The encyclopedia takes a broad, multidisciplinary approach to the history of the period. It includes general and specific entries on politics and business, labor, industry, agriculture, education and youth, law and legislative affairs, literature, music, the performing and visual arts, health and medicine, science and technology, exploration, life on the Western frontier, family life, slave life, Native American life, women, and more than a hundred influential individuals.

The encyclopedia takes a broad, multidisciplinary approach to the history of the period. It includes general and specific entries on politics and business, labor, industry, agriculture, education and youth, law and legislative affairs, literature, music, the performing and visual arts, health and medicine, science and technology, exploration, life on the Western frontier, family life, slave life, Native American life, women, and more than a hundred influential individuals.