About the Editors Yiu-chung Wong, Analytical and Advisory Services Division, Government Laboratory, Hong Kong Richard J. Lewis, Institute for Molecular Bioscience, The University of Queensland, Australia

• List of Contributors ixForeword xviiPreface xixVolume 1Section I: Recent Analytical Technology for Food Pathogens and Toxins 11 Omic Analysis of Protein and Peptide Toxins in Food 3Pasquale Ferranti, Chiara Nitride, and Monica Gallo2 Biotechnology-Based Sensing Platforms for Detecting Foodborne Pathogens 37Akbar S. Khan3 Review of Sample Treatments and the State-of-the-art of Analytical Techniques for Mycotoxins in Food 51Natalia Arroyo-Manzanares, José F. Huertas-Pérez, Ana M. García-Campaña, and Laura Gámiz-Gracia4 Isothermal Nucleic Acid Amplification for Food Toxicity Analyses 103Luis A. Tortajada-Genaro, S. Santiago-Felipe, and Angel MaquieiraSection II: Microbial and Plant Toxins 1375 Determination of Mycotoxins in Food 139Muhammad Azhar Hayat Nawaz, Sajid Rauf, Akhtar Hayat, Gaelle Catanante, Rizwan Raza, and Jean-Louis Marty6 Mycotoxins Detection in Asia 169Chee Wei Lim, Angela Li, and Joanne Sheot Harn Chan7 Surface Plasmon Resonance Analysis of Food Toxins and Toxicants 195Valerija Vezočnik, Vesna Hodnik, and Gregor Anderluh8 Food Poisoning Case Studies: Mushroom and Pufferfish Toxin Investigation 217Samuel Tsz-chun Cheung, Winnie Wing-yan Chum, Wai-yan Ha, Pui-kwan Chan, and Tin-yau Law9 The Analysis of Pyrrolizidine Alkaloids in Honey 237Colin Crews and Till Beuerle10 Pyrrolizidine Alkaloids in Food: Analytical, Toxicological and Health Considerations 267Caroline T. Griffin, Aisling Sheehan, Martin Danaher, and Ambrose FureyVolume 2Section III: Marine Toxins 31911 The Determination of Marine Biotoxins in Seafood 321Arjen Gerssen and Mirjam D. Klijnstra12 Detection of Paralytic Shellfish Poisoning Toxins in Molluscs 363Stephen Burrell and Andrew D. Turner13 Determination of Saxitoxin and Tetrodotoxin in Fish 403Sara C. McGrath and Jonathan R. Deeds14 Determination of Saxitoxin, Tetrodotoxin and Common Phycotoxins 431Luis M. Botana, Amparo Alfonso, Mercedes R. Vieytes, M. Carmen Louzao, Ana M. Botana, Carmen Vale, and Natalia Vilariño15 Ciguatoxin Detection Methods and High-Throughput Assays 469Marco Inserra, Yelena Lavrukhina, Alun Jones, Richard J. Lewis, and Irina VetterSection IV: Biogenic Amines and Common Food Toxicants 48916 Detection of Histamine Based on Biosensor System 491Takeshi Ito17 Flow-based Technology for Analysis of Food Pesticides 505Antonio Ruiz-Medina, Eulogio J. Llorent-Martínez, María Luisa Fernández-de Córdova, and Pilar Ortega-Barrales18 Residual Pesticides and Heavy Metals Analysis in Food 537Sameeh A. Mansour19 Microarray Methodologies for Pesticides and Other Toxins in Foods 571Xiaofeng Hu, Suiyan Ouyang, Peiwu Li, Qi Zhang, Xianfeng Ren, Huali Xie, and Zhaowei ZhangSection V: Quality Assurance and Regulatory Development 59320 Accreditation, a Key Recognition for the Analysis of Food Toxins and Contaminants 595Wang-wah Wong21 Quality Assurance and Control for Accurate Measurement of Food Toxins 621Alan Richards22 Analytical Methods and Development of Reference Materials for Toxic Metals and Metal Species in Food and Dietary Supplements 639Stephen E. Long, Michael Ellisor, Frances Nilsen, Laura Wood, Karen Murphy, and Lee Yu23 Overview of Toxins and Toxicants in Food and Their Regulatory Limits 679Peter A. Brown24 Food Allergy: Managing Food Allergens 711Michael J. Walker and M. Hazel GowlandIndex 743

