Francisco A. Uzal, DVM, FRVC, MSc, PhD, Dipl. ACVP, is Professor of Veterinary Diagnostic Pathology at the School of Veterinary Medicine at the University of California at Davis in San Bernardino, California, USA.J. Glenn Songer,  MA, PhD, Fellow AAM, Dipl. ACVM, is Professor (Emeritus) of Veterinary Science and Microbiology, College of Agriculture, The University of Arizona in Tucson, Arizon, USA.John F. Prescott, MA, Vet MB, PhD, FCAHS, is Professor (Emeritus) of Veterinary Microbiology at Ontario Veterinary College, University of Guelph in Ontario, Canada.Michel R. Popoff, DVM, PhD, is the head of the Research Unit of Anaerobic Bacteria and Toxins and the National Reference Center for Anaerobic Bacteria and Botulism at Institut Pasteur in Paris, France.

• List of Contributors xiPreface xviiSection 1: The pathogenic clostridia1 Taxonomic Relationships among the Clostridia 3John F. Prescott, Janet I. MacInnes, and Anson K. K. Wu2 General Physiological and Virulence Properties of the Pathogenic Clostridia 7Julian I. Rood3 Brief Description of Animal Pathogenic Clostridia 13John F. PrescottSection 2: Toxins Produced by the Pathogenic Clostridia4 Toxins of Histotoxic Clostridia: Clostridium chauvoei, Clostridium septicum, Clostridium novyi, and Clostridium sordellii 23Michel R. Popoff5 Toxins of Clostridium perfringens 45James R. Theoret and Bruce A. McClane6 Toxins of Clostridium difficile 61J. Glenn Songer, Ashley E. Harmon, and M. Kevin Keel7 Clostridium botulinum and Clostridium tetani Neurotoxins 71Michel R. PopoffSection 3: Clostridial Infections of the Gastrointestinal System8 Diseases Produced by Clostridium perfringensType A in Mammalian Species 109Francisco A. Uzal9 NetF‐Associated Necrotizing Enteritis of Foals and Canine Hemorrhagic Gastroenteritis 117Iman Mehdizadeh Gohari, Valeria R. Parreira, and John F. Prescott10 Necrotic Enteritis of Poultry 123Kerry K. Cooper and J. Glenn Songer11 Infections by Clostridium perfringens Type B 139Francisco A. Uzal and J. Glenn Songer12 Diseases Produced by Clostridium perfringens Type C 143Santiago S. Diab13 Diseases Produced by Clostridium perfringens Type D 157Francisco A. Uzal, Federico Giannitti, John W. Finnie, and Jorge P. García14 Infections by Clostridium perfringens Type E 173J. Glenn Songer15 Diseases Produced by Clostridium difficile 177Santiago S. Diab, Francisco A. Uzal, and J. Glenn Songer16 Disease Caused by Clostridium colinum: Ulcerative Enteritis of Poultry and Other Avian Species 197John F. Prescott17 Clostridial Abomasitis 205John F. Prescott, Paula I. Menzies, and Russell S. Fraser18 Diseases Produced by Clostridium spiroforme 221J. Glenn Songer and Francisco A. UzalSection 4: Clostridial Histotoxic Infections19 Blackleg 231Camila C. Abreu and Francisco A. Uzal20 Gas Gangrene (Malignant Edema) 243Rodrigo O. S. Silva, Francisco A. Uzal, Carlos A. Oliveira Jr, and Francisco C. F. Lobato21 Gangrenous Dermatitis in Poultry 255H. L. Shivaprasad22 Bacillary Hemoglobinuria 265Mauricio Navarro, Fernando Dutra Quintela, and Francisco A. Uzal23 Infectious Necrotic Hepatitis 275Mauricio Navarro and Francisco A. Uzal24 Tyzzer’s Disease 281Karina C. Fresneda and Francisco R. Carvallo ChaigneauSection 5: Clostridial Neurotoxic Infections25 Tetanus 295Michel R. Popoff26 Botulism 303Caroline Le Maréchal, Cédric Woudstra, and Patrick Fach27 Diseases Caused by Other Clostridia Producing Neurotoxins 331John F. PrescottIndex 333