Edited byBruce E. Sands MD, MS, AGAF, FACG, FACP, Chief of the Dr. Henry D. Janowitz Division of Gastroenterology,Mount Sinai Medical Center and Mount Sinai Health System, Dr. Burrill B. Crohn Professor of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USAScott L. Friedman MD, Fishberg Professor of Medicine, Dean for Therapeutic Discovery, Chief, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA

• List of Contributors, ixSeries Foreword, xivPreface, xvAbbreviation List, xviAbout the Companion Website, xxiPart 1: Approach to Specific Complaints1 Approach to Dysphagia, 3Gina R. Sam2 Approach to Nausea and Vomiting, 13Aimee L. Lucas3 Approach to Abdominal Pain, 21Jonathan Z. Potack4 Approach to Diarrhea, 31Bruce E. Sands5 Approach to Constipation, 45Mark A. Korsten, Hanumantha R. Ancha, and Miriam Kaminski6 Approach to Fecal Incontinence, 56Sita S. Chokhavatia7 Approach to Gastrointestinal Bleeding, 68Blair S. Lewis and Christina A. Tennyson8 Approach to Nutrition Assessment, 78Laura Manning and Lauren K. Schwartz9 Approach to the Pregnant Patient with GI Disorders, 87Elana A. MaserPart 2: Specific Diseases/Conditions10 Gastroesophageal Reflux Disease, 101Lawrence B. Cohen11 Barrett’s Esophagus, 111Sharmila Anandasabapathy12 Eosinophilic Esophagitis, 120Brijen J. Shah13 Esophageal Motility Disorders, 131Barry W. Jaffin14 Esophageal Disorders Related to Medication, Trauma, and Infection, 143Stuart I. Finkel15 Management of Foreign Bodies of the GI Tract, 156James George16 Functional Dyspepsia, 160Sita S. Chokhavatia17 Peptic Ulcer Disease, 170Neville D. Bamji and Ariel A. Benson18 Helicobacter pylori Treatment and Eradication, 180Anthony A. Weiss19 Gastroparesis, 193Eric S. Goldstein20 GI Complications of Obesity Surgery, 203Jonathan Z. Potack21 Tumors of the Foregut, 213Michelle Kang Kim22 Short Bowel Syndrome and Malnutrition, 222Lauren K. Schwartz and Benjamin L. Cohen23 Bacterial Overgrowth, 233Peter H. Rubin24 Celiac Disease, 238Ariel A. Benson and James Aisenberg25 Infectious Enteritis and Colitis; Bacterial Food Poisoning; Intestinal Protozoa and Helminthic Infestations, 250Jenny Sauk26 Immunodefi ciency and the GI Tract, 260Saurabh Mehandru27 GI Stromal Tumors, 270Peter E. Legnani28 Neuroendocrine Tumors, 279Richard R.P. Warner29 Pancreatitis (Acute, Chronic, Autoimmune), 292Jeffrey R. Lewis and Yuki Young30 Pancreatic Cysts and Tumors, 304Christopher J. DiMaio31 Disorders of the Biliary Tract, 323Ron Palmon and Kalpesh K. Patel32 GI Complications of Transplant, 336Vera Kandror Denmark33 Vascular Lesions of the GI Tract, 347Jose Romeu34 Irritable Bowel Syndrome, 358Charles D. Gerson35 Crohn’s Disease, 366Joana Torres and Jean-Frédéric Colombel36 Ulcerative Colitis, 379Adam F. Steinlauf and Daniel H. Present37 Complications of Restorative Proctocolectomy with Ileal Pouch-Anal Anastomosis, 390Joel J. Bauer and Stephen R. Gorfine38 Radiation Enterocolitis, 398Prashant Kedia and Adam Steinlauf39 Clostridium difficile, 411Gerald Friedman40 Ischemic Disease of the Small and Large Bowel, 422Ari Grinspan and Asher Kornbluth41 Diverticular Diseases of the Colon, 435David B. Sachar42 Adenocarcinoma of the Large Bowel and Hereditary Colon Cancer Syndromes, 443Steven H. Itzkowitz43 Colonoscopic Polypectomy, 455Jerome D. Waye44 Surveillance for Dysplasia in Inflammatory Bowel Disease, 467Thomas A. Ullman45 Diseases of the Anus and Rectum, 477Alexander J. Greenstein and Sergey Khaitov46 Complications of GI Endoscopy, 487James F. MarionIndex, 499A color plate section appears between pages 74 and 75

