Antineoplastic Drugs

Dr Daniel Lednicer's career in both the private and public sectors has been devoted to the search for new therapeutic agents. He spent two decades at the bench as a chemist at the Upjohn Company. Following that, he served as director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. Most recently, he was a project officer at the National Cancer Institute. Dr Lednicer is the acclaimed author of several books on drug synthesis and discovery, including 7 volumes of the series Organic Chemistry of Drug Synthesis (Wiley US).

• Preface ixIntroduction xi1 Alkylating Agents 11.1 bis-Chloroethyl Amines 11.2 Several Other Chloroethyl Agents 51.3 Platinum-Based Antineoplastic Agents 61.4 Miscellaneous Alkylating Agents 82 Antimetabolites 132.1 Introduction 132.2 Folate Antagonists 142.3 Pyrimidines and Purines 213 Hormone Blocking Anticancer Drugs 313.1 Introduction 313.2 Estrogen Antagonists 323.3 Androgen Antagonists 444 Topoisomerase Inhibitors 554.1 Introduction 554.2 Anthracyclines 564.3 Anthraquinones and Anthrapyrazoles 594.4 Camptothecins 654.5 Miscellaneous Topoisomerase Inhibitors 745 Mitotic Inhibitors 815.1 Introduction 815.2 Taxanes 825.3 Wholly Synthetic Compounds 866 Matrix Metalloproteinase Inhibitors 976.1 Introduction 976.2 Hydroxamates 987 Histone Deacetylase Inhibitors 1097.1 Introduction 1097.2 Hydroxamates 1107.3 Phenylenediamines 1138 Enzyme Inhibitor, Part I, Tyrosine Kinases 1178.1 Introduction 1178.2 Epidermal Growth Factor Inhibitors 1188.3 VEGF 1248.4 SRC Nonreceptor Tyrosine Kinase 1348.5 PDGF 1388.6 EGF 1418.7 Other TKI 1438.8 Janus Kinase Inhibitors 1549 Enzyme Inhibitors: Part II Additional Targets 1619.1 Serine–Threonine Kinase Inhibitors 1619.2 Additional Enzyme Inhibitors 16610 Miscellaneous Antineoplastic Agents 18710.1 Acyclic 18710.2 Monocyclic 18810.3 Two Linked Rings 19010.4 Rings on a Chain 19110.5 Fused Rings 195Appendix A 203Combinatorial Chemistry 203Index of Heterocyclic Sytheses 205Subject Index 207