preventive Therapies on Clinical Management and Outcomes 481Danny Eapen, Ahsan Achtchi, Reynaria Nieva, Kiran Valiani, Faresa Zarreen, Aalok Patel, Allen Dollar, Ijeoma Isiadinso, Susmita Parashar, Jefferson Baer, Kreton Mavromatis, and Laurence Sperling38 Risk Stratification in Clinical Practice 495Phil Mendys, Golsa Joodi, and Ross J. Simpson, Jr.39 Molecular Imaging 503Arun K. Thukkani and Farouc A. Jaffer40 Pharmacological Therapy in the Management of Acute Coronary Syndromes 517Andrew J. Sampson, Timir Paul, and George A. Stouffer41 Targeted Molecular Therapeutics for Atherosclerosis 533Lantz C. Mackey and Jonathon W. Homeister42 High-Density Lipoprotein Therapies—Then and Now 545Henry J. Pownall, Corina Rosales, Baiba K. Gillard, and Antonio M. Gotto, Jr.43 Stem Cell Therapeutics 557Mei Mei Wong and Qingbo Xu44 Advances in Surgical Revascularization 567Stephen J. Forest, Ahmed Khan, and Joseph J. DeRose, Jr.Index 579

Hong Wang is a professor of pharmacology at Temple University School of Medicine. Her research focuses on mechanisms of vascular disease, using research approaches includinggenetic cloning, molecular biology, protein chemistry and immunohistochemistry. Dr. Wang is the author of numerous publications in peer reviewed journals including Cardiovascular Research, Atherosclerosis, Blood, and Trends in Cardiovascular Medicine.

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• Contributors ixForewordJoseph Loscalzo xvPrefaceEric N. Olson xviiSection I: Risk Factors: Old and New 11 Lipoproteins 3Ming-Lin Liu and Daniel J. Rader2 Role of Dysglycemia in Atherosclerosis 15David R. Clemmons3 Glycation, Inflammation and RAGE: Mechanisms Contributing to the Accelerated Atherosclerosis of Diabetes 27Ravichandran Ramasamy, Shi Fang Yan, and Ann Marie Schmidt4 Inflammation 43Caitlin Collins, Ellie Tzima, and Cam Patterson5 Homocysteine: A Controversial Cardiovascular Risk Factor 53Sanjana Dayal and Steven R. Lentz6 Hypertension as a Risk Factor for Atherosclerosis 63Annet Kirabo and David G. Harrison7 The Genetics of Atherosclerosis: From Polymorphisms to Populations 77Paul Johnson, Jack Kuritzky, and Marschall Runge8 Life Style 93Wayne E. CascioSection II: Cellular Mechanisms 1059 Endothelial Cells 107G. Brandon Atkins, Gabriela Orasanu, and Mukesh K. Jain10 Vascular Smooth Muscle Cells 117Dario F. Riascos-Bernal and Nicholas E. S. Sibinga11 Fibroblasts 129Christopher Mack12 Monocytes and Macrophages in Atherosclerosis 141Shu Meng, Pu Fang, Xiaofeng Yang, and Hong Wang13 Lymphocytes and Atherosclerosis 155Anthony Virtue, Jietang Mai, Hong Wang, and Xiaofeng Yang14 Stem Cells 173Arjun Deb15 Platelets 187Jerry Ware and Adam Corken16 Development and Use of Mouse Models of Atherosclerosis 197Peggy Robinet and Jonathan D. SmithSection III: Molecular Mechanisms 20717 Mechanisms of the Renin Angiotensin System Influencing Atherosclerosis 209Hong Lu and Alan Daugherty18 The Role of Caveolae and Caveolins