Edited byBruce E. Sands MD, MS, AGAF, FACG, FACP, Chief of the Dr. Henry D. Janowitz Division of Gastroenterology,Mount Sinai Medical Center and Mount Sinai Health System, Dr. Burrill B. Crohn Professor of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USAScott L. Friedman MD, Fishberg Professor of Medicine, Dean for Therapeutic Discovery, Chief, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA

• List of Contributors, ixSeries Foreword, xivPreface, xvAbbreviation List, xviAbout the Companion Website, xxiPart 1: Approach to Specific Complaints1 Approach to Dysphagia, 3Gina R. Sam2 Approach to Nausea and Vomiting, 13Aimee L. Lucas3 Approach to Abdominal Pain, 21Jonathan Z. Potack4 Approach to Diarrhea, 31Bruce E. Sands5 Approach to Constipation, 45Mark A. Korsten, Hanumantha R. Ancha, and Miriam Kaminski6 Approach to Fecal Incontinence, 56Sita S. Chokhavatia7 Approach to Gastrointestinal Bleeding, 68Blair S. Lewis and Christina A. Tennyson8 Approach to Nutrition Assessment, 78Laura Manning and Lauren K. Schwartz9 Approach to the Pregnant Patient with GI Disorders, 87Elana A. MaserPart 2: Specific Diseases/Conditions10 Gastroesophageal Reflux Disease, 101Lawrence B. Cohen11 Barrett’s Esophagus, 111Sharmila Anandasabapathy12 Eosinophilic Esophagitis, 120Brijen J. Shah13 Esophageal Motility Disorders, 131Barry W. Jaffin14 Esophageal Disorders Related to Medication, Trauma, and Infection, 143Stuart I. Finkel15 Management of Foreign Bodies of the GI Tract, 156James George16 Functional Dyspepsia, 160Sita S. Chokhavatia17 Peptic Ulcer Disease, 170Neville D. Bamji and Ariel A. Benson18 Helicobacter pylori Treatment and Eradication, 180Anthony A. Weiss19 Gastroparesis, 193Eric S. Goldstein20 GI Complications of Obesity Surgery, 203Jonathan Z. Potack21 Tumors of the Foregut, 213Michelle Kang Kim22 Short Bowel Syndrome and Malnutrition, 222Lauren K. Schwartz and Benjamin L. Cohen23 Bacterial Overgrowth, 233Peter H. Rubin24 Celiac Disease, 238Ariel A. Benson and James Aisenberg25 Infectious Enteritis and Colitis; Bacterial Food Poisoning; Intestinal Protozoa and Helminthic Infestations, 250Jenny Sauk26 Immunodefi ciency and the GI Tract, 260Saurabh Mehandru27 GI Stromal Tumors, 270Peter E. Legnani28 Neuroendocrine Tumors, 279Richard R.P. Warner29 Pancreatitis (Acute, Chronic, Autoimmune), 292Jeffrey R. Lewis and Yuki Young30 Pancreatic Cysts and Tumors, 304Christopher J. DiMaio31 Disorders of the Biliary Tract, 323Ron Palmon and Kalpesh K. Patel32 GI Complications of Transplant, 336Vera Kandror Denmark33 Vascular Lesions of the GI Tract, 347Jose Romeu34 Irritable Bowel Syndrome, 358Charles D. Gerson35 Crohn’s Disease, 366Joana Torres and Jean-Frédéric Colombel36 Ulcerative Colitis, 379Adam F. Steinlauf and Daniel H. Present37 Complications of Restorative Proctocolectomy with Ileal Pouch-Anal Anastomosis, 390Joel J. Bauer and Stephen R. Gorfine38 Radiation Enterocolitis, 398Prashant Kedia and Adam Steinlauf39 Clostridium difficile, 411Gerald Friedman40 Ischemic Disease of the Small and Large Bowel, 422Ari Grinspan and Asher Kornbluth41 Diverticular Diseases of the Colon, 435David B. Sachar42 Adenocarcinoma of the Large Bowel and Hereditary Colon Cancer Syndromes, 443Steven H. Itzkowitz43 Colonoscopic Polypectomy, 455Jerome D. Waye44 Surveillance for Dysplasia in Inflammatory Bowel Disease, 467Thomas A. Ullman45 Diseases of the Anus and Rectum, 477Alexander J. Greenstein and Sergey Khaitov46 Complications of GI Endoscopy, 487James F. MarionIndex, 499A color plate section appears between pages 74 and 75

