Stephen M. Roberts, PhD, is Professor and Program Director of the Center for Environmental and Human Toxicology at the University of Florida, Gainesville, FL.Robert C. James, PhD, is Senior Science Advisor, ToxStrategies, Boise, ID. Phillip L. Williams, PhD, is Dean and Professor Emeritus, College of Public Health, University of Georgia, Athens, GA.

• 1 General Principles of ToxicologyRobert C. James, Stephen M. Roberts, and Phillip L. Williams2 Xenobiotic Absorption, Distribution, Metabolism and ExcretionMichael R. Franklin3 ToxicokineticsRebecca A. Clewell and Harvey J. Clewell III4 Regulatory ToxicologyRaymond M. David5 Alternative Methods in Toxicity TestingLeona D. Scanlan, XuefeiCao, and Christopher D. Vulpe6 ComputationalToxicologyRichard S. Judson, David M. Reif, Keith A. Houck, Thomas B. Knudsen, Joshua Harrill, Katie Paul Friedman7 Hematotoxicity:Toxic Effects on the Hematopoietic SystemLila Ramaiah, Tara Arndt, and Michelle Cora8 Hepatotoxicity: Toxic Effects on the LiveRobert C. James and Stephen M. Roberts9 Nephrotoxicity: Toxic Effects on the KidneyLawrence H. Lash10 Neurotoxicology: Toxic Effects on the Nervous SystemW. Michael Caudle, Meghan Bucher, Alexandria C. White, and Gary W. Miller11 Dermal Toxicology: Toxic Effects on the SkinSailesh Konda and Howard I Maibach12 Pulmonotoxicity: Toxic Effects on the Respiratory SystemCuiqing Liu and Qinghua Sun13 Immunotoxicity: Toxic Effects on the Immune SystemEric S. Sobel and Stephen M. Roberts14 Reproductive and Developmental Toxicity: Toxic Effects on the Female and Male Reproductive Tracts and OffspringShuo Xiao, Krista Symosko, and Charles A. Easley IV15 Mutagenesis and Genetic ToxicologyMartha M. Moore, Meagan B. Myers and Robert H. Heflich16 Chemical CarcinogenesisJames E. Klaunig, Luma Melo, and Karen Tilmant17 Properties and Effects of MetalsDavid B. Mayfield, Lisa A. Bailey, Joel M. Cohen, and Barbara D. Beck18 PesticidesJanice Britt19 Properties and Toxicology of Organic Solvents and Solvent-Like ChemicalsChristopher M. Teaf and Michele M. Garber20 NanotoxicologyHongbo Ma and Stephen M. Roberts21 Insights into EpidemiologyJ. Fryzek, C. Frankenfeld, N. Movva, L. Bylsma, and J. Acquavella22 Occupational and Environmental HealthLaura Breeher, Fredric Gerr, and T. Renėe Anthony23 Human Health Risk AssessmentLeah D. Stuchal24 Ecological Risk AssessmentBrett Thomas25 The Dilemma of Selecting Safe Exposure ValuesRobert C. James, Phillip L. Williams,and Stephen M. Roberts

Stephen M. Roberts, PhD, is Professor and Program Director of the Center for Environmental and Human Toxicology at the University of Florida, Gainesville, FL.Robert C. James, PhD, is Senior Science Advisor, ToxStrategies, Boise, ID. Phillip L. Williams, PhD, is Dean and Professor Emeritus, College of Public Health, University of Georgia, Athens, GA.

