Michel R. Popoff – författare

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.- Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France- 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology- Includes the major toxins of both basic and clinical interest are described in depth- Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology- Evolutionary and functional aspects of bacterial toxins evaluated and summarized- Toxin applications in cell biology presented- Therapy (cancer therapy, dystonias) discussed- Vaccines (native and genetically engineered vaccines) featured- Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology Includes the major toxins of both basic and clinical interest are described in depth Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology Evolutionary and functional aspects of bacterial toxins evaluated and summarized Toxin applications in cell biology presented Therapy (cancer therapy, dystonias) discussed Vaccines (native and genetically engineered vaccines) featured Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.

Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them Focused chapters on toxin applications and common properties or general features of toxins

The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.- Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them- Focused chapters on toxin applications and common properties or general features of toxins

Clostridial Diseases of Animals is the first book to focus on clostridial diseases in domestic and wild animals, offering a comprehensive reference on these common diseases.

Provides a single resource for all aspects of clostridial diseases Presents current, comprehensive information with a focus on clinical relevance Covers each disease in depth, including etiology, epidemiology, clinics, gross pathology, histopathology, diagnostics, diagnostic criteria, prophylaxis, control, and treatment Written by the world-leading experts in the field of clostridial diseases in animals Offers photographs and summary tables to support the concepts discussed in the text and aid in recognition

Clostridial Diseases of Animals is the first book to focus on clostridial diseases in domestic and wild animals, offering a comprehensive reference on these common diseases.

Provides a single resource for all aspects of clostridial diseases Presents current, comprehensive information with a focus on clinical relevance Covers each disease in depth, including etiology, epidemiology, clinics, gross pathology, histopathology, diagnostics, diagnostic criteria, prophylaxis, control, and treatment Written by the world-leading experts in the field of clostridial diseases in animals Offers photographs and summary tables to support the concepts discussed in the text and aid in recognition

Comprehensive and up-to-date coverage of clostridial diseases The newly revised second edition of Clostridial Diseases of Animals is a timely update to the gold-standard resource for veterinary practitioners treating clostridial disease in animals. This is a comprehensive, detailed reference that emphasizes clinically relevant information on pathogenesis, pathology, microbiology, diagnostic techniques, clinical management, and treatment. The Second Edition takes a new One Health perspective, offering brand-new chapters that cover enteric, histotoxic, and neurotoxic clostridial diseases in animals and humans. The book also explores the reclassification of C. perfringens, providing references throughout to explain the level of evidence supporting each conclusion. Inside the book: A thorough treatment of clostridial diseases with accurate coverage of new information and technologiesA reorganized gastrointestinal section reflecting the changes to the classification of C. perfringensPractical discussions of enteric, histotoxic, and neurotoxic clostridial diseasesFully cited references demonstrating the evidence baseWritten for veterinary clinicians, diagnosticians, pathologists, and microbiologists, Clostridial Diseases of Animals will also benefit regulators working in government agencies with a stake in this issue, as well as veterinary students.

Comprehensive and up-to-date coverage of clostridial diseases

The newly revised second edition of Clostridial Diseases of Animals is a timely update to the gold-standard resource for veterinary practitioners treating clostridial disease in animals. This is a comprehensive, detailed reference that emphasizes clinically relevant information on pathogenesis, pathology, microbiology, diagnostic techniques, clinical management, and treatment.

The Second Edition takes a new One Health perspective, offering brand-new chapters that cover enteric, histotoxic, and neurotoxic clostridial diseases in animals and humans. The book also explores the reclassification of C. perfringens, providing references throughout to explain the level of evidence supporting each conclusion.

Inside the book:

A thorough treatment of clostridial diseases with accurate coverage of new information and technologiesA reorganized gastrointestinal section reflecting the changes to the classification of C. perfringensPractical discussions of enteric, histotoxic, and neurotoxic clostridial diseasesFully cited references demonstrating the evidence base

Written for veterinary clinicians, diagnosticians, pathologists, and microbiologists, Clostridial Diseases of Animals will also benefit regulators working in government agencies with a stake in this issue, as well as veterinary students.

Comprehensive and up-to-date coverage of clostridial diseases The newly revised second edition of Clostridial Diseases of Animals is a timely update to the gold-standard resource for veterinary practitioners treating clostridial disease in animals. This is a comprehensive, detailed reference that emphasizes clinically relevant information on pathogenesis, pathology, microbiology, diagnostic techniques, clinical management, and treatment. The Second Edition takes a new One Health perspective, offering brand-new chapters that cover enteric, histotoxic, and neurotoxic clostridial diseases in animals and humans. The book also explores the reclassification of C. perfringens, providing references throughout to explain the level of evidence supporting each conclusion. Inside the book: A thorough treatment of clostridial diseases with accurate coverage of new information and technologiesA reorganized gastrointestinal section reflecting the changes to the classification of C. perfringensPractical discussions of enteric, histotoxic, and neurotoxic clostridial diseasesFully cited references demonstrating the evidence base Written for veterinary clinicians, diagnosticians, pathologists, and microbiologists, Clostridial Diseases of Animals will also benefit regulators working in government agencies with a stake in this issue, as well as veterinary students.