About the Editor JAMES A. RADOSEVICH, PH. D. is a Professor and Staff Research Scientist at the University of Illinois, Dental College and Cancer Center/VA, Chicago Health Care System. He is also an Affiliate Professor at Roosevelt University, College of Pharmacy, Department of Biopharmaceutical Sciences, USA.

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• List of Contributors ixVolume 11 General View of the Cytoplasmic and Nuclear Features of Apoptosis 1Humberto De Vitto, Juan P. Valencia, and James A. Radosevich2 Mitochondria in Focus: Targeting the Cell-Death Mechanism 13Humberto De Vitto, Roberta Palorini, Giuseppina Votta, and Ferdinando Chiaradonna3 Microbial Programmed Cell Death 49Neal D. Hammer4 Autophagy 71Mollie K. Rojas, Juel Chowdhury, Khatja Batool, Zane Deliu, and Abdallah Oweidi5 Cell Injury, Adaptation, and Necrosis 83Sarah G. Fitzpatrick and Sara C. Gordon6 Necroptosis 99Ben A. Croker, James A. Rickard, Inbar Shlomovitz, Arshed Al-Obeidi, Akshay A. D’Cruz, and Motti Gerlic7 Ferroptosis 127Ebru Esin Yoruker and Ugur Gezer8 Anoikis Regulation: Complexities, Distinctions, and Cell Differentiation 145Marco Beauséjour, Ariane Boutin, and Pierre H. Vachon9 Cornification 183Leopold Eckhart10 Excitotoxicity 197Julie Alagha, Sulaiman Alshaar, and Zane Deliu11 Molecular Mechanisms Regulating Wallerian Degeneration 205Mohammad Tauseef and Madeeha Aqil12 Pyronecrosis 225Maryam Khalili and James A. Radosevich13 Phenoptosis: Programmed Death of an Organism 237M.V. Skulachev and V.P. Skulachev14 Molecular Mechanisms Underlying Oxytosis 289Amalia M. Dolga, Sina Oppermann, Maren Richter, Birgit Honrath, Sandra Neitemeier, Anja Jelinek, Goutham Ganjam, and Carsten Culmsee15 Pyroptosis 317Kate E. Lawlor, Stephanie Conos, and James E. Vince16 Paraptosis 343Maryam Khalili and James A. Radosevich17 Hematopoiesis and Eryptosis 367Mollie K. Rojas, Chintan C. Gandhi, and Lawrence E. FeldmanVolume 218 Cyclophilin D-Dependent Necrosis 375Jatin Mehta and Chandi Charan Mandal19 Role of Phospholipases in Cell Death 395Manikanda Raja, Juel Chowdhury, and James A. Radosevich20 TRIAD (Transcriptional Repression-Induced Atypical Death) 411Takuya Tamura and Hitoshi Okazawa21 Alkylating-Agent Cytotoxicity Associated with O6-Methylguanine 427Latha M. Malaiyandi, Lawrence A. Potempa, Nicholas Marschalk, Paiboon Jungsuwadee, and Kirk E. Dineley22 Entosis 463Jamuna A. Bai and Ravishankar Rai V.23 Mitotic Catastrophe 475Raquel De Souza, Lais Costa Ayub, and Kenneth Yip24 NETosis and ETosis: Incompletely Understood Types of Granulocyte Death and their Proposed Adaptive Benefits and Costs 511Marko Radic25 Parthanatos: Poly ADP Ribose Polymerase (PARP)-Mediated Cell Death 535Amos Fatokun26 Methuosis: Drinking to Death 559Madeeha Aqil27 Oncosis 567Priya Weerasinghe, Sarathi Hallock, Robert Brown, and L. Maximilian Buja28 Autoschizis: A Mode of Cell Death of Cancer Cells Induced by a Prooxidant Treatment In Vitro and In Vivo 583J. Gilloteaux, J.M. Jamison, D. Arnold, and J.L. Summers29 Programmed Death 1 (PD1)-Mediated T-Cell Apoptosis and Cancer Immunotherapy 695Chandi Charan Mandal, Jatin Mehta, and Vijay K. Prajapati

About the Editor JAMES A. RADOSEVICH, PH. D. is a Professor and Staff Research Scientist at the University of Illinois, Dental College and Cancer Center/VA, Chicago Health Care System. He is also an Affiliate Professor at Roosevelt University, College of Pharmacy, Department of Biopharmaceutical Sciences, USA.