• 1 General Principles of ToxicologyRobert C. James, Stephen M. Roberts, and Phillip L. Williams2 Xenobiotic Absorption, Distribution, Metabolism and ExcretionMichael R. Franklin3 ToxicokineticsRebecca A. Clewell and Harvey J. Clewell III4 Regulatory ToxicologyRaymond M. David5 Alternative Methods in Toxicity TestingLeona D. Scanlan, XuefeiCao, and Christopher D. Vulpe6 ComputationalToxicologyRichard S. Judson, David M. Reif, Keith A. Houck, Thomas B. Knudsen, Joshua Harrill, Katie Paul Friedman7 Hematotoxicity:Toxic Effects on the Hematopoietic SystemLila Ramaiah, Tara Arndt, and Michelle Cora8 Hepatotoxicity: Toxic Effects on the LiveRobert C. James and Stephen M. Roberts9 Nephrotoxicity: Toxic Effects on the KidneyLawrence H. Lash10 Neurotoxicology: Toxic Effects on the Nervous SystemW. Michael Caudle, Meghan Bucher, Alexandria C. White, and Gary W. Miller11 Dermal Toxicology: Toxic Effects on the SkinSailesh Konda and Howard I Maibach12 Pulmonotoxicity: Toxic Effects on the Respiratory SystemCuiqing Liu and Qinghua Sun13 Immunotoxicity: Toxic Effects on the Immune SystemEric S. Sobel and Stephen M. Roberts14 Reproductive and Developmental Toxicity: Toxic Effects on the Female and Male Reproductive Tracts and OffspringShuo Xiao, Krista Symosko, and Charles A. Easley IV15 Mutagenesis and Genetic ToxicologyMartha M. Moore, Meagan B. Myers and Robert H. Heflich16 Chemical CarcinogenesisJames E. Klaunig, Luma Melo, and Karen Tilmant17 Properties and Effects of MetalsDavid B. Mayfield, Lisa A. Bailey, Joel M. Cohen, and Barbara D. Beck18 PesticidesJanice Britt19 Properties and Toxicology of Organic Solvents and Solvent-Like ChemicalsChristopher M. Teaf and Michele M. Garber20 NanotoxicologyHongbo Ma and Stephen M. Roberts21 Insights into EpidemiologyJ. Fryzek, C. Frankenfeld, N. Movva, L. Bylsma, and J. Acquavella22 Occupational and Environmental HealthLaura Breeher, Fredric Gerr, and T. Renėe Anthony23 Human Health Risk AssessmentLeah D. Stuchal24 Ecological Risk AssessmentBrett Thomas25 The Dilemma of Selecting Safe Exposure ValuesRobert C. James, Phillip L. Williams,and Stephen M. Roberts

Stephen M. Roberts, PhD, is Professor and Program Director of the Center for Environmental and Human Toxicology at the University of Florida, Gainesville, FL.Robert C. James, PhD, is Senior Science Advisor, ToxStrategies, Boise, ID. Phillip L. Williams, PhD, is Dean and Professor Emeritus, College of Public Health, University of Georgia, Athens, GA.

• 1 General Principles of ToxicologyRobert C. James, Stephen M. Roberts, and Phillip L. Williams2 Xenobiotic Absorption, Distribution, Metabolism and ExcretionMichael R. Franklin3 ToxicokineticsRebecca A. Clewell and Harvey J. Clewell III4 Regulatory ToxicologyRaymond M. David5 Alternative Methods in Toxicity TestingLeona D. Scanlan, XuefeiCao, and Christopher D. Vulpe6 ComputationalToxicologyRichard S. Judson, David M. Reif, Keith A. Houck, Thomas B. Knudsen, Joshua Harrill, Katie Paul Friedman7 Hematotoxicity:Toxic Effects on the Hematopoietic SystemLila Ramaiah, Tara Arndt, and Michelle Cora8 Hepatotoxicity: Toxic Effects on the LiveRobert C. James and Stephen M. Roberts9 Nephrotoxicity: Toxic Effects on the KidneyLawrence H. Lash10 Neurotoxicology: Toxic Effects on the Nervous SystemW. Michael Caudle, Meghan Bucher, Alexandria C. White, and Gary W. Miller11 Dermal Toxicology: Toxic Effects on the SkinSailesh Konda and Howard I Maibach12 Pulmonotoxicity: Toxic Effects on the Respiratory SystemCuiqing Liu and Qinghua Sun13 Immunotoxicity: Toxic Effects on the Immune SystemEric S. Sobel and Stephen M. Roberts14 Reproductive and Developmental Toxicity: Toxic Effects on the Female and Male Reproductive Tracts and OffspringShuo Xiao, Krista Symosko, and Charles A. Easley IV15 Mutagenesis and Genetic ToxicologyMartha M. Moore, Meagan B. Myers and Robert H. Heflich16 Chemical CarcinogenesisJames E. Klaunig, Luma Melo, and Karen Tilmant17 Properties and Effects of MetalsDavid B. Mayfield, Lisa A. Bailey, Joel M. Cohen, and Barbara D. Beck18 PesticidesJanice Britt19 Properties and Toxicology of Organic Solvents and Solvent-Like ChemicalsChristopher M. Teaf and Michele M. Garber20 NanotoxicologyHongbo Ma and Stephen M. Roberts21 Insights into EpidemiologyJ. Fryzek, C. Frankenfeld, N. Movva, L. Bylsma, and J. Acquavella22 Occupational and Environmental HealthLaura Breeher, Fredric Gerr, and T. Renėe Anthony23 Human Health Risk AssessmentLeah D. Stuchal24 Ecological Risk AssessmentBrett Thomas25 The Dilemma of Selecting Safe Exposure ValuesRobert C. James, Phillip L. Williams,and Stephen M. Roberts