Dr. Rodney A. White, MD. Chief, Vascular Surgery, Associate Chair, Department of Surgery, Harbor-UCLA Medical Center. Professor of Surgery UCLA School of Medicine.Larry H. Hollier, LSU School of Medicine in New Orleans.

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• Contributors viiPreface xiiiAcknowledgments xivI Vascular pathology and physiology1 Embryology and development of the vascular system 3C. Phifer Nicholson and Peter Gloviczki2 Vascular wall physiology 19Christian C. Haudenschild3 Hemostasis and coagulation 27Donald L. Jacobs and Jonathan B. Towne4 Molecular aspects of atherosclerosis 43J. Jeffrey Alexander and John A. Moawad5 Localization of atherosclerotic lesions 55Christopher K. Zarins, Chengpei Xu, Charles A. Taylor and Seymour Glagov6 Pathogenesis of arterial fibrodysplasia 66James C. Stanley7 Physiology of vasospastic disorders 80Scott E. Musicant, Jean-Baptiste Roullet, James M. Edwards and Gregory L. Moneta8 Buerger’s disease 92John Blebea and Richard F. Kempczinski9 Ergotism 101Roger F.J. Shepherd10 Arteritis 114Francis J. Kazmier11 Adventitial cystic disease 119Carlos E. Donayre12 Entrapment syndromes 126Carlos E. Donayre13 Intimal hyperplasia 135Ted R. Kohler14 Thoracic outlet syndrome 146Herbert I. Machleder15 Aneurysmal disease 162Juan Carlos Jimenez and Samuel Eric Wilson16 Pathophysiology of renovascular hypertension 180David L. Robaczewski, Richard H. Dean and Kimberley J. Hansen17 Pathophysiology hemodynamics and complications of venous disease 192Harold J. Welch, Kevin B. Raftery and Thomas F. O’Donnell Jr.18 Physiologic changes in lymphatic dysfunction 207Peter Gloviczki19 Physiologic changes in visceral ischemia 215Tina R. Desai, Joshua A. Tepper and Bruce L. Gewertz20 Natural history of atherosclerosis in the lower extremity carotid and coronary circulations 225Daniel B. Walsh21 Neurologic basis for sympathetically maintained pain: causalgia and reflex sympathetic dystrophy 233Marco Scoccianti and Rodney A. White22 Compartment syndromes physiology 241Malcolm O. Perry23 Physiology of reperfusion injury 245Shervanthi Homer-Vanniasinkam and D. Neil Granger24 Cerebral ischemia 251Hao Bui and Christian deVirgilio25 Pathophysiology of spinal cord ischemia 257Larry H. Hollier26 Vascular erectile dysfunction: mechanisms and current approaches 228Ralph G. DePalma27 Portal hypertension: pathophysiology and clinical correlates 275David Rigberg and Hugh A. GelabertII Noninvasive vascular diagnostics28 Physiologic basis of hemodynamic measurement 295R. Eugene Zierler29 Spectral analysis 306Christopher R.B. Merritt30 Ultrasound imaging 315Christopher R.B. Merritt31 Radionuclide scanning 325Robert E. Sonnemaker32 Computed tomography 348Anton Mlikotic and Irwin Walot33 Magnetic resonance imaging 371David Saloner, Rem van Tyen, Charles M. Anderson and Gary R. CaputoIII Invasive vascular diagnostics34 Angiography 385Anton Mlikotic and C. Mark Mehringer35 Intravascular ultrasound 401James T. Lee, George Kopchok and Rodney A. White36 Angioscopy in peripheral vascular surgery 423Arnold Miller and Thomas J. HölzenbeinIV Medical management37 Atherosclerosis: risk factors and medical management 441Ralph G. DePalma and Virginia W. Hayes38 Pharmacologic intervention: thrombolytic therapy 454Anthony J. Comerota, A. Koneti Rao and Mohammad H. Eslami39 Pharmacologic intervention: vasodilation therapy and rheologic agents 468George Johnson Jr.40 Pharmacologic intervention: lipid-lowering agents 473Ralph G. DePalma41 Infections and antibiotics in vascular surgery 477Martin R. BackV Endovascular interventions for vascular disease42 Catheter-based approaches to the treatment of atheroembolic disease 495Frank R. Arko, Christine Newman and Thomas J. Fogarty43 Balloon angioplasty and transluminal recanalization devices 503Rajesh Subramanian and Stephen R. Ramee44 Endovascular stents 516Frank J. Criado, Youssef Rizk, Gregory S. Domer and Hilde Jerius45 Endovascular prostheses for repair of abdominal aortic aneurysms 520Carlos E. DonayreVI Comparison of conventional vascular reconstruction and endovascular techniques46 Surgical and endovascular treatment of chronic ischemia of the lower limbs 533Jean-Paul P.M. de Vries, Frans L. Moll and Jos C. van den Berg47 Aortoiliac endovascular recanalization compared with surgical reconstruction 543Peter L. Faries and Michael L. Marin48 Endovascular stent–graft repair of thoracic aortic aneurysms and dissections 554Jason T. Lee and Rodney A. White49 Brachiocephalic vascular reconstructions compared with endovascular repair 567Edward B. Diethrich50 Carotid endarterectomy compared with carotid angioplasty and stenting 575Mark R. Harrigan, Ricardo A. Hanel, Elad I. Levy, Lee R. Guterman and L. Nelson Hopkins51 Endovascular intervention for venous occlusion compared with surgical reconstruction 587Patricia E. Thorpe and Francisco J. OsseIndex 609Colour plate section follows p.370

