David B. Adams, M.D. is Professor and Chief of Gastrointestinal and Laparoscopic Surgery and Co-Director of the Digestive Disease Center at the Medical University of South Carolina, Charleston, South Carolina. He is the author of over 100 manuscripts and book chapters which deal with his academic and clinical research interests in chronic pancreatitis.Peter B. Cotton, M.D. is a British Gastroenterologist best known for his advancement in digestive disease, pioneering and naming the ERCP procedure and creating the Digestive Disease Center at the Medical University of South Carolina where he is Professor of Medicine. He has been active in National and International organizations, and has given invited lectures and demonstrations in more than 50 countries His bibliography includes over 900 medical publications, including more than 300 original contributions in peer reviewed journals, and 10 books.Nicholas J. Zyromski, M.D. is Associate Professor of Surgery at Indiana University. He served as an NIH research fellow at the Mayo Clinic in Rochester, Minnesota, and is currently the Indiana University HPB Surgery Fellowship Program Director. Dr. Zyromski’s principal clinical interest is in pancreatic disease; his basic and translational research interest focuses on the inflammatory response of acute pancreatitis as well as the influence of obesity and adipose tissue on pancreatic diseases — pancreatic cancer and acute pancreatitis.John Windsor, M.D. holds a personal chair in surgery at the University of New Zealand, Auckland. He is Director of Surgical Research, Director of Surgical Research Network , Co-Director of Applied Surgery and Metabolism Laboratory and Surgical Centre for Outcomes Research and Evaluation, Principle Investigator Pancreas Research Group, and Associate Investigator Maurice Wilkins Centre of Biodiscovery. His primary research is in the pathophysiology and clinical management of acute and chronic pancreatitis. He is Associate Editor of the journal Pancreatology and the World Journal of Surgery.

"Overall, this is an excellent book on all aspects of acute and chronic pancreatitis. It is concise yet comprehensive, written by well-known and well-published, credible authorities. It will be useful not just to the intended audience of gastroenterologists and GI surgeons, but also to all physicians involved in the care of patients with pancreatitis. Most books try to cover all aspects of this complex condition in a summary fashion, which is not possible. This book fills in the gaps by providing a focused, comprehensive review including latest evidence and guidelines. 5 Stars!" (Doody Enterprises July 2017)"This is a definitive and authoritative work that is quite manageable to read, understand and process.Because of that, a reader will return to it often, extending its benefits. Pancreatitis is challengingenough without having what this book provides. This excellent contribution has indeed refreshed andadvanced my own knowledge-base by performing this review. Even the most seasoned practitioner cangarner value in its pages, and again, return to it often" Charles M. Vollmer, Jr, MD, Professor of Surgery, University of Pennsylvania Perelman School of Medicine on behalf of HPB, Summer 2017

• List of contributors, vii1 Epidemiology and genetics of chronic pancreatitis, 12A Pathobiology of the acinar cell in acute pancreatitis, 102B Locoregional pathophysiology in acute pancreatitis: pancreas and intestine, 192C Pathophysiology of systemic inflammatory response syndrome and multiorgan dysfunction syndrome in acute pancreatitis, 293 Diagnosis, prediction, and classification, 384 Medical treatment, 475 Nutritional treatment in acute pancreatitis, 556 Gallstone pancreatitis: diagnosis and treatment, 647 Treatment of local complications, 758 Treatment of systemic complications and organ failure, 859 Specific treatment for acute pancreatitis, 9110 Sequelae of acute pancreatitis, 10111 History of chronic pancreatitis, 11312A Epidemiology and pathophysiology: epidemiology and risk factors, 11812B Epidemiology and pathophysiology: genetic insights into pathogenesis, 12612C Pancreatic stellate cells: what do they tell us about chronic pancreatitis?, 14312D Autoimmune pancreatitis: an update, 15212E Etiology and pathophysiology: tropical pancreatitis, 16112F Mechanisms and pathways of pain in chronic pancreatitis, 16913A Imaging of chronic pancreatitis, 17913B Endoscopic ultrasonography in chronic pancreatitis, 18814A Pancreatic enzyme replacement therapy (PERT), 19514B Nutritional treatment: antioxidant treatment, 20514C Pancreatogenic diabetes: etiology, implications, and management, 21114D Nutrition without a pancreas: how does the gut do it?, 22515A Endoscopic management of chronic pancreatitis, 23315B Shocking and fragmenting pancreatic ductal stones, 24515C Endoscopic management: celiac plexus blockade, 24916A A brief history of modern surgery for chronic pancreatitis, 25616B Surgery for chronic pancreatitis: indications and timing of surgery, 26116C Chronic pancreatitis: surgical strategy in complicated diseases, 26516D Surgery for chronic pancreatitis: pancreatic duct drainage procedures, 27316E Surgical management: resection and drainage procedures, 27916F The role of pancreatoduodenectomy in the management of chronic pancreatitis, 28617A Total pancreatectomy and islet cell autotransplantation: patient selection, 29517B Total pancreatectomy and islet cell autotransplantation: the science of islet cell preservation, from pancreas to liver, 29917C Total pancreatectomy and islet cell autotransplantation: long-term assessment of graft function, 308Index, 321