in Atherogenesis 221Victor Rizzo19 Lysosomal Molecular Derangements in Atherosclerosis 235Pin-Lan Li and Yang Zhang20 C-Reactive Protein and Its Pathophysiological Roles in Atherosclerosis 247Jianglin Fan, Jifeng Zhang, and Yuqing Eugene Chen21 Paraoxonases 257Srinivasa T. Reddy22 Prostanoids, Their Receptors, and Atherogenesis 267Domenico Praticò23 Extracellular Phospholipases: Role in Inflammation and Atherosclerotic Cardiovascular Disease 279Uwe J.F. Tietge24 Apolipoprotein-B: The Crucial Protein of Atherogenic Lipoproteins 291Kevin Jon Williams and Edward A. Fisher25 HDL Receptor Scavenger Receptor BI: A Multipurpose Player in Cholesterol and Steroid Metabolism in Mice and Man 313Ying Zhao, Menno Hoekstra, Suzanne J. A. Korporaal, Theo J. C. Van Berkel, and Miranda Van Eck26 Pro and Anti-Inflammatory Cytokine Networks in Atherosclerosis 329Michael V. Autieri27 E CM and Atherosclerosis 343Jie Du, Ying Wang, and Lixin JiaSection IV: Biochemical Mechanisms 35328 Effects of Nitric Oxide on Atherosclerosis 355Terrence Pong and Paul L. Huang29 Protective Role of Heme Oxygenase-1 in Atherosclerosis 365William Durante30 Roles of Reactive Oxygen Species in Physiology and Pathology 379Ping Song and Ming-Hui Zou31 Hydrogen Sulfide: Role in Atherosclerosis, Mechanisms, and Therapeutic Potential 393Elvis A. Peter, Jai Varma, and Christopher G. Kevil32 Methylation and Atherosclerosis 405Xin-Yu Xiong, Shu Meng, Xiaofeng Yang, and Hong Wang33 Micromanaging Atherogenesis: Role of Micrornas in Atherosclerosis 423Shusheng Wang and Chastain Anderson34 Posttranslational Modifications: Role in Atherosclerosis 437Justyna Fert-Bober, Ronald J. Holewinski, Joel A. Kooren, and Jennifer E. Van Eyk35 Phosphorylation Regulation by Kinases and Phosphatases in Atherosclerosis 453Katherine J. Elliott and Satoru Eguchi36 Effect of MMPs on Cardiovasculature and Blood Flow: Role of Ros, Mitophagy, and Antioxidants 467Thomas P. Vacek, Diana Neamtu, and Suresh C. TyagiSection V: Clinical Management 47937 Impact of Preventive Therapies on Clinical Management and Outcomes 481Danny Eapen, Ahsan Achtchi, Reynaria Nieva, Kiran Valiani, Faresa Zarreen, Aalok Patel, Allen Dollar, Ijeoma Isiadinso, Susmita Parashar, Jefferson Baer, Kreton Mavromatis, and Laurence Sperling38 Risk Stratification in Clinical Practice 495Phil Mendys, Golsa Joodi, and Ross J. Simpson, Jr.39 Molecular Imaging 503Arun K. Thukkani and Farouc A. Jaffer40 Pharmacological Therapy in the Management of Acute Coronary Syndromes 517Andrew J. Sampson, Timir Paul, and George A. Stouffer41 Targeted Molecular Therapeutics for Atherosclerosis 533Lantz C. Mackey and Jonathon W. Homeister42 High-Density Lipoprotein Therapies—Then and Now 545Henry J. Pownall, Corina Rosales, Baiba K. Gillard, and Antonio M. Gotto, Jr.43 Stem Cell Therapeutics 557Mei Mei Wong and Qingbo Xu44 Advances in Surgical Revascularization 567Stephen J. Forest, Ahmed Khan, and Joseph J. DeRose, Jr.Index 579

