Targeted Therapy in Translational Cancer Research

Apostolia-Maria Tsimberidou, MD PhDDepartment of Investigational Cancer TherapeuticsThe University of Texas MD Anderson Cancer CenterHouston, TX, USARazelle KurzrockCenter for Personalized Cancer Therapy, UC San Diego - Moores Cancer CenterLa Jolla, CA, USAKenneth C. Anderson MDLeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical SchoolBoston, MA, USA

• List of Contributors, viiSeries Foreword, xiiiForeword, xvPreface, xviiPart I Principles of Targeted Therapies1 Toward Personalized Therapy for Cancer, 3Ashley M. Holder and FundaMeric-Bernstam2 Combining Targeted Therapies, 14Jordi Rodon, Analia Azaro, Davis Torrejon, and Razelle Kurzrock3 Principles of Targeted Immunotherapy, 27Susanne H. C. Baumeister and Glenn Dranoff4 Cancer Stem Cell Principles, 39Allison C. Sharrow, Gabriel Ghiaur, and Richard J. Jones5 The Tumor Microenvironment as a Target for Therapeutic Intervention, 47Hua Fang and Yves A. DeClerck6 The Role of Angiogenesis in Cancer, 64Morgan Taylor, Robert L. Coleman, and Anil K. Sood7 Epigenetics and Epigenetic Therapy of Cancer, 72Omotayo Fasan, Patrick Boland, PatriciaKropf, and Jean-Pierre J. Issa8 The Role of microRNAs in Cancer, 80Gianpiero Di Leva and Carlo M. Croce9 AcuteMyeloidLeukemia, 89Ofir Wolach and Richard M. Stone10 Targeted and Functional Imaging, 101Jian Q. (Michael) Yu, Drew A. Torigian, and Abass AlaviPart II Targeted Therapy in Hematological Malignancies11 Targeted Therapies in Chronic Myeloid Leukemia, 113Elias Jabbour and Jorge Cortes12 Targeted Therapy for Acute Lymphoblastic Leukemia, 121Nitin Jain, Susan O’Brien, and Farhad Ravandi-Kashani13 Chronic Lymphocytic Leukemia, 130Preetesh Jain and Susan O’Brien14 Multiple Myeloma, 145Giada Bianchi and Kenneth C. Anderson15 The Impact of Genomics on Targeted Therapy in Multiple Myeloma and Lymphomas, 157Jens G. Lohr and Birgit Knoechel16 Targeted Therapy in Myelodysplastic Syndromes, 162Guillermo Montalb´an-Bravo and Guillermo Garc´ýa-Manero17 Lymphoma and Targeted Therapies, 169Sonali M. Smith and Julie M. VosePart III Targeted Therapy in Solid Tumors18 Targeted Therapy in Solid Tumors: Brain, 179Shiao-PeiWeathers, Barbara J. O’Brien, John F. de Groot, andW. K. Alfred Yung19 Targeted Therapy for Breast Cancer, 190Harold J. Burstein20 Targeted Therapy in Solid Tumors: Colorectal Cancer, 193Maen Abdelrahim, Scott Kopetz, and David Menter21 Endometrial Cancer, 205Jessica L. Bowser, Russell R. Broaddus, Robert L. Coleman, and Shannon N. Westin22 Targeted Therapy in Solid Tumors: Head and Neck, 216Marcus M. Monroe and Jeffrey N. Myers23 Targeted Therapy in Solid Tumors: Lung Cancer, 224Saiama N.Waqar, Daniel Morgensztern, and Roy S. Herbst24 Targeted Therapy in Melanoma, 231Keith T. Flaherty25 Ovarian Cancer, 240Shannon N.Westin, Larissa A. Meyer, and Robert L. Coleman26 Molecular Therapeutics: Pancreatic Cancer, 255David Fogelman, Milind Javle, and James Abbruzzese27 Targeted Therapies for Pediatric Solid Tumors, 263Jasmine Quynh Dao and Patrick A. Zweidler-McKay28 Prostate Cancer, 273William G. Nelson, Michael C. Haffner, and Srinivasan Yegnasubramanian29 Renal Cell Carcinoma and Targeted Therapy, 287Benjamin A. Gartrell, Alexander C. Small, William K. Oh, and Matthew D. Galsky30 Targeted Therapy in Solid Tumors: Sarcomas, 296Anthony P. Conley, Vinod Ravi, and Shreyaskumar PatelPart IV Targeted Therapy for Specific Molecular Aberrations31 RAS-RAF-MEK Pathway: Aberrations and Therapeutic Possibilities, 305Javier Munoz and Filip Janku32 The Phosphatidylinositol 3-Kinase Pathway in Human Malignancies, 315Samuel J. Klempner,Thanh-Trang Vo, Andrea P. Myers, and Lewis C. Cantley33 Current Status and Future Direction of PARP Inhibition in Cancer Therapy, 325Saeed Rafii, Stan Kaye and Susana Banerjee34 Targeting the c-Met Kinase, 341Chad Tang, M. Angelica Cortez, David Hong, and James W. Welsh35 KIT Kinase, 347Scott E. Woodman36 TP53, 353Kensuke Kojima and Michael AndreeffPart V Future Perspectives37 Future Perspectives, 363Rabih Said and Apostolia-Maria TsimberidouIndex, 371