About the editorProf. J. Enrique Domínguez-Muñoz graduated in medicine from the University of Alcalá de Henares in Madrid, and got his PhD at the same University in 1990. In 1998, he became Director of the Department of Gastroenterology and Hepatology at the University Hospital of Santiago de Compostela, Spain. He is also Professor of Medicine at the University of Santiago de Compostela and permanent member of the Royal Academy of Medicine of Galicia. He has published more than 300 papers in peer reviewed journals, and has edited 12 books. He has been elected President of the European Pancreatic Club for 2024.

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• Contributors xxxiiiForeword xlviPreface xlviiDedication xlviiiSection I Acute Pancreatitis 11 Acute Pancreatitis: An Overview 3Jodie A. Barkin and Jamie S. Barkin2 How to Deal with the Etiological Diagnosis of Acute Pancreatitis in Clinical Practice? 17Soumya Jagannath and Pramod Kumar Garg3 Definition of Complications and Severity of Acute Pancreatitis for Clinical Practice 25David X. Jin, Peter A. Banks, and Julia McNabb-Baltar4 Early Prediction of Severity in Acute Pancreatitis: What can be Done in Clinical Practice? 31Peter J. Lee and Georgios I. Papachristou5 Role of CT Scan in Acute Pancreatitis: When is it Indicated and What Information can be Obtained? 40Elham Afghani, Mahya Faghih, and Vikesh K. Singh6 Role of MRI in Acute Pancreatitis: When is it Indicated and What Information can be Obtained? 47Fatih Akisik7 Treatment of Acute Pancreatitis in The Emergency Room: What Should be Done During the First Hours of Disease? 53Thiruvengadam Muniraj and Santhi Swaroop Vege8 Acute Pancreatitis: A Practical Guideline for the Monitoring and Treatment of Systemic Complications 59Enrique de Madaria and Felix Zubia-Olaskoaga9 Guidelines for the Treatment of Pain in Acute Pancreatitis 66László Czakó10 Nutrition in the Acute Phase of Pancreatitis: Why, When, How and How Long? 72Angela Pham and Chris E. Forsmark11 Oral Refeeding in Acute Pancreatitis: When and How Should it be Restarted? 78José Lariño-Noia and Daniel de la Iglesia-García12 Pharmacological Therapy for Acute Pancreatitis: Any Light at the End of the Tunnel? 83Rajarshi Mukherjee, Muhammad Awais, Wenhao Cai, Wei Huang, Peter Szatmary, and Robert Sutton13 Indication and Optimal Timing of ERCP in Acute Pancreatitis 95Theodor Voiosu, Ivo Boškoski, and Guido Costamagna14 How to Deal with Infected Pancreatic Necrosis? 100J. Enrique Domínguez-Muñoz15 Minimally Invasive Surgical Necrosectomy in Clinical Practice: Indications, Technical Issues, and Optimal Timing 105Patricia Sánchez-Velázquez, Fernando Burdío, and Ignasi Poves†16 Endoscopic Necrosectomy in Clinical Practice: Indications, Technical Issues and Optimal Timing 113Jodie A. Barkin and Andres Gelrud17 Management of Acute Pancreatic Pseudocyst: When to Observe, When and How to Drain? 120Muhammad F. Dawwas and Kofi W. Oppong18 The Disconnected Main Pancreatic Duct Syndrome: How to Proceed in Clinical Practice? 126Mario Peláez-Luna, Andrea Soriano-Ríos, and Luis Uscanga-Dominguez19 Vasculature Complications in Pancreatitis: How to Deal with Them? 132Daniel G. McCall and Timothy B. Gardner20 Acute Relapsing Pancreatitis: What can be Done to Prevent Relapses? 141Jorge D. Machicado and Dhiraj Yadav21 Diagnosis and Therapeutic Approach to Pancreatic Exocrine Insufficiency after Acute Pancreatitis 151Hester C. Timmerhuis, Christa J. Sperna Weiland, and Hjalmar C. van Santvoort22 Asymptomatic Chronic Elevation of Serum Pancreatic Enzymes: How to Deal with It? 158Giuseppe Vanella, Paolo Giorgio Arcidiacono, and Gabriele CapursoSection II Chronic Pancreatitis 16923 Definition and Etiology of Chronic Pancreatitis: What is Relevant for Clinical Practice? 171David C. Whitcomb24 Epidemiology of Chronic Pancreatitis: An Infrequent Disease or an Infrequently Diagnosed Disease? 