Adrian C Bateman is a Consultant in Histopathology at University Hospital Southampton, UK. Joel K Greenson is Professor of Pathology at the University of Michigan, USA. Gregory Y Lauwers is Professor of Pathology at Harvard Medical School, USA. Maurice B Loughrey is a consultant gastrointestinal pathologist in the Royal Victoria Hospital, Belfast, UK. Marco R Novelli is Professor of GI Pathology and Consultant Histopathologist, University College London Hospital, UK. Kieran Sheahan is Consultant Histopathologist at St. Vincent’s University Hospital, Dublin, Ireland. Neil A Shepherd is Professor of Gastrointestinal Pathology and Consultant Histopathologist at Gloucestershire Royal and Cheltenham General Hospitals, Gloucestershire, England, UK.

• Contributors ixForeword xiiiPreface and Acknowledgements xvAbout the companion website xviiPart 1 Oesophagus1 The normal oesophagus: anatomy, specimen dissection and histology relevant to pathologicalpractice 3Kaiyo Takubo and Neil A Shepherd2 Normal embryology, foetal development and developmental abnormalities 13Kaiyo Takubo and Neil A Shepherd3 Neuromuscular and mechanical disorders of the oesophagus 21D Scott A Sanders4 Inflammatory disorders of the oesophagus 29Laura Webb Lamps5 Barrett’s oesophagus 45Marnix Jansen and Neil A Shepherd6 Polyps and tumour-like lesions of the oesophagus 61Jeremy R Parfitt and David K Driman7 Tumours of the oesophagus 67Mikhail Lisovsky and Amitabh Srivastava8 Miscellaneous conditions of the oesophagus 103Raymond F T McMahonPart 2 Stomach9 The normal stomach: anatomy, histology, and specimen dissection relevant to pathological practice111Shinichi Ban10 The stomach: normal embryology, foetal development and developmental abnormalities 129Michio Shimizu and Do-Youn Park11 Inflammatory disorders of the stomach 135Won-Tak Choi, Gregory Y Lauwers and Tomas Slavik12 Polyps and tumour-like lesions of the stomach 195Paul Kelly and Gregory Y Lauwers13 Epithelial tumours of the stomach 227Bence Kõvári, Fátima Carneiro and Gregory Y Lauwers14 Stromal tumours of the stomach 287Erinn Downs, Brian P Rubin and John R Goldblum15 Lymphoid tumours of the stomach 313Laurence de Leval, Michaël Lévy and Christiane Copie-Bergman16 Miscellaneous conditions of the stomach 347Do-Youn Park, Bence Kővári and Michio ShimizuPart 3 Small Intestine17 Normal small intestine: anatomy, specimen dissection and histology relevant to pathologicalpractice 361Philip V Kaye18 Congenital abnormalities of the small intestine 373Elise Gradhand and Newton A C S Wong19 Neuromuscular and mechanical disorders of the small bowel 385Joanne E Martin and Pascale Capleton Copyrighted Material20 Inflammatory disorders of the small intestine 397Karel Geboes and Anne Jouret-Mourin21 The pathology of malnutrition and malabsorption 463Ian Brown22 Vascular disorders of the small intestine 493Rhonda K Yantiss23 Polyps and tumour-like lesions of the small intestine 513Marnix Jansen, Lodewijk A A Brosens and G Johan A Offerhaus24 Malignant epithelial tumours of the small intestine 525Aoife J McCarthy and Kieran Sheahan25 Mesenchymal tumours of the small intestine 551Elizabeth Montgomery and Kieran Sheahan26 Lymphoid tumours of the small intestine 579Laurence de Leval and Govind Bhagat27 Miscellaneous disorders of the small intestine 607Joel K GreensonPart 4 Appendix28 Normal appendix: anatomy, specimen dissection and histology relevant to pathological practice615Norman J Carr29 Inflammatory disorders of the appendix 621Rhonda K Yantiss30 Tumours of the appendix 635Norman J Carr and Mark J Arends31 Miscellaneous conditions of the appendix 651David K Worrall and Mark J ArendsPart 5 Large Intestine32 Normal large intestine: anatomy, specimen dissection and histology relevant to pathologicalpractice 661Gordon G A Hutchins, Caroline