Select Guide Rating

• List of Contributors ixVolume 11 General View of the Cytoplasmic and Nuclear Features of Apoptosis 1Humberto De Vitto, Juan P. Valencia, and James A. Radosevich2 Mitochondria in Focus: Targeting the Cell-Death Mechanism 13Humberto De Vitto, Roberta Palorini, Giuseppina Votta, and Ferdinando Chiaradonna3 Microbial Programmed Cell Death 49Neal D. Hammer4 Autophagy 71Mollie K. Rojas, Juel Chowdhury, Khatja Batool, Zane Deliu, and Abdallah Oweidi5 Cell Injury, Adaptation, and Necrosis 83Sarah G. Fitzpatrick and Sara C. Gordon6 Necroptosis 99Ben A. Croker, James A. Rickard, Inbar Shlomovitz, Arshed Al-Obeidi, Akshay A. D’Cruz, and Motti Gerlic7 Ferroptosis 127Ebru Esin Yoruker and Ugur Gezer8 Anoikis Regulation: Complexities, Distinctions, and Cell Differentiation 145Marco Beauséjour, Ariane Boutin, and Pierre H. Vachon9 Cornification 183Leopold Eckhart10 Excitotoxicity 197Julie Alagha, Sulaiman Alshaar, and Zane Deliu11 Molecular Mechanisms Regulating Wallerian Degeneration 205Mohammad Tauseef and Madeeha Aqil12 Pyronecrosis 225Maryam Khalili and James A. Radosevich13 Phenoptosis: Programmed Death of an Organism 237M.V. Skulachev and V.P. Skulachev14 Molecular Mechanisms Underlying Oxytosis 289Amalia M. Dolga, Sina Oppermann, Maren Richter, Birgit Honrath, Sandra Neitemeier, Anja Jelinek, Goutham Ganjam, and Carsten Culmsee15 Pyroptosis 317Kate E. Lawlor, Stephanie Conos, and James E. Vince16 Paraptosis 343Maryam Khalili and James A. Radosevich17 Hematopoiesis and Eryptosis 367Mollie K. Rojas, Chintan C. Gandhi, and Lawrence E. FeldmanVolume 218 Cyclophilin D-Dependent Necrosis 375Jatin Mehta and Chandi Charan Mandal19 Role of Phospholipases in Cell Death 395Manikanda Raja, Juel Chowdhury, and James A. Radosevich20 TRIAD (Transcriptional Repression-Induced Atypical Death) 411Takuya Tamura and Hitoshi Okazawa21 Alkylating-Agent Cytotoxicity Associated with O6-Methylguanine 427Latha M. Malaiyandi, Lawrence A. Potempa, Nicholas Marschalk, Paiboon Jungsuwadee, and Kirk E. Dineley22 Entosis 463Jamuna A. Bai and Ravishankar Rai V.23 Mitotic Catastrophe 475Raquel De Souza, Lais Costa Ayub, and Kenneth Yip24 NETosis and ETosis: Incompletely Understood Types of Granulocyte Death and their Proposed Adaptive Benefits and Costs 511Marko Radic25 Parthanatos: Poly ADP Ribose Polymerase (PARP)-Mediated Cell Death 535Amos Fatokun26 Methuosis: Drinking to Death 559Madeeha Aqil27 Oncosis 567Priya Weerasinghe, Sarathi Hallock, Robert Brown, and L. Maximilian Buja28 Autoschizis: A Mode of Cell Death of Cancer Cells Induced by a Prooxidant Treatment In Vitro and In Vivo 583J. Gilloteaux, J.M. Jamison, D. Arnold, and J.L. Summers29 Programmed Death 1 (PD1)-Mediated T-Cell Apoptosis and Cancer Immunotherapy 695Chandi Charan Mandal, Jatin Mehta, and Vijay K. Prajapati

About the Editor JAMES A. RADOSEVICH, PH. D. is a Professor and Staff Research Scientist at the University of Illinois, Dental College and Cancer Center/VA, Chicago Health Care System. He is also an Affiliate Professor at Roosevelt University, College of Pharmacy, Department of Biopharmaceutical Sciences, USA.