Edited byBruce E. Sands MD, MS, AGAF, FACG, FACP, Chief of the Dr. Henry D. Janowitz Division of Gastroenterology,Mount Sinai Medical Center and Mount Sinai Health System, Dr. Burrill B. Crohn Professor of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USAScott L. Friedman MD, Fishberg Professor of Medicine, Dean for Therapeutic Discovery, Chief, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA

• List of Contributors, ixSeries Foreword, xivPreface, xvAbbreviation List, xviAbout the Companion Website, xxiPart 1: Approach to Specific Complaints1 Approach to Dysphagia, 3Gina R. Sam2 Approach to Nausea and Vomiting, 13Aimee L. Lucas3 Approach to Abdominal Pain, 21Jonathan Z. Potack4 Approach to Diarrhea, 31Bruce E. Sands5 Approach to Constipation, 45Mark A. Korsten, Hanumantha R. Ancha, and Miriam Kaminski6 Approach to Fecal Incontinence, 56Sita S. Chokhavatia7 Approach to Gastrointestinal Bleeding, 68Blair S. Lewis and Christina A. Tennyson8 Approach to Nutrition Assessment, 78Laura Manning and Lauren K. Schwartz9 Approach to the Pregnant Patient with GI Disorders, 87Elana A. MaserPart 2: Specific Diseases/Conditions10 Gastroesophageal Reflux Disease, 101Lawrence B. Cohen11 Barrett’s Esophagus, 111Sharmila Anandasabapathy12 Eosinophilic Esophagitis, 120Brijen J. Shah13 Esophageal Motility Disorders, 131Barry W. Jaffin14 Esophageal Disorders Related to Medication, Trauma, and Infection, 143Stuart I. Finkel15 Management of Foreign Bodies of the GI Tract, 156James George16 Functional Dyspepsia, 160Sita S. Chokhavatia17 Peptic Ulcer Disease, 170Neville D. Bamji and Ariel A. Benson18 Helicobacter pylori Treatment and Eradication, 180Anthony A. Weiss19 Gastroparesis, 193Eric S. Goldstein20 GI Complications of Obesity Surgery, 203Jonathan Z. Potack21 Tumors of the Foregut, 213Michelle Kang Kim22 Short Bowel Syndrome and Malnutrition, 222Lauren K. Schwartz and Benjamin L. Cohen23 Bacterial Overgrowth, 233Peter H. Rubin24 Celiac Disease, 238Ariel A. Benson and James Aisenberg25 Infectious Enteritis and Colitis; Bacterial Food Poisoning; Intestinal Protozoa and Helminthic Infestations, 250Jenny Sauk26 Immunodefi ciency and the GI Tract, 260Saurabh Mehandru27 GI Stromal Tumors, 270Peter E. Legnani28 Neuroendocrine Tumors, 279Richard R.P. Warner29 Pancreatitis (Acute, Chronic, Autoimmune), 292Jeffrey R. Lewis and Yuki Young30 Pancreatic Cysts and Tumors, 304Christopher J. DiMaio31 Disorders of the Biliary Tract, 323Ron Palmon and Kalpesh K. Patel32 GI Complications of Transplant, 336Vera Kandror Denmark33 Vascular Lesions of the GI Tract, 347Jose Romeu34 Irritable Bowel Syndrome, 358Charles D. Gerson35 Crohn’s Disease, 366Joana Torres and Jean-Frédéric Colombel36 Ulcerative Colitis, 379Adam F. Steinlauf and Daniel H. Present37 Complications of Restorative Proctocolectomy with Ileal Pouch-Anal Anastomosis, 390Joel J. Bauer and Stephen R. Gorfine38 Radiation Enterocolitis, 398Prashant Kedia and Adam Steinlauf39 Clostridium difficile, 411Gerald Friedman40 Ischemic Disease of the Small and Large Bowel, 422Ari Grinspan and Asher Kornbluth41 Diverticular Diseases of the Colon, 435David B. Sachar42 Adenocarcinoma of the Large Bowel and Hereditary Colon Cancer Syndromes, 443Steven H. Itzkowitz43 Colonoscopic Polypectomy, 455Jerome D. Waye44 Surveillance for Dysplasia in Inflammatory Bowel Disease, 467Thomas A. Ullman45 Diseases of the Anus and Rectum, 477Alexander J. Greenstein and Sergey Khaitov46 Complications of GI Endoscopy, 487James F. MarionIndex, 499A color plate section appears between pages 74 and 75