Young, Kate Marks, Nicholas P West and Phil Quirke33 Embryogenesis and developmental abnormalities (including the anal region) 677Adrian C Bateman34 Muscular and mechanical disorders of the large intestine 687Joanne E Martin35 Inflammatory disorders of the large intestine 709Roger M Feakins36 Vascular disorders of the large intestine 859Cian Muldoon37 Polyps, polyposis syndromes and tumour-like lesions of the large intestine 871Christophe Rosty, Mark L Bettington and Andrew D Clouston38 Malignant epithelial neoplasms of the large intestine 925Shaun V Walsh, Kieran Sheahan and Frank A Carey39 Mesenchymal tumours of the large intestine 969Jean-François Fléjou40 Lymphoid tumours of the large intestine 981Laurence de Leval, Govind Bhagat and Christiane Copie-Bergman41 Miscellaneous disorders of the large intestine 991Adrian C BatemanPart 6 The Anus42 Normal anal region: anatomy, histology relevant to pathology practice and specimen handling1003Lai Mun Wang43 Inflammatory disorders of the anal region 1009Miriam Mitchison and Marco R Novelli44 Tumours and tumour-like conditions of the anus 1017Newton A C S Wong45 Miscellaneous conditions of the anal region 1045Manuel Salto-Tellez and Marco R NovelliPart 7 Peritoneum46 The normal peritoneum: anatomy and histology 1053Maurice B Loughrey47 Inflammatory disorders of the peritoneum 1057Maurice B Loughrey48 Tumours and tumour-like lesions of the peritoneum 1073Norman J Carr and Maurice B Loughrey49 Miscellaneous conditions of the peritoneum 1095Maurice B LoughreyIndex 1099

Adrian C Bateman is a Consultant in Histopathology at University Hospital Southampton, UK. Joel K Greenson is Professor of Pathology at the University of Michigan, USA. Gregory Y Lauwers is Professor of Pathology at Harvard Medical School, USA. Maurice B Loughrey is a consultant gastrointestinal pathologist in the Royal Victoria Hospital, Belfast, UK. Marco R Novelli is Professor of GI Pathology and Consultant Histopathologist, University College London Hospital, UK. Kieran Sheahan is Consultant Histopathologist at St. Vincent’s University Hospital, Dublin, Ireland. Neil A Shepherd is Professor of Gastrointestinal Pathology and Consultant Histopathologist at Gloucestershire Royal and Cheltenham General Hospitals, Gloucestershire, England, UK.

• Contributors ixForeword xiiiPreface and Acknowledgements xvAbout the companion website xviiPart 1 Oesophagus1 The normal oesophagus: anatomy, specimen dissection and histology relevant to pathologicalpractice 3Kaiyo Takubo and Neil A Shepherd2 Normal embryology, foetal development and developmental abnormalities 13Kaiyo Takubo and Neil A Shepherd3 Neuromuscular and mechanical disorders of the oesophagus 21D Scott A Sanders4 Inflammatory disorders of the oesophagus 29Laura Webb Lamps5 Barrett’s oesophagus 45Marnix Jansen and Neil A Shepherd6 Polyps and tumour-like lesions of the oesophagus 61Jeremy R Parfitt and David K Driman7 Tumours of the oesophagus 67Mikhail Lisovsky and Amitabh Srivastava8 Miscellaneous conditions of the oesophagus 103Raymond F T McMahonPart 2 Stomach9 The normal stomach: anatomy, histology, and specimen dissection relevant to pathological practice111Shinichi Ban10 The stomach: normal embryology, foetal development and developmental abnormalities 129Michio Shimizu and Do-Youn Park11 Inflammatory disorders of the stomach 135Won-Tak Choi, Gregory Y Lauwers and Tomas Slavik12 Polyps and tumour-like lesions of the stomach 195Paul Kelly and Gregory Y Lauwers13 Epithelial tumours of the stomach 227Bence Kõvári, Fátima Carneiro and Gregory Y Lauwers14 Stromal tumours of the stomach 287Erinn Downs, Brian P Rubin and John R Goldblum15 Lymphoid tumours of the stomach 313Laurence de Leval, Michaël Lévy and Christiane Copie-Bergman16 Miscellaneous conditions of the stomach 347Do-Youn Park, Bence