Chemistry of Metalloproteins

Problems and Solutions in Bioinorganic Chemistry

AvJoseph J. Stephanos,Anthony W. Addison

Häftad, Engelska, 2014

Del i serien Wiley Series in Protein and Peptide Science

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Beskrivning

Addresses the full gamut of questions in metalloprotein scienceFormatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry.Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cationsMetalloenzymesCopper proteinsIron proteinsVitamin B12ChlorophyllChapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics.Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine.Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Produktinformation

Utgivningsdatum:2014-09-16
Mått:158 x 236 x 25 mm
Vikt:653 g
Format:Häftad
Språk:Engelska
Serie:Wiley Series in Protein and Peptide Science
Antal sidor:448
Förlag:John Wiley & Sons Inc
ISBN:9781118470442

Utforska kategorier

Biokemi inom Naturvetenskap och teknik

Mer om författaren

JOSEPH J. STEPHANOS, PHD, is Associate Professor of Bioinorganic, Biophysical, and Inorganic Chemistry at Menofia University. His research examines metalloprotein chemistry, ligand-binding, and coordination chemistry of biologically active compounds.ANTHONY W. ADDISON, PHD, is Professor of Inorganic Chemistry at Drexel University. His research focuses on bioinorganic chemistry; chemistry of dioxygen- and NO-binding metalloproteins; and the design, synthesis, and properties of novel chelating agents and macrocyclic and oligonuclear metal complexes. His numerous research articles and conference presentations have earned over 8,000 citations and a Hirsch Index of 37.

Innehållsförteckning

Preface ix1 Introduction 1Proteins: Formation, Structures, and Metalloproteins, 4References, 282 Alkali and Alkaline Earth Cations 31References, 673 Nonredox Metalloenzymes 71Carboxypeptidases, 75Carbonic Anhydrase, 84Alcohol Dehydrogenase, 88References, 914 Copper Proteins 95Introduction, 95Electronic Spectra of Copper Ions, 96ESR Spectra of Copper Ions, 105Copper Proteins, 117Plastocyanin, 119Azurin and Stellacyanin, 127Superoxide Dismutase, 131Hemocyanin, 135Ascorbic Oxidase, 139References, 1425 Iron Proteins 147Introduction, 147Electronic Spectra of Iron Ions, 148Mössbauer Spectroscopy of Iron Ions, 155ESR Spectra of Iron (III), 161Iron Bioavailability, 166Siderophores, 171Iron Storage and Transfer Proteins, 184Ferritin, 184Transferrin, 187Dioxygenase Iron Proteins, 195Iron–Sulfur Proteins, 207Rubredoxin, 207Ferredoxins, 2122Fe–2S Ferredoxins, 2124Fe–4S Ferredoxins, 221Aconitase, 226Hydroxylases, 229Hydrogenases, 232Nitrogenases, 240Binuclear Iron Proteins, 251Hemerythrin, 253Ribotide Reductase, Purple Acid Phosphate, and Methane Monooxygenase, 260Hemoproteins: Classification and Behavior of Heme in Absence of Globins, 267Myoglobin and Hemoglobin, 275Myoglobin, 275Hemoglobin, 280Cytochrome C, 298Electron Transfer in Porphyrins and Metalloporphyrins, 301Catalases, 311Peroxidases, 315Cytochrome P-450, 322Electronic Spectra of Hemoproteins, 327ESR Spectra of Hemoproteins, 362References, 3786 Vitamin B12 393References, 4057 Chlorophyll 407References, 421Index 423