Dr. Rodney A. White, MD. Chief, Vascular Surgery, Associate Chair, Department of Surgery, Harbor-UCLA Medical Center. Professor of Surgery UCLA School of Medicine.Larry H. Hollier, LSU School of Medicine in New Orleans.

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• Contributors viiPreface xiiiAcknowledgments xivI Vascular pathology and physiology1 Embryology and development of the vascular system 3C. Phifer Nicholson and Peter Gloviczki2 Vascular wall physiology 19Christian C. Haudenschild3 Hemostasis and coagulation 27Donald L. Jacobs and Jonathan B. Towne4 Molecular aspects of atherosclerosis 43J. Jeffrey Alexander and John A. Moawad5 Localization of atherosclerotic lesions 55Christopher K. Zarins, Chengpei Xu, Charles A. Taylor and Seymour Glagov6 Pathogenesis of arterial fibrodysplasia 66James C. Stanley7 Physiology of vasospastic disorders 80Scott E. Musicant, Jean-Baptiste Roullet, James M. Edwards and Gregory L. Moneta8 Buerger’s disease 92John Blebea and Richard F. Kempczinski9 Ergotism 101Roger F.J. Shepherd10 Arteritis 114Francis J. Kazmier11 Adventitial cystic disease 119Carlos E. Donayre12 Entrapment syndromes 126Carlos E. Donayre13 Intimal hyperplasia 135Ted R. Kohler14 Thoracic outlet syndrome 146Herbert I. Machleder15 Aneurysmal disease 162Juan Carlos Jimenez and Samuel Eric Wilson16 Pathophysiology of renovascular hypertension 180David L. Robaczewski, Richard H. Dean and Kimberley J. Hansen17 Pathophysiology hemodynamics and complications of venous disease 192Harold J. Welch, Kevin B. Raftery and Thomas F. O’Donnell Jr.18 Physiologic changes in lymphatic dysfunction 207Peter Gloviczki19 Physiologic changes in visceral ischemia 215Tina R. Desai, Joshua A. Tepper and Bruce L. Gewertz20 Natural history of atherosclerosis in the lower extremity carotid and coronary circulations 225Daniel B. Walsh21 Neurologic basis for sympathetically maintained pain: causalgia and reflex sympathetic dystrophy 233Marco Scoccianti and Rodney A. White22 Compartment syndromes physiology 241Malcolm O. Perry23 Physiology of reperfusion injury 245Shervanthi Homer-Vanniasinkam and D. Neil Granger24 Cerebral ischemia 251Hao Bui and Christian deVirgilio25 Pathophysiology of spinal cord ischemia 257Larry H. Hollier26 Vascular erectile dysfunction: mechanisms and current approaches 228Ralph G. DePalma27 Portal hypertension: pathophysiology and clinical correlates 275David Rigberg and Hugh A. GelabertII Noninvasive vascular diagnostics28 Physiologic basis of hemodynamic measurement 295R. Eugene Zierler29 Spectral analysis 306Christopher R.B. Merritt30 Ultrasound imaging 315Christopher R.B. Merritt31 Radionuclide scanning 325Robert E. Sonnemaker32 Computed tomography 348Anton Mlikotic and