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      Cannabinoids

      AvVincenzo Di Marzo

      Inbunden, Engelska, 2014

      Del i serien Neuroscience Intelligence Unit

      1 519 kr

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      Inbunden

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      1 767 kr

      Beskrivning

      Cannabinoids ‘Cannabinoids’ is a broad term covering a group of natural products from Cannabis sativa, one of which locks on to specific receptors – protein molecules on the surface of cells – known as cannabinoid receptors. Over the past decades scientists have found that cannabinoid receptors and their endogenous ligands, the endocannabinoids, are involved in a vast array of physiological functions, including helping to control brain activity, energy metabolism, heart function, the immune system and even reproduction. In Cannabinoids, Vincenzo Di Marzo has assembled contributions from international experts to provide the definitive guide to what continues to be a rapidly developing research field. After an introductory historical chapter, the book continues by looking at the biochemical, genetic and molecular elements of cannabinoids, followed by chapters covering their role in health and disease. The final chapter outlines the need for a new nomenclature to reflect the complex and multi-disciplinary nature of this area. An authoritative guide to the history, development and possible future of cannabinoid research. Includes contributions from leading international experts in the field. Clearly written, well organised and logically presented. Cannabinoids will prove invaluable to researchers, practitioners and students across a wide range of disciplines, needing an up-to-date guide to this significant area of research.

      Produktinformation

      • Utgivningsdatum:2014-08-08
      • Mått:175 x 252 x 21 mm
      • Vikt:640 g
      • Format:Inbunden
      • Språk:Engelska
      • Serie:Neuroscience Intelligence Unit
      • Antal sidor:320
      • Förlag:John Wiley and Sons Ltd
      • ISBN:9781118451298

      Utforska kategorier

      • Tillverkningsteknik inom Naturvetenskap och teknik

      Mer om författaren

      Vicenzo Di MarzoEndocannabinoid Research Group, Pozzuoli, Italy

      Innehållsförteckning

      • List of Contributors xiiiPreface xv1 Looking ahead after 50 years of research on cannabinoids 1Raphael Mechoulam1.1 Summary 11.2 Introduction 11.3 Cannabidiol (CBD) 61.4 Fatty acid amides of amino acids and related compounds 81.5 Conclusions 101.6 References 102 Cannabinoid receptor intracellular signalling: The long journey from binding sites to biological effects 17Lawrence C. Blume, Khalil M. Eldeeb and Allyn C. Howlett2.1 Historical progression: Serendipity to opportunity 182.2 Significance of being a G protein coupled receptor (GPCR) 212.3 CB1 cannabinoid receptor interactions with other cellular signals 232.4 Functional role of CB1 receptor accessory proteins 252.5 Opportunities: Pharmacotherapeutic insights based on cell signalling 332.6 Concluding remarks 412.7 References 413 Endocannabinoid biochemistry: What do we know after 50 years? 53Filomena Fezza and Mauro Maccarrone3.1 Introduction 543.2 Endocannabinoids and related molecules 603.3 Biosynthesis of endocannabinoids and related molecules 663.4 Degradation of endocannabinoids 713.5 Oxidative metabolism of endocannabinoids 773.6 Conclusions and future perspectives 783.7 References 834 Genetic dissection of the endocannabinoid system and how it changed our knowledge of cannabinoid pharmacology and mammalian physiology 95Beat Lutz4.1 Introduction: To set the stage 964.2 Tool box for genetic dissection 974.3 Understanding cannabinoid pharmacology 1064.4 Unravelling endocannabinoid system functions 1134.5 Caveats in genetics 1244.6 What have we learnt about cannabinoid pharmacology and mammalian physiology? 1254.7 Perspectives 1274.8 References 1275 Cannabinoids, endocannabinoids and stress 139Cecilia J. Hillard, Qing-song Liu, XiaoQian Liu, Bin Pan, Christopher J. Roberts and Leyu Shi5.1 Introduction 1405.2 Regulation of endocannabinoid signalling by stress 1435.3 ECS regulation of the HPA axis response to stress 1545.4 ECS role in SNS responses to stress 1595.5 Stress and ECS in the periphery 1615.6 Summary 1625.7 References 1636 Cannabinoids and the brain: New hopes for new therapies 175Javier Fernández-Ruiz, Mariluz Hernández and Yolanda García-Movellán6.1 Cannabinoids and the brain: A long journey together 1766.2 Brain processes and brain disorders investigated in relation to the endocannabinoid system 1806.3 Concluding remarks and future perspectives 2026.4 References 2027 Potential therapeutic applications of cannabinoids in gastrointestinal and liver diseases: Focus on Δ9 -tetrahydrocannabinol pharmacology 219Paolo Caraceni, Francesca Borrelli, Ferdinando A. Giannone and Angelo A. Izzo7.1 Introduction 2207.2 The endocannabinoid system in the gut and in the liver 2207.3 Potential therapeutic applications of cannabinoids in the gastrointestinal tract 2217.4 Potential therapeutic applications of cannabinoids in the liver 2347.5 Conclusions 2457.6 References 2468 Fifty years of ‘cannabinoid research’ and the need for a new nomenclature 261Vincenzo Di Marzo and Luciano De Petrocellis8.1 An introduction to cannabinoid research and the ‘old’ nomenclature in this field (before the year 2000) 2628.2 ‘New’ nomenclature (after the year 2000) 2698.3 ‘Multi-target’ compounds 2808.4 Conclusions 2818.5 References 281Index 291
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