Kővári and Michio ShimizuPart 3 Small Intestine17 Normal small intestine: anatomy, specimen dissection and histology relevant to pathologicalpractice 361Philip V Kaye18 Congenital abnormalities of the small intestine 373Elise Gradhand and Newton A C S Wong19 Neuromuscular and mechanical disorders of the small bowel 385Joanne E Martin and Pascale Capleton Copyrighted Material20 Inflammatory disorders of the small intestine 397Karel Geboes and Anne Jouret-Mourin21 The pathology of malnutrition and malabsorption 463Ian Brown22 Vascular disorders of the small intestine 493Rhonda K Yantiss23 Polyps and tumour-like lesions of the small intestine 513Marnix Jansen, Lodewijk A A Brosens and G Johan A Offerhaus24 Malignant epithelial tumours of the small intestine 525Aoife J McCarthy and Kieran Sheahan25 Mesenchymal tumours of the small intestine 551Elizabeth Montgomery and Kieran Sheahan26 Lymphoid tumours of the small intestine 579Laurence de Leval and Govind Bhagat27 Miscellaneous disorders of the small intestine 607Joel K GreensonPart 4 Appendix28 Normal appendix: anatomy, specimen dissection and histology relevant to pathological practice615Norman J Carr29 Inflammatory disorders of the appendix 621Rhonda K Yantiss30 Tumours of the appendix 635Norman J Carr and Mark J Arends31 Miscellaneous conditions of the appendix 651David K Worrall and Mark J ArendsPart 5 Large Intestine32 Normal large intestine: anatomy, specimen dissection and histology relevant to pathologicalpractice 661Gordon G A Hutchins, Caroline Young, Kate Marks, Nicholas P West and Phil Quirke33 Embryogenesis and developmental abnormalities (including the anal region) 677Adrian C Bateman34 Muscular and mechanical disorders of the large intestine 687Joanne E Martin35 Inflammatory disorders of the large intestine 709Roger M Feakins36 Vascular disorders of the large intestine 859Cian Muldoon37 Polyps, polyposis syndromes and tumour-like lesions of the large intestine 871Christophe Rosty, Mark L Bettington and Andrew D Clouston38 Malignant epithelial neoplasms of the large intestine 925Shaun V Walsh, Kieran Sheahan and Frank A Carey39 Mesenchymal tumours of the large intestine 969Jean-François Fléjou40 Lymphoid tumours of the large intestine 981Laurence de Leval, Govind Bhagat and Christiane Copie-Bergman41 Miscellaneous disorders of the large intestine 991Adrian C BatemanPart 6 The Anus42 Normal anal region: anatomy, histology relevant to pathology practice and specimen handling1003Lai Mun Wang43 Inflammatory disorders of the anal region 1009Miriam Mitchison and Marco R Novelli44 Tumours and tumour-like conditions of the anus 1017Newton A C S Wong45 Miscellaneous conditions of the anal region 1045Manuel Salto-Tellez and Marco R NovelliPart 7 Peritoneum46 The normal peritoneum: anatomy and histology 1053Maurice B Loughrey47 Inflammatory disorders of the peritoneum 1057Maurice B Loughrey48 Tumours and tumour-like lesions of the peritoneum 1073Norman J Carr and Maurice B Loughrey49 Miscellaneous conditions of the peritoneum 1095Maurice B LoughreyIndex 1099

Adrian C Bateman is a Consultant in Histopathology at University Hospital Southampton, UK. Joel K Greenson is Professor of Pathology at the University of Michigan, USA. Gregory Y Lauwers is Professor of Pathology at Harvard Medical School, USA. Maurice B Loughrey is a consultant gastrointestinal pathologist in the Royal Victoria Hospital, Belfast, UK. Marco R Novelli is Professor of GI Pathology and Consultant Histopathologist, University College London Hospital, UK. Kieran Sheahan is Consultant Histopathologist at St. Vincent’s University Hospital, Dublin, Ireland. Neil A Shepherd is Professor of Gastrointestinal Pathology and Consultant Histopathologist at Gloucestershire Royal and Cheltenham General Hospitals, Gloucestershire, England, UK.