180Philippe Lévy and Vinciane Rebours25 Alcoholic Chronic Pancreatitis and the Impact of Alcohol and Smoking Cessation in Chronic Pancreatitis 185Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte26 What is Relevant on Genetics in Chronic Pancreatitis for Clinical Practice? What Genes and When to Evaluate Them? 193Jonas Rosendahl27 Pancreas Divisum and Other Potential Obstructive Causes of Chronic Pancreatitis: When and How to Treat Them? 198Matthew J. DiMagno and Erik-Jan Wamsteker28 What to do in Clinical Practice Before Defining a Chronic Pancreatitis as Idiopathic? A Practical Protocol 208Felix Lämmerhirt, Frank Ulrich Weiss, and Markus M. Lerch29 Computed Tomography for the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 218Roberto García-Figueiras, Sandra Baleato-González, and Gonzalo Tardáguila de la Fuente30 Role of MRI and MRCP in the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 227Jordan K. Swensson and Temel Tirkes31 Role of Endoscopic Ultrasound and Associated Methods (Elastography, Contrast Enhancement) in the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 233Julio Iglesias-Garcia32 Endoscopic Pancreatic Function Test for the Functional Diagnosis of Chronic Pancreatitis: Indications and Practical Protocol 243Luis F. Lara and Darwin L. Conwell33 Role of Pancreatic Function Tests for the Diagnosis of Chronic Pancreatitis: Which Tests and How Should they be Performed in Clinical Practice? 250J. Enrique Domínguez-Muñoz34 Follow-up of Patients with Chronic Pancreatitis in Clinical Practice: How and What for? 255Antonio Mendoza-Ladd, Luis F. Lara, and Darwin L. Conwell35 Quality of Life in Chronic Pancreatitis 265Colin D. Johnson36 Medical Treatment of Pain in Chronic Pancreatitis: Guidelines for Clinical Practice 273Asbjørn Mohr Drewes, Louise Kuhlman, Trine Andresen, and Søren Schou Olesen37 Endoscopic Treatment of Pain in Chronic Pancreatitis: Indications, Optimal Timing, and Technical Aspects 283Pauline M. C. Stassen, Pieter J. F. de Jonge, Jan-Werner Poley, Djuna L. Cahen, and Marco .J. Bruno38 Diagnosis and Management of Pancreatic Exocrine Insufficiency in Chronic Pancreatitis: A Practical Protocol 292J. Enrique Domínguez-Muñoz39 Surgical Treatment of Pain in Chronic Pancreatitis: Indications, Optimal Timing and Technical Approaches 301Benjamin P.T. Loveday and John A. Windsor40 Management of Chronic Pancreatic Pseudocyst: When to Observe, When and How to Drain? 314Shyam Varadarajulu41 Vascular Complications in Chronic Pancreatitis 322Anil K. Agarwal, Raja Kalayarasan, and Amit Javed42 Surgical Therapy of Local Complications of Chronic Pancreatitis: Indications, Technical Approaches, and Optimal Timing 333Ricardo Arvizu Castillo, Elena Muñoz-Forner, and Luis Sabater43 Endoscopic Treatment of Complications of Chronic Pancreatitis other than Pseudocyst 342Jahangeer Basha, Rupjyoti Talukdar, and D. Nageshwar ReddySection III Autoimmune Pancreatitis 34744 Autoimmune Pancreatitis: Definition, Clinical Presentation, and Classification 349Miroslav Vujasinovic and J. -Matthias Löhr45 Diagnosis of Autoimmune Pancreatitis: A Protocol for Clinical Practice 356Nicolò de Pretis, Antonio Amodio, and Luca Frulloni46 Treatment and Follow-up of Autoimmune Pancreatitis in Clinical Practice 360Sushil Kumar Garg and Suresh T. ChariSection IV Cystic Fibrosis (CFTR)-associated Pancreatic Disease 36947 CFTR-associated Pancreatic Disease: Genotype–Phenotype Correlations and Impact of CFTR-modifying Therapy 371Aimee Joy Wiseman and Chee Y. Ooi48 Nutritional Therapy, Pancreatic Exocrine Insufficiency, and Pancreatic Enzyme Replacement Therapy in Cystic Fibrosis: a Protocol for Clinical Practice 379Jefferson N. Brownell, Laura Padula, Elizabeth Reid, Virginia A. Stallings, and Asim MaqboolSection V Pancreatic Cancer 38949 Epidemiological Impact of Pancreatic Cancer 391Patrick Maisonneuve50 Molecular and Genetic Basis of Pancreatic Carcinogenesis: Which Concepts are Clinically Relevant? 404Ihsan Ekin Demir, Carmen Mota Reyes, Elke Demir, and Helmut Friess51 New-onset Diabetes as a Harbinger of Pancreatic Cancer: is Early Diagnosis Possible? 409Dana K. Andersen, Suresh T. Chari, Eithne Costello, Tatjana Crnogorac-Jurcevic, Phil A. Hart, Anirban Maitra, and Stephen J. Pandol52 Pancreatic Cancer Screening: Target Populations, Methods, and Protocols for Clinical Practice 418Christopher Paiji, Anne Marie Lennon, and Elham Afghani53 Clinical Usefulness of Biological Markers in Pancreatic Cancer 425David Anz, Ignazio Piseddu, Marlies Köpke, Ujjwal M. Mahajan, and Julia Mayerle54 Staging Classification and Stratification of Pancreatic Cancer for Clinical Practice 433Akhil Chawla and Andrew J. Aguirre55 Imaging Diagnosis and Staging of Pancreatic Cancer: Which Methods are Essential and What Information Should they Provide? 