About the Editors Yiu-chung Wong, Analytical and Advisory Services Division, Government Laboratory, Hong Kong Richard J. Lewis, Institute for Molecular Bioscience, The University of Queensland, Australia

• List of Contributors ixForeword xviiPreface xixVolume 1Section I: Recent Analytical Technology for Food Pathogens and Toxins 11 Omic Analysis of Protein and Peptide Toxins in Food 3Pasquale Ferranti, Chiara Nitride, and Monica Gallo2 Biotechnology-Based Sensing Platforms for Detecting Foodborne Pathogens 37Akbar S. Khan3 Review of Sample Treatments and the State-of-the-art of Analytical Techniques for Mycotoxins in Food 51Natalia Arroyo-Manzanares, José F. Huertas-Pérez, Ana M. García-Campaña, and Laura Gámiz-Gracia4 Isothermal Nucleic Acid Amplification for Food Toxicity Analyses 103Luis A. Tortajada-Genaro, S. Santiago-Felipe, and Angel MaquieiraSection II: Microbial and Plant Toxins 1375 Determination of Mycotoxins in Food 139Muhammad Azhar Hayat Nawaz, Sajid Rauf, Akhtar Hayat, Gaelle Catanante, Rizwan Raza, and Jean-Louis Marty6 Mycotoxins Detection in Asia 169Chee Wei Lim, Angela Li, and Joanne Sheot Harn Chan7 Surface Plasmon Resonance Analysis of Food Toxins and Toxicants 195Valerija Vezočnik, Vesna Hodnik, and Gregor Anderluh8 Food Poisoning Case Studies: Mushroom and Pufferfish Toxin Investigation 217Samuel Tsz-chun Cheung, Winnie Wing-yan Chum, Wai-yan Ha, Pui-kwan Chan, and Tin-yau Law9 The Analysis of Pyrrolizidine Alkaloids in Honey 237Colin Crews and Till Beuerle10 Pyrrolizidine Alkaloids in Food: Analytical, Toxicological and Health Considerations 267Caroline T. Griffin, Aisling Sheehan, Martin Danaher, and Ambrose FureyVolume 2Section III: Marine Toxins 31911 The Determination of Marine Biotoxins in Seafood 321Arjen Gerssen and Mirjam D. Klijnstra12 Detection of Paralytic Shellfish Poisoning Toxins in Molluscs 363Stephen Burrell and Andrew D. Turner13 Determination of Saxitoxin and Tetrodotoxin in Fish 403Sara C. McGrath and Jonathan R. Deeds14 Determination of Saxitoxin, Tetrodotoxin and Common Phycotoxins 431Luis M. Botana, Amparo Alfonso, Mercedes R. Vieytes, M. Carmen Louzao, Ana M. Botana, Carmen Vale, and Natalia Vilariño15 Ciguatoxin Detection Methods and High-Throughput Assays 469Marco Inserra, Yelena Lavrukhina, Alun Jones, Richard J. Lewis, and Irina VetterSection IV: Biogenic Amines and Common Food Toxicants 48916 Detection of Histamine Based on Biosensor System 491Takeshi Ito17 Flow-based Technology for Analysis of Food Pesticides 505Antonio Ruiz-Medina, Eulogio J. Llorent-Martínez, María Luisa Fernández-de Córdova, and Pilar Ortega-Barrales18 Residual Pesticides and Heavy Metals Analysis in Food 537Sameeh A. Mansour19 Microarray Methodologies for Pesticides and Other Toxins in Foods 571Xiaofeng Hu, Suiyan Ouyang, Peiwu Li, Qi Zhang, Xianfeng Ren, Huali Xie, and Zhaowei ZhangSection V: Quality Assurance and Regulatory Development 59320 Accreditation, a Key Recognition for the Analysis of Food Toxins and Contaminants 595Wang-wah Wong21 Quality Assurance and Control for Accurate Measurement of Food Toxins 621Alan Richards22 Analytical Methods and Development of Reference Materials for Toxic Metals and Metal Species in Food and Dietary Supplements 639Stephen E. Long, Michael Ellisor, Frances Nilsen, Laura Wood, Karen Murphy, and Lee Yu23 Overview of Toxins and Toxicants in Food and Their Regulatory Limits 679Peter A. Brown24 Food Allergy: Managing Food Allergens 711Michael J. Walker and M. Hazel GowlandIndex 743