Hong Wang is a professor of pharmacology at Temple University School of Medicine. Her research focuses on mechanisms of vascular disease, using research approaches includinggenetic cloning, molecular biology, protein chemistry and immunohistochemistry. Dr. Wang is the author of numerous publications in peer reviewed journals including Cardiovascular Research, Atherosclerosis, Blood, and Trends in Cardiovascular Medicine.

Select Guide Rating

• Contributors ixForewordJoseph Loscalzo xvPrefaceEric N. Olson xviiSection I: Risk Factors: Old and New 11 Lipoproteins 3Ming-Lin Liu and Daniel J. Rader2 Role of Dysglycemia in Atherosclerosis 15David R. Clemmons3 Glycation, Inflammation and RAGE: Mechanisms Contributing to the Accelerated Atherosclerosis of Diabetes 27Ravichandran Ramasamy, Shi Fang Yan, and Ann Marie Schmidt4 Inflammation 43Caitlin Collins, Ellie Tzima, and Cam Patterson5 Homocysteine: A Controversial Cardiovascular Risk Factor 53Sanjana Dayal and Steven R. Lentz6 Hypertension as a Risk Factor for Atherosclerosis 63Annet Kirabo and David G. Harrison7 The Genetics of Atherosclerosis: From Polymorphisms to Populations 77Paul Johnson, Jack Kuritzky, and Marschall Runge8 Life Style 93Wayne E. CascioSection II: Cellular Mechanisms 1059 Endothelial Cells 107G. Brandon Atkins, Gabriela Orasanu, and Mukesh K. Jain10 Vascular Smooth Muscle Cells 117Dario F. Riascos-Bernal and Nicholas E. S. Sibinga11 Fibroblasts 129Christopher Mack12 Monocytes and Macrophages in Atherosclerosis 141Shu Meng, Pu Fang, Xiaofeng Yang, and Hong Wang13 Lymphocytes and Atherosclerosis 155Anthony Virtue, Jietang Mai, Hong Wang, and Xiaofeng Yang14 Stem Cells 173Arjun Deb15 Platelets 187Jerry Ware and Adam Corken16 Development and Use of Mouse Models of Atherosclerosis 197Peggy Robinet and Jonathan D. SmithSection III: Molecular Mechanisms 20717 Mechanisms of the Renin Angiotensin System Influencing Atherosclerosis 209Hong Lu and Alan Daugherty18 The Role of Caveolae and Caveolins in Atherogenesis 221Victor Rizzo19 Lysosomal Molecular Derangements in Atherosclerosis 235Pin-Lan Li and Yang Zhang20 C-Reactive Protein and Its Pathophysiological Roles in Atherosclerosis 247Jianglin Fan, Jifeng Zhang, and Yuqing Eugene Chen21 Paraoxonases 257Srinivasa T. Reddy22 Prostanoids, Their Receptors, and Atherogenesis 267Domenico Praticò23 Extracellular Phospholipases: Role in Inflammation and Atherosclerotic Cardiovascular Disease 279Uwe J.F. Tietge24 Apolipoprotein-B: The Crucial Protein of Atherogenic Lipoproteins 291Kevin Jon Williams and Edward A. Fisher25 HDL Receptor Scavenger Receptor BI: A Multipurpose Player in Cholesterol and Steroid Metabolism in Mice and Man 313Ying Zhao, Menno Hoekstra, Suzanne J. A. Korporaal, Theo J. C. Van Berkel, and Miranda Van Eck26 Pro and Anti-Inflammatory Cytokine Networks in Atherosclerosis 329Michael V. Autieri27 E CM and Atherosclerosis 343Jie Du, Ying Wang, and Lixin JiaSection IV: Biochemical Mechanisms 35328 Effects of Nitric Oxide on Atherosclerosis 355Terrence Pong and Paul L. Huang29 Protective Role of Heme Oxygenase-1 in Atherosclerosis 365William Durante30 Roles of Reactive Oxygen Species in Physiology and Pathology 379Ping Song and Ming-Hui Zou31 Hydrogen Sulfide: Role in Atherosclerosis, Mechanisms, and Therapeutic Potential 393Elvis A. Peter, Jai Varma, and Christopher G. Kevil32 Methylation and Atherosclerosis 405Xin-Yu Xiong, Shu Meng, Xiaofeng Yang, and Hong Wang33 Micromanaging Atherogenesis: Role of Micrornas in Atherosclerosis 423Shusheng Wang and Chastain Anderson34 Posttranslational Modifications: Role in Atherosclerosis 437Justyna Fert-Bober, Ronald J. Holewinski, Joel A. Kooren, and Jennifer E. Van Eyk35 Phosphorylation Regulation by Kinases and Phosphatases in Atherosclerosis 453Katherine J. Elliott and Satoru Eguchi36 Effect of MMPs on Cardiovasculature and Blood Flow: Role of Ros, Mitophagy, and Antioxidants 467Thomas P. Vacek, Diana Neamtu, and Suresh C. TyagiSection V: Clinical Management 47937 Impact of Preventive Therapies on Clinical Management and Outcomes 481Danny Eapen, Ahsan Achtchi, Reynaria Nieva, Kiran Valiani, Faresa Zarreen, Aalok Patel, Allen Dollar, Ijeoma Isiadinso, Susmita Parashar, Jefferson Baer, Kreton Mavromatis, and Laurence Sperling38 Risk Stratification in Clinical Practice 495Phil Mendys, Golsa Joodi, and Ross J. Simpson, Jr.39 Molecular Imaging 503Arun K. Thukkani and Farouc A. Jaffer40 Pharmacological Therapy in the Management of Acute Coronary Syndromes 517Andrew J. Sampson, Timir Paul, and George A. Stouffer41 Targeted Molecular Therapeutics for Atherosclerosis 533Lantz C. Mackey and Jonathon W. Homeister42 High-Density Lipoprotein Therapies—Then and Now 545Henry J. Pownall, Corina Rosales, Baiba K. Gillard, and Antonio M. Gotto, Jr.43 Stem Cell Therapeutics 557Mei Mei Wong and Qingbo Xu44 Advances in Surgical Revascularization 567Stephen J. Forest, Ahmed Khan, and Joseph J. DeRose, Jr.Index 579