443Megan H. Lee and Elliot K. Fishman56 The Role of Endoscopic Ultrasound and Associated Methods (Elastography, Contrast Enhancement) in the Diagnosis and Assessment of Resectability of Pancreatic Cancer 449Marc. Giovannini57 EUS-Guided FNA/FNB for Pancreatic Solid Lesions: When is it Indicated and What is the Optimal Technical Approach? 460Mihai Rimbaș, Gianenrico Rizzatti, and Alberto Larghi58 Surgical Treatment of Resectable Pancreatic Cancer: What is the Optimal Strategy? 472Jan G. D’Haese, Bernhard W. Renz, and Jens Werner59 Complications After Pancreatic Surgery: How to Deal with Them? 477Tommaso Giuliani, Giovanni Marchegiani, Giuseppe Malleo, and Claudio Bassi60 Neoadjuvant Treatment of Pancreatic Cancer: When and How? 488Marta Sandini, Thilo Hackert, Ulla Klaiber, Markus W. Büchler, and John P. Neoptolemos61 Adjuvant Therapy in Pancreatic Cancer: Options, Safety, and Outcomes 501Jean-Luc Van Laethem62 Management of Pain in Pancreatic Cancer: An Algorithm for Clinical Routine 506J. Enrique Domínguez-Muñoz63 EUS-guided Celiac Plexus Neurolysis for Pain in Pancreatic Cancer: When and How? 514Jonathan M. Wyse and Anand V. Sahai64 The Role of Endoscopy in the Management of Unresectable Pancreatic Cancer 520Jaimin P. Amin, Ajaypal Singh, and Irving Waxman65 Chemotherapy for Nonresectable Pancreatic Cancer 530Raquel Fuentes, Juan José Serrano, Mercedes Rodríguez, and Alfredo Carrato66 Diagnosis and Management of Pancreatic Exocrine Insufficiency in Pancreatic Cancer 538Sarah Powell-Brett and Keith J. Roberts67 Nutrition and Pancreatic Cancer 548Mary Phillips and Oonagh Griffin68 Present and Future of Local Therapies for Unresectable Pancreatic Cancer 555Sabrina Gloria Giulia Testoni, Gemma Rossi, Livia Archibugi, and Paolo Giorgio Arcidiacono69 New Pharmacological Approaches for Pancreatic Cancer Therapy: A Light at the End of the Tunnel? 564Vineet K. Gupta, Sulagna Banerjee, and Ashok K. SalujaSection VI Cystic Tumors of the Pancreas 57370 Histological Classification of Pancreatic Cystic Neoplasms 575Giuseppe Zamboni and Anna Pesci71 Role of Endoscopic Ultrasound and Endoscopic Ultrasound-associated Techniques in the Diagnosis and Differential Diagnosis of Pancreatic Cystic Tumors 584María-Victoria Alvarez-Sánchez and Bertrand Napoléon72 The Role of Multidetector CT, MRI and MRCP in the Diagnosis and Differential Diagnosis of Pancreatic Cystic Neoplasms 593Megan H. Lee and Elliot K. Fishman73 Intraductal Papillary Mucinous Neoplasm: When to Observe, When to Operate, and Optimal Surgical Approach 599Zhi Ven Fong and Carlos Fernandez-del Castillo74 Cystic Tumors Other than IPMN: When to Observe, When to Operate, and Optimal Surgical Approach 608John W. Kunstman, and James J. Farrell75 Pancreatic Cystic Tumors: any Role for Local Therapies? 624Julio Iglesias-GarciaSection VII Neuroendocrine and Other Tumors of the Pancreas 63176 Diagnosis and Treatment of Pancreatic Neuroendocrine Tumors: How to Deal with them in Clinical Practice? 633Francesca Muffatti, Stefano Partelli, Valentina Andreasi, and Massimo Falconi77 Other less Frequent Pancreatic Tumors: What Should be Known about Clinical Features, Diagnosis and Treatment? 641Rossana Percario, Paolo Panaccio, Fabio F. di Mola, Pierluigi Di Sebastiano, and Tommaso GrottolaSection VIII Functional Alterations of the Pancreas in Other Clinical Situations 65178 Diagnosis and Therapy of Exocrine Pancreatic Insufficiency after Gastric and Pancreatic Surgery 653Raffaele Pezzilli79 Pancreatic Exocrine Insufficiency in Type 1 and Type 2 Diabetes Mellitus: Lessons from Pancreatologists toDiabetologists 662Philip D. Hardt                                   80 Diabetes Mellitus Related to Diseases of the Exocrine Pancreas (Pancreatogenic Diabetes): Diagnosis and Treatment 668David A. Bradley and Phil A. HartIndex 679

About the editorProf. J. Enrique Domínguez-Muñoz graduated in medicine from the University of Alcalá de Henares in Madrid, and got his PhD at the same University in 1990. In 1998, he became Director of the Department of Gastroenterology and Hepatology at the University Hospital of Santiago de Compostela, Spain. He is also Professor of Medicine at the University of Santiago de Compostela and permanent member of the Royal Academy of Medicine of Galicia. He has published more than 300 papers in peer reviewed journals, and has edited 12 books. He has been elected President of the European Pancreatic Club for 2024.