• Contributors ixForeword xiiiPreface and Acknowledgements xvAbout the companion website xviiPart 1 Oesophagus1 The normal oesophagus: anatomy, specimen dissection and histology relevant to pathologicalpractice 3Kaiyo Takubo and Neil A Shepherd2 Normal embryology, foetal development and developmental abnormalities 13Kaiyo Takubo and Neil A Shepherd3 Neuromuscular and mechanical disorders of the oesophagus 21D Scott A Sanders4 Inflammatory disorders of the oesophagus 29Laura Webb Lamps5 Barrett’s oesophagus 45Marnix Jansen and Neil A Shepherd6 Polyps and tumour-like lesions of the oesophagus 61Jeremy R Parfitt and David K Driman7 Tumours of the oesophagus 67Mikhail Lisovsky and Amitabh Srivastava8 Miscellaneous conditions of the oesophagus 103Raymond F T McMahonPart 2 Stomach9 The normal stomach: anatomy, histology, and specimen dissection relevant to pathological practice111Shinichi Ban10 The stomach: normal embryology, foetal development and developmental abnormalities 129Michio Shimizu and Do-Youn Park11 Inflammatory disorders of the stomach 135Won-Tak Choi, Gregory Y Lauwers and Tomas Slavik12 Polyps and tumour-like lesions of the stomach 195Paul Kelly and Gregory Y Lauwers13 Epithelial tumours of the stomach 227Bence Kõvári, Fátima Carneiro and Gregory Y Lauwers14 Stromal tumours of the stomach 287Erinn Downs, Brian P Rubin and John R Goldblum15 Lymphoid tumours of the stomach 313Laurence de Leval, Michaël Lévy and Christiane Copie-Bergman16 Miscellaneous conditions of the stomach 347Do-Youn Park, Bence Kővári and Michio ShimizuPart 3 Small Intestine17 Normal small intestine: anatomy, specimen dissection and histology relevant to pathologicalpractice 361Philip V Kaye18 Congenital abnormalities of the small intestine 373Elise Gradhand and Newton A C S Wong19 Neuromuscular and mechanical disorders of the small bowel 385Joanne E Martin and Pascale Capleton Copyrighted Material20 Inflammatory disorders of the small intestine 397Karel Geboes and Anne Jouret-Mourin21 The pathology of malnutrition and malabsorption 463Ian Brown22 Vascular disorders of the small intestine 493Rhonda K Yantiss23 Polyps and tumour-like lesions of the small intestine 513Marnix Jansen, Lodewijk A A Brosens and G Johan A Offerhaus24 Malignant epithelial tumours of the small intestine 525Aoife J McCarthy and Kieran Sheahan25 Mesenchymal tumours of the small intestine 551Elizabeth Montgomery and Kieran Sheahan26 Lymphoid tumours of the small intestine 579Laurence de Leval and Govind Bhagat27 Miscellaneous disorders of the small intestine 607Joel K GreensonPart 4 Appendix28 Normal appendix: anatomy, specimen dissection and histology relevant to pathological practice615Norman J Carr29 Inflammatory disorders of the appendix 621Rhonda K Yantiss30 Tumours of the appendix 635Norman J Carr and Mark J Arends31 Miscellaneous conditions of the appendix 651David K Worrall and Mark J ArendsPart 5 Large Intestine32 Normal large intestine: anatomy, specimen dissection and histology relevant to pathologicalpractice 661Gordon G A Hutchins, Caroline Young, Kate Marks, Nicholas P West and Phil Quirke33 Embryogenesis and developmental abnormalities (including the anal region) 677Adrian C Bateman34 Muscular and mechanical disorders of the large intestine 687Joanne E Martin35 Inflammatory disorders of the large intestine 709Roger M Feakins36 Vascular disorders of the large intestine 859Cian Muldoon37 Polyps, polyposis syndromes and tumour-like lesions of the large intestine 871Christophe Rosty, Mark L Bettington and Andrew D Clouston38 Malignant epithelial neoplasms of the large intestine 925Shaun V Walsh, Kieran Sheahan and Frank A Carey39 Mesenchymal tumours of the large intestine 969Jean-François Fléjou40 Lymphoid tumours of the large intestine 981Laurence de Leval, Govind Bhagat and Christiane Copie-Bergman41 Miscellaneous disorders of the large intestine 991Adrian C BatemanPart 6 The Anus42 Normal anal region: anatomy, histology relevant to pathology practice and specimen handling1003Lai Mun Wang43 Inflammatory disorders of the anal region 1009Miriam Mitchison and Marco R Novelli44 Tumours and tumour-like conditions of the anus 1017Newton A C S Wong45 Miscellaneous conditions of the anal region 1045Manuel Salto-Tellez and Marco R NovelliPart 7 Peritoneum46 The normal peritoneum: anatomy and histology 1053Maurice B Loughrey47 Inflammatory disorders of the peritoneum 1057Maurice B Loughrey48 Tumours and tumour-like lesions of the peritoneum 1073Norman J Carr and Maurice B Loughrey49 Miscellaneous conditions of the peritoneum 1095Maurice B LoughreyIndex 1099