Select Guide Rating

• List of Contributors ixVolume 11 General View of the Cytoplasmic and Nuclear Features of Apoptosis 1Humberto De Vitto, Juan P. Valencia, and James A. Radosevich2 Mitochondria in Focus: Targeting the Cell-Death Mechanism 13Humberto De Vitto, Roberta Palorini, Giuseppina Votta, and Ferdinando Chiaradonna3 Microbial Programmed Cell Death 49Neal D. Hammer4 Autophagy 71Mollie K. Rojas, Juel Chowdhury, Khatja Batool, Zane Deliu, and Abdallah Oweidi5 Cell Injury, Adaptation, and Necrosis 83Sarah G. Fitzpatrick and Sara C. Gordon6 Necroptosis 99Ben A. Croker, James A. Rickard, Inbar Shlomovitz, Arshed Al-Obeidi, Akshay A. D’Cruz, and Motti Gerlic7 Ferroptosis 127Ebru Esin Yoruker and Ugur Gezer8 Anoikis Regulation: Complexities, Distinctions, and Cell Differentiation 145Marco Beauséjour, Ariane Boutin, and Pierre H. Vachon9 Cornification 183Leopold Eckhart10 Excitotoxicity 197Julie Alagha, Sulaiman Alshaar, and Zane Deliu11 Molecular Mechanisms Regulating Wallerian Degeneration 205Mohammad Tauseef and Madeeha Aqil12 Pyronecrosis 225Maryam Khalili and James A. Radosevich13 Phenoptosis: Programmed Death of an Organism 237M.V. Skulachev and V.P. Skulachev14 Molecular Mechanisms Underlying Oxytosis 289Amalia M. Dolga, Sina Oppermann, Maren Richter, Birgit Honrath, Sandra Neitemeier, Anja Jelinek, Goutham Ganjam, and Carsten Culmsee15 Pyroptosis 317Kate E. Lawlor, Stephanie Conos, and James E. Vince16 Paraptosis 343Maryam Khalili and James A. Radosevich17 Hematopoiesis and Eryptosis 367Mollie K. Rojas, Chintan C. Gandhi, and Lawrence E. FeldmanVolume 218 Cyclophilin D-Dependent Necrosis 375Jatin Mehta and Chandi Charan Mandal19 Role of Phospholipases in Cell Death 395Manikanda Raja, Juel Chowdhury, and James A. Radosevich20 TRIAD (Transcriptional Repression-Induced Atypical Death) 411Takuya Tamura and Hitoshi Okazawa21 Alkylating-Agent Cytotoxicity Associated with O6-Methylguanine 427Latha M. Malaiyandi, Lawrence A. Potempa, Nicholas Marschalk, Paiboon Jungsuwadee, and Kirk E. Dineley22 Entosis 463Jamuna A. Bai and Ravishankar Rai V.23 Mitotic Catastrophe 475Raquel De Souza, Lais Costa Ayub, and Kenneth Yip24 NETosis and ETosis: Incompletely Understood Types of Granulocyte Death and their Proposed Adaptive Benefits and Costs 511Marko Radic25 Parthanatos: Poly ADP Ribose Polymerase (PARP)-Mediated Cell Death 535Amos Fatokun26 Methuosis: Drinking to Death 559Madeeha Aqil27 Oncosis 567Priya Weerasinghe, Sarathi Hallock, Robert Brown, and L. Maximilian Buja28 Autoschizis: A Mode of Cell Death of Cancer Cells Induced by a Prooxidant Treatment In Vitro and In Vivo 583J. Gilloteaux, J.M. Jamison, D. Arnold, and J.L. Summers29 Programmed Death 1 (PD1)-Mediated T-Cell Apoptosis and Cancer Immunotherapy 695Chandi Charan Mandal, Jatin Mehta, and Vijay K. Prajapati