Select Guide Rating

• Contributors xxxiiiForeword xlviPreface xlviiDedication xlviiiSection I Acute Pancreatitis 11 Acute Pancreatitis: An Overview 3Jodie A. Barkin and Jamie S. Barkin2 How to Deal with the Etiological Diagnosis of Acute Pancreatitis in Clinical Practice? 17Soumya Jagannath and Pramod Kumar Garg3 Definition of Complications and Severity of Acute Pancreatitis for Clinical Practice 25David X. Jin, Peter A. Banks, and Julia McNabb-Baltar4 Early Prediction of Severity in Acute Pancreatitis: What can be Done in Clinical Practice? 31Peter J. Lee and Georgios I. Papachristou5 Role of CT Scan in Acute Pancreatitis: When is it Indicated and What Information can be Obtained? 40Elham Afghani, Mahya Faghih, and Vikesh K. Singh6 Role of MRI in Acute Pancreatitis: When is it Indicated and What Information can be Obtained? 47Fatih Akisik7 Treatment of Acute Pancreatitis in The Emergency Room: What Should be Done During the First Hours of Disease? 53Thiruvengadam Muniraj and Santhi Swaroop Vege8 Acute Pancreatitis: A Practical Guideline for the Monitoring and Treatment of Systemic Complications 59Enrique de Madaria and Felix Zubia-Olaskoaga9 Guidelines for the Treatment of Pain in Acute Pancreatitis 66László Czakó10 Nutrition in the Acute Phase of Pancreatitis: Why, When, How and How Long? 72Angela Pham and Chris E. Forsmark11 Oral Refeeding in Acute Pancreatitis: When and How Should it be Restarted? 78José Lariño-Noia and Daniel de la Iglesia-García12 Pharmacological Therapy for Acute Pancreatitis: Any Light at the End of the Tunnel? 83Rajarshi Mukherjee, Muhammad Awais, Wenhao Cai, Wei Huang, Peter Szatmary, and Robert Sutton13 Indication and Optimal Timing of ERCP in Acute Pancreatitis 95Theodor Voiosu, Ivo Boškoski, and Guido Costamagna14 How to Deal with Infected Pancreatic Necrosis? 100J. Enrique Domínguez-Muñoz15 Minimally Invasive Surgical Necrosectomy in Clinical Practice: Indications, Technical Issues, and Optimal Timing 105Patricia Sánchez-Velázquez, Fernando Burdío, and Ignasi Poves†16 Endoscopic Necrosectomy in Clinical Practice: Indications, Technical Issues and Optimal Timing 113Jodie A. Barkin and Andres Gelrud17 Management of Acute Pancreatic Pseudocyst: When to Observe, When and How to Drain? 120Muhammad F. Dawwas and Kofi W. Oppong18 The Disconnected Main Pancreatic Duct Syndrome: How to Proceed in Clinical Practice? 126Mario Peláez-Luna, Andrea Soriano-Ríos, and Luis Uscanga-Dominguez19 Vasculature Complications in Pancreatitis: How to Deal with Them? 132Daniel G. McCall and Timothy B. Gardner20 Acute Relapsing Pancreatitis: What can be Done to Prevent Relapses? 141Jorge D. Machicado and Dhiraj Yadav21 Diagnosis and Therapeutic Approach to Pancreatic Exocrine Insufficiency after Acute Pancreatitis 151Hester C. Timmerhuis, Christa J. Sperna Weiland, and Hjalmar C. van Santvoort22 Asymptomatic Chronic Elevation of Serum Pancreatic Enzymes: How to Deal with It? 158Giuseppe Vanella, Paolo Giorgio Arcidiacono, and Gabriele CapursoSection II Chronic Pancreatitis 16923 Definition and Etiology of Chronic Pancreatitis: What is Relevant for Clinical Practice? 171David C. Whitcomb24 Epidemiology of Chronic Pancreatitis: An Infrequent Disease or an Infrequently Diagnosed Disease? 180Philippe Lévy and Vinciane Rebours25 Alcoholic Chronic Pancreatitis and the Impact of Alcohol and Smoking Cessation in Chronic Pancreatitis 185Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte26 What is Relevant on Genetics in Chronic Pancreatitis for Clinical Practice? What Genes and When to Evaluate Them? 193Jonas Rosendahl27 Pancreas Divisum and Other Potential Obstructive Causes of Chronic Pancreatitis: When and How to Treat Them? 198Matthew J. DiMagno and Erik-Jan Wamsteker28 What to do in Clinical Practice Before Defining a Chronic Pancreatitis as Idiopathic? A Practical Protocol 208Felix Lämmerhirt, Frank Ulrich Weiss, and Markus M. Lerch29 Computed Tomography for the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 218Roberto García-Figueiras, Sandra Baleato-González, and Gonzalo Tardáguila de la Fuente30 Role of MRI and MRCP in the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 227Jordan K. Swensson and Temel Tirkes31 Role of Endoscopic Ultrasound and Associated Methods (Elastography, Contrast Enhancement) in the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 233Julio Iglesias-Garcia32 Endoscopic Pancreatic Function Test for the Functional Diagnosis of Chronic Pancreatitis: Indications and Practical Protocol 243Luis F. Lara and Darwin L. Conwell33 Role of Pancreatic Function Tests for the Diagnosis of Chronic Pancreatitis: Which Tests and How Should they be Performed in Clinical Practice? 