About the Editors Yiu-chung Wong, Analytical and Advisory Services Division, Government Laboratory, Hong Kong Richard J. Lewis, Institute for Molecular Bioscience, The University of Queensland, Australia

• List of Contributors ixForeword xviiPreface xixVolume 1Section I: Recent Analytical Technology for Food Pathogens and Toxins 11 Omic Analysis of Protein and Peptide Toxins in Food 3Pasquale Ferranti, Chiara Nitride, and Monica Gallo2 Biotechnology-Based Sensing Platforms for Detecting Foodborne Pathogens 37Akbar S. Khan3 Review of Sample Treatments and the State-of-the-art of Analytical Techniques for Mycotoxins in Food 51Natalia Arroyo-Manzanares, José F. Huertas-Pérez, Ana M. García-Campaña, and Laura Gámiz-Gracia4 Isothermal Nucleic Acid Amplification for Food Toxicity Analyses 103Luis A. Tortajada-Genaro, S. Santiago-Felipe, and Angel MaquieiraSection II: Microbial and Plant Toxins 1375 Determination of Mycotoxins in Food 139Muhammad Azhar Hayat Nawaz, Sajid Rauf, Akhtar Hayat, Gaelle Catanante, Rizwan Raza, and Jean-Louis Marty6 Mycotoxins Detection in Asia 169Chee Wei Lim, Angela Li, and Joanne Sheot Harn Chan7 Surface Plasmon Resonance Analysis of Food Toxins and Toxicants 195Valerija Vezočnik, Vesna Hodnik, and Gregor Anderluh8 Food Poisoning Case Studies: Mushroom and Pufferfish Toxin Investigation 217Samuel Tsz-chun Cheung, Winnie Wing-yan Chum, Wai-yan Ha, Pui-kwan Chan, and Tin-yau Law9 The Analysis of Pyrrolizidine Alkaloids in Honey 237Colin Crews and Till Beuerle10 Pyrrolizidine Alkaloids in Food: Analytical, Toxicological and Health Considerations 267Caroline T. Griffin, Aisling Sheehan, Martin Danaher, and Ambrose FureyVolume 2Section III: Marine Toxins 31911 The Determination of Marine Biotoxins in Seafood 321Arjen Gerssen and Mirjam D. Klijnstra12 Detection of Paralytic Shellfish Poisoning Toxins in Molluscs 363Stephen Burrell and Andrew D. Turner13 Determination of Saxitoxin and Tetrodotoxin in Fish 403Sara C. McGrath and Jonathan R. Deeds14 Determination of Saxitoxin, Tetrodotoxin and Common Phycotoxins 431Luis M. Botana, Amparo Alfonso, Mercedes R. Vieytes, M. Carmen Louzao, Ana M. Botana, Carmen Vale, and Natalia Vilariño15 Ciguatoxin Detection Methods and High-Throughput Assays 469Marco Inserra, Yelena Lavrukhina, Alun Jones, Richard J. Lewis, and Irina VetterSection IV: Biogenic Amines and Common Food Toxicants 48916 Detection of Histamine Based on Biosensor System 491Takeshi Ito17 Flow-based Technology for Analysis of Food Pesticides 505Antonio Ruiz-Medina, Eulogio J. Llorent-Martínez, María Luisa Fernández-de Córdova, and Pilar Ortega-Barrales18 Residual Pesticides and Heavy Metals Analysis in Food 537Sameeh A. Mansour19 Microarray Methodologies for Pesticides and Other Toxins in Foods 571Xiaofeng Hu, Suiyan Ouyang, Peiwu Li, Qi Zhang, Xianfeng Ren, Huali Xie, and Zhaowei ZhangSection V: Quality Assurance and Regulatory Development 59320 Accreditation, a Key Recognition for the Analysis of Food Toxins and Contaminants 595Wang-wah Wong21 Quality Assurance and Control for Accurate Measurement of Food Toxins 621Alan Richards22 Analytical Methods and Development of Reference Materials for Toxic Metals and Metal Species in Food and Dietary Supplements 639Stephen E. Long, Michael Ellisor, Frances Nilsen, Laura Wood, Karen Murphy, and Lee Yu23 Overview of Toxins and Toxicants in Food and Their Regulatory Limits 679Peter A. Brown24 Food Allergy: Managing Food Allergens 711Michael J. Walker and M. Hazel GowlandIndex 743