250J. Enrique Domínguez-Muñoz34 Follow-up of Patients with Chronic Pancreatitis in Clinical Practice: How and What for? 255Antonio Mendoza-Ladd, Luis F. Lara, and Darwin L. Conwell35 Quality of Life in Chronic Pancreatitis 265Colin D. Johnson36 Medical Treatment of Pain in Chronic Pancreatitis: Guidelines for Clinical Practice 273Asbjørn Mohr Drewes, Louise Kuhlman, Trine Andresen, and Søren Schou Olesen37 Endoscopic Treatment of Pain in Chronic Pancreatitis: Indications, Optimal Timing, and Technical Aspects 283Pauline M. C. Stassen, Pieter J. F. de Jonge, Jan-Werner Poley, Djuna L. Cahen, and Marco .J. Bruno38 Diagnosis and Management of Pancreatic Exocrine Insufficiency in Chronic Pancreatitis: A Practical Protocol 292J. Enrique Domínguez-Muñoz39 Surgical Treatment of Pain in Chronic Pancreatitis: Indications, Optimal Timing and Technical Approaches 301Benjamin P.T. Loveday and John A. Windsor40 Management of Chronic Pancreatic Pseudocyst: When to Observe, When and How to Drain? 314Shyam Varadarajulu41 Vascular Complications in Chronic Pancreatitis 322Anil K. Agarwal, Raja Kalayarasan, and Amit Javed42 Surgical Therapy of Local Complications of Chronic Pancreatitis: Indications, Technical Approaches, and Optimal Timing 333Ricardo Arvizu Castillo, Elena Muñoz-Forner, and Luis Sabater43 Endoscopic Treatment of Complications of Chronic Pancreatitis other than Pseudocyst 342Jahangeer Basha, Rupjyoti Talukdar, and D. Nageshwar ReddySection III Autoimmune Pancreatitis 34744 Autoimmune Pancreatitis: Definition, Clinical Presentation, and Classification 349Miroslav Vujasinovic and J. -Matthias Löhr45 Diagnosis of Autoimmune Pancreatitis: A Protocol for Clinical Practice 356Nicolò de Pretis, Antonio Amodio, and Luca Frulloni46 Treatment and Follow-up of Autoimmune Pancreatitis in Clinical Practice 360Sushil Kumar Garg and Suresh T. ChariSection IV Cystic Fibrosis (CFTR)-associated Pancreatic Disease 36947 CFTR-associated Pancreatic Disease: Genotype–Phenotype Correlations and Impact of CFTR-modifying Therapy 371Aimee Joy Wiseman and Chee Y. Ooi48 Nutritional Therapy, Pancreatic Exocrine Insufficiency, and Pancreatic Enzyme Replacement Therapy in Cystic Fibrosis: a Protocol for Clinical Practice 379Jefferson N. Brownell, Laura Padula, Elizabeth Reid, Virginia A. Stallings, and Asim MaqboolSection V Pancreatic Cancer 38949 Epidemiological Impact of Pancreatic Cancer 391Patrick Maisonneuve50 Molecular and Genetic Basis of Pancreatic Carcinogenesis: Which Concepts are Clinically Relevant? 404Ihsan Ekin Demir, Carmen Mota Reyes, Elke Demir, and Helmut Friess51 New-onset Diabetes as a Harbinger of Pancreatic Cancer: is Early Diagnosis Possible? 409Dana K. Andersen, Suresh T. Chari, Eithne Costello, Tatjana Crnogorac-Jurcevic, Phil A. Hart, Anirban Maitra, and Stephen J. Pandol52 Pancreatic Cancer Screening: Target Populations, Methods, and Protocols for Clinical Practice 418Christopher Paiji, Anne Marie Lennon, and Elham Afghani53 Clinical Usefulness of Biological Markers in Pancreatic Cancer 425David Anz, Ignazio Piseddu, Marlies Köpke, Ujjwal M. Mahajan, and Julia Mayerle54 Staging Classification and Stratification of Pancreatic Cancer for Clinical Practice 433Akhil Chawla and Andrew J. Aguirre55 Imaging Diagnosis and Staging of Pancreatic Cancer: Which Methods are Essential and What Information Should they Provide? 443Megan H. Lee and Elliot K. Fishman56 The Role of Endoscopic Ultrasound and Associated Methods (Elastography, Contrast Enhancement) in the Diagnosis and Assessment of Resectability of Pancreatic Cancer 449Marc. Giovannini57 EUS-Guided FNA/FNB for Pancreatic Solid Lesions: When is it Indicated and What is the Optimal Technical Approach? 460Mihai Rimbaș, Gianenrico Rizzatti, and Alberto Larghi58 Surgical Treatment of Resectable Pancreatic Cancer: What is the Optimal Strategy? 472Jan G. D’Haese, Bernhard W. Renz, and Jens Werner59 Complications After Pancreatic Surgery: How to Deal with Them? 477Tommaso Giuliani, Giovanni Marchegiani, Giuseppe Malleo, and Claudio Bassi60 Neoadjuvant Treatment of Pancreatic Cancer: When and How? 488Marta Sandini, Thilo Hackert, Ulla Klaiber, Markus W. Büchler, and John P. Neoptolemos61 Adjuvant Therapy in Pancreatic Cancer: Options, Safety, and Outcomes 501Jean-Luc Van Laethem62 Management of Pain in Pancreatic Cancer: An Algorithm for Clinical Routine 506J. Enrique Domínguez-Muñoz63 EUS-guided Celiac Plexus Neurolysis for Pain in Pancreatic Cancer: When and How? 514Jonathan M. Wyse and Anand V. Sahai64 The Role of Endoscopy in the Management of Unresectable Pancreatic Cancer 520Jaimin P. Amin, Ajaypal Singh, and Irving Waxman65 Chemotherapy for Nonresectable Pancreatic Cancer 530Raquel Fuentes, Juan José Serrano, Mercedes Rodríguez, and Alfredo Carrato66 Diagnosis and Management of Pancreatic Exocrine Insufficiency in Pancreatic Cancer 538Sarah Powell-Brett and Keith J. Roberts67 Nutrition and Pancreatic Cancer 548Mary Phillips and Oonagh Griffin68 Present and Future of Local Therapies for Unresectable Pancreatic Cancer 555Sabrina Gloria Giulia Testoni, Gemma Rossi, Livia Archibugi, and Paolo Giorgio Arcidiacono69 New Pharmacological Approaches for Pancreatic Cancer Therapy: A Light at the End of the Tunnel? 564Vineet K. Gupta, Sulagna Banerjee, and Ashok K. SalujaSection VI Cystic Tumors of the Pancreas 57370 Histological Classification of Pancreatic Cystic Neoplasms 575Giuseppe Zamboni and Anna Pesci71 Role of Endoscopic Ultrasound and Endoscopic Ultrasound-associated Techniques in the Diagnosis and Differential Diagnosis of Pancreatic Cystic Tumors 584María-Victoria Alvarez-Sánchez and Bertrand Napoléon72 The Role of Multidetector CT, MRI and MRCP in the Diagnosis and Differential Diagnosis of Pancreatic Cystic Neoplasms 593Megan H. Lee and Elliot K. Fishman73 Intraductal Papillary Mucinous Neoplasm: When to Observe, When to Operate, and Optimal Surgical Approach 599Zhi Ven Fong and Carlos Fernandez-del Castillo74 Cystic Tumors Other than IPMN: When to Observe, When to Operate, and Optimal Surgical Approach 608John W. Kunstman, and James J. Farrell75 Pancreatic Cystic Tumors: any Role for Local Therapies? 624Julio Iglesias-GarciaSection VII Neuroendocrine and Other Tumors of the Pancreas 63176 Diagnosis and Treatment of Pancreatic Neuroendocrine Tumors: How to Deal with them in Clinical Practice? 633Francesca Muffatti, Stefano Partelli, Valentina Andreasi, and Massimo Falconi77 Other less Frequent Pancreatic Tumors: What Should be Known about Clinical Features, Diagnosis and Treatment? 641Rossana Percario, Paolo Panaccio, Fabio F. di Mola, Pierluigi Di Sebastiano, and Tommaso GrottolaSection VIII Functional Alterations of the Pancreas in Other Clinical Situations 65178 Diagnosis and Therapy of Exocrine Pancreatic Insufficiency after Gastric and Pancreatic Surgery 653Raffaele Pezzilli79 Pancreatic Exocrine Insufficiency in Type 1 and Type 2 Diabetes Mellitus: Lessons from Pancreatologists toDiabetologists 662Philip D. Hardt                                   80 Diabetes Mellitus Related to Diseases of the Exocrine Pancreas (Pancreatogenic Diabetes): Diagnosis and Treatment 668David A. Bradley and Phil A. HartIndex 679

About the editorProf. J. Enrique Domínguez-Muñoz graduated in medicine from the University of Alcalá de Henares in Madrid, and got his PhD at the same University in 1990. In 1998, he became Director of the Department of Gastroenterology and Hepatology at the University Hospital of Santiago de Compostela, Spain. He is also Professor of Medicine at the University of Santiago de Compostela and permanent member of the Royal Academy of Medicine of Galicia. He has published more than 300 papers in peer reviewed journals, and has edited 12 books. He has been elected President of the European Pancreatic Club for 2024.

Select Guide Rating

• Contributors xxxiiiForeword xlviPreface xlviiDedication xlviiiSection I Acute Pancreatitis 11 Acute Pancreatitis: An Overview 3Jodie A. Barkin and Jamie S. Barkin2 How to Deal with the Etiological Diagnosis of Acute Pancreatitis in Clinical Practice? 17Soumya Jagannath and Pramod Kumar Garg3 Definition of Complications and Severity of Acute Pancreatitis for Clinical Practice 25David X. Jin, Peter A. Banks, and Julia McNabb-Baltar4 Early Prediction of Severity in Acute Pancreatitis: What can be Done in Clinical Practice? 31Peter J. Lee and Georgios I. Papachristou5 Role of CT Scan in Acute Pancreatitis: When is it Indicated and What Information can be Obtained? 40Elham Afghani, Mahya Faghih, and Vikesh K. Singh6 Role of MRI in Acute Pancreatitis: When is it Indicated and What Information can be Obtained? 47Fatih Akisik7 Treatment of Acute Pancreatitis in The Emergency Room: What Should be Done During the First Hours of Disease? 53Thiruvengadam Muniraj and Santhi Swaroop Vege8 Acute Pancreatitis: A Practical Guideline for the Monitoring and Treatment of Systemic Complications 59Enrique de Madaria and Felix Zubia-Olaskoaga9 Guidelines for the Treatment of Pain in Acute Pancreatitis 66László Czakó10 Nutrition in the Acute Phase of Pancreatitis: Why, When, How and How Long? 72Angela Pham and Chris E. Forsmark11 Oral Refeeding in Acute Pancreatitis: When and How Should it be Restarted? 78José Lariño-Noia and Daniel de la Iglesia-García12 Pharmacological Therapy for Acute Pancreatitis: Any Light at the End of the Tunnel? 83Rajarshi Mukherjee, Muhammad Awais, Wenhao Cai, Wei Huang, Peter Szatmary, and Robert Sutton13 Indication and Optimal Timing of ERCP in Acute Pancreatitis 95Theodor Voiosu, Ivo Boškoski, and Guido Costamagna14 How to Deal with Infected Pancreatic Necrosis? 100J. Enrique Domínguez-Muñoz15 Minimally Invasive Surgical Necrosectomy in Clinical Practice: Indications, Technical Issues, and Optimal Timing 105Patricia Sánchez-Velázquez, Fernando Burdío, and Ignasi Poves†16 Endoscopic Necrosectomy in Clinical Practice: Indications, Technical Issues and Optimal Timing 113Jodie A. Barkin and Andres Gelrud17 Management of Acute Pancreatic Pseudocyst: When to Observe, When and How to Drain? 120Muhammad F. Dawwas and Kofi W. Oppong18 The Disconnected Main Pancreatic Duct Syndrome: How to Proceed in Clinical Practice? 126Mario Peláez-Luna, Andrea Soriano-Ríos, and Luis Uscanga-Dominguez19 Vasculature Complications in Pancreatitis: How to Deal with Them? 132Daniel G. McCall and Timothy B. Gardner20 Acute Relapsing Pancreatitis: What can be Done to Prevent Relapses? 141Jorge D. Machicado and Dhiraj Yadav21 Diagnosis and Therapeutic Approach to Pancreatic Exocrine Insufficiency after Acute Pancreatitis 151Hester C. Timmerhuis, Christa J. Sperna Weiland, and Hjalmar C. van Santvoort22 Asymptomatic Chronic Elevation of Serum Pancreatic Enzymes: How to Deal with It? 158Giuseppe Vanella, Paolo Giorgio Arcidiacono, and Gabriele CapursoSection II Chronic Pancreatitis 16923 Definition and Etiology of Chronic Pancreatitis: What is Relevant for Clinical Practice? 171David C. Whitcomb24 Epidemiology of Chronic Pancreatitis: An Infrequent Disease or an Infrequently Diagnosed Disease? 180Philippe Lévy and Vinciane Rebours25 Alcoholic Chronic Pancreatitis and the Impact of Alcohol and Smoking Cessation in Chronic Pancreatitis 185Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte26 What is Relevant on Genetics in Chronic Pancreatitis for Clinical Practice? What Genes and When to Evaluate Them? 193Jonas Rosendahl27 Pancreas Divisum and Other Potential Obstructive Causes of Chronic Pancreatitis: When and How to Treat Them? 198Matthew J. DiMagno and Erik-Jan Wamsteker28 What to do in Clinical Practice Before Defining a Chronic Pancreatitis as Idiopathic? A Practical Protocol 208Felix Lämmerhirt, Frank Ulrich Weiss, and Markus M. Lerch29 Computed Tomography for the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 218Roberto García-Figueiras, Sandra Baleato-González, and Gonzalo Tardáguila de la Fuente30 Role of MRI and MRCP in the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 227Jordan K. Swensson and Temel Tirkes31 Role of Endoscopic Ultrasound and Associated Methods (Elastography, Contrast Enhancement) in the Diagnosis, Evaluation of Severity, and Detection of Complications of Chronic Pancreatitis in Clinical Practice 233Julio Iglesias-Garcia32 Endoscopic Pancreatic Function Test for the Functional Diagnosis of Chronic Pancreatitis: Indications and Practical Protocol 243Luis F. Lara and Darwin L. Conwell33 Role of Pancreatic Function Tests for the Diagnosis of Chronic Pancreatitis: Which Tests and How Should they be Performed in Clinical Practice? 250J. Enrique Domínguez-Muñoz34 Follow-up of Patients with Chronic Pancreatitis in Clinical Practice: How and What for? 255Antonio Mendoza-Ladd, Luis F. Lara, and Darwin L. Conwell35 Quality of Life in Chronic Pancreatitis 265Colin D. Johnson36 Medical Treatment of Pain in Chronic Pancreatitis: Guidelines for Clinical Practice 273Asbjørn Mohr Drewes, Louise Kuhlman, Trine Andresen, and Søren Schou Olesen37 Endoscopic Treatment of Pain in Chronic Pancreatitis: Indications, Optimal Timing, and Technical Aspects 283Pauline M. C. Stassen, Pieter J. F. de Jonge, Jan-Werner Poley, Djuna L. Cahen, and Marco .J. Bruno38 Diagnosis and Management of Pancreatic Exocrine Insufficiency in Chronic Pancreatitis: A Practical Protocol 292J. Enrique Domínguez-Muñoz39 Surgical Treatment of Pain in Chronic Pancreatitis: Indications, Optimal Timing and Technical Approaches 301Benjamin P.T. Loveday and John A. Windsor40 Management of Chronic Pancreatic Pseudocyst: When to Observe, When and How to Drain? 314Shyam Varadarajulu41 Vascular Complications in Chronic Pancreatitis 322Anil K. Agarwal, Raja Kalayarasan, and Amit Javed42 Surgical Therapy of Local Complications of Chronic Pancreatitis: Indications, Technical Approaches, and Optimal Timing 333Ricardo Arvizu Castillo, Elena Muñoz-Forner, and Luis Sabater43 Endoscopic Treatment of Complications of Chronic Pancreatitis other than Pseudocyst 342Jahangeer Basha, Rupjyoti Talukdar, and D. Nageshwar ReddySection III Autoimmune Pancreatitis 34744 Autoimmune Pancreatitis: Definition, Clinical Presentation, and Classification 349Miroslav Vujasinovic and J. -Matthias Löhr45 Diagnosis of Autoimmune Pancreatitis: A Protocol for Clinical Practice 356Nicolò de Pretis, Antonio Amodio, and Luca Frulloni46 Treatment and Follow-up of Autoimmune Pancreatitis in Clinical Practice 360Sushil Kumar Garg and Suresh T. ChariSection IV Cystic Fibrosis (CFTR)-associated Pancreatic Disease 36947 CFTR-associated Pancreatic Disease: Genotype–Phenotype Correlations and Impact of CFTR-modifying Therapy 371Aimee Joy Wiseman and Chee Y. Ooi48 Nutritional Therapy, Pancreatic Exocrine Insufficiency, and Pancreatic Enzyme Replacement Therapy in Cystic Fibrosis: a Protocol for Clinical Practice 379Jefferson N. Brownell, Laura Padula, Elizabeth Reid, Virginia A. Stallings, and Asim MaqboolSection V Pancreatic Cancer 38949 Epidemiological Impact of Pancreatic Cancer 391Patrick Maisonneuve50 Molecular and Genetic Basis of Pancreatic Carcinogenesis: Which Concepts are Clinically Relevant? 404Ihsan Ekin Demir, Carmen Mota Reyes, Elke Demir, and Helmut Friess51 New-onset Diabetes as a Harbinger of Pancreatic Cancer: is Early Diagnosis Possible? 409Dana K. Andersen, Suresh T. Chari, Eithne Costello, Tatjana Crnogorac-Jurcevic, Phil A. Hart, Anirban Maitra, and Stephen J. Pandol52 Pancreatic Cancer Screening: Target Populations, Methods, and Protocols for Clinical Practice 418Christopher Paiji, Anne Marie Lennon, and Elham Afghani53 Clinical Usefulness of Biological Markers in Pancreatic Cancer 425David Anz, Ignazio Piseddu, Marlies Köpke, Ujjwal M. Mahajan, and Julia Mayerle54 Staging Classification and Stratification of Pancreatic Cancer for Clinical Practice 433Akhil Chawla and Andrew J. Aguirre55 Imaging Diagnosis and Staging of Pancreatic Cancer: Which Methods are Essential and What Information Should they Provide? 443Megan H. Lee and Elliot K. Fishman56 The Role of Endoscopic Ultrasound and Associated Methods (Elastography, Contrast Enhancement) in the Diagnosis and Assessment of Resectability of Pancreatic Cancer 449Marc. Giovannini57 EUS-Guided FNA/FNB for Pancreatic Solid Lesions: When is it Indicated and What is the Optimal Technical Approach? 460Mihai Rimbaș, Gianenrico Rizzatti, and Alberto Larghi58 Surgical Treatment of Resectable Pancreatic Cancer: What is the Optimal Strategy? 472Jan G. D’Haese, Bernhard W. Renz, and Jens Werner59 Complications After Pancreatic Surgery: How to Deal with Them? 477Tommaso Giuliani, Giovanni Marchegiani, Giuseppe Malleo, and Claudio Bassi60 Neoadjuvant Treatment of Pancreatic Cancer: When and How? 488Marta Sandini, Thilo Hackert, Ulla Klaiber, Markus W. Büchler, and John P. Neoptolemos61 Adjuvant Therapy in Pancreatic Cancer: Options, Safety, and Outcomes 501Jean-Luc Van Laethem62 Management of Pain in Pancreatic Cancer: An Algorithm for Clinical Routine 506J. Enrique Domínguez-Muñoz63 EUS-guided Celiac Plexus Neurolysis for Pain in Pancreatic Cancer: When and How? 514Jonathan M. Wyse and Anand V. Sahai64 The Role of Endoscopy in the Management of Unresectable Pancreatic Cancer 520Jaimin P. Amin, Ajaypal Singh, and Irving Waxman65 Chemotherapy for Nonresectable Pancreatic Cancer 530Raquel Fuentes, Juan José Serrano, Mercedes Rodríguez, and Alfredo Carrato66 Diagnosis and Management of Pancreatic Exocrine Insufficiency in Pancreatic Cancer 538Sarah Powell-Brett and Keith J. Roberts67 Nutrition and Pancreatic Cancer 548Mary Phillips and Oonagh Griffin68 Present and Future of Local Therapies for Unresectable Pancreatic Cancer 555Sabrina Gloria Giulia Testoni, Gemma Rossi, Livia Archibugi, and Paolo Giorgio Arcidiacono69 New Pharmacological Approaches for Pancreatic Cancer Therapy: A Light at the End of the Tunnel? 564Vineet K. Gupta, Sulagna Banerjee, and Ashok K. SalujaSection VI Cystic Tumors of the Pancreas 57370 Histological Classification of Pancreatic Cystic Neoplasms 575Giuseppe Zamboni and Anna Pesci71 Role of Endoscopic Ultrasound and Endoscopic Ultrasound-associated Techniques in the Diagnosis and Differential Diagnosis of Pancreatic Cystic Tumors 584María-Victoria Alvarez-Sánchez and Bertrand Napoléon72 The Role of Multidetector CT, MRI and MRCP in the Diagnosis and Differential Diagnosis of Pancreatic Cystic Neoplasms 593Megan H. Lee and Elliot K. Fishman73 Intraductal Papillary Mucinous Neoplasm: When to Observe, When to Operate, and Optimal Surgical Approach 599Zhi Ven Fong and Carlos Fernandez-del Castillo74 Cystic Tumors Other than IPMN: When to Observe, When to Operate, and Optimal Surgical Approach 608John W. Kunstman, and James J. Farrell75 Pancreatic Cystic Tumors: any Role for Local Therapies? 624Julio Iglesias-GarciaSection VII Neuroendocrine and Other Tumors of the Pancreas 63176 Diagnosis and Treatment of Pancreatic Neuroendocrine Tumors: How to Deal with them in Clinical Practice? 633Francesca Muffatti, Stefano Partelli, Valentina Andreasi, and Massimo Falconi77 Other less Frequent Pancreatic Tumors: What Should be Known about Clinical Features, Diagnosis and Treatment? 641Rossana Percario, Paolo Panaccio, Fabio F. di Mola, Pierluigi Di Sebastiano, and Tommaso GrottolaSection VIII Functional Alterations of the Pancreas in Other Clinical Situations 65178 Diagnosis and Therapy of Exocrine Pancreatic Insufficiency after Gastric and Pancreatic Surgery 653Raffaele Pezzilli79 Pancreatic Exocrine Insufficiency in Type 1 and Type 2 Diabetes Mellitus: Lessons from Pancreatologists toDiabetologists 662Philip D. Hardt                                   80 Diabetes Mellitus Related to Diseases of the Exocrine Pancreas (Pancreatogenic Diabetes): Diagnosis and Treatment 668David A. Bradley and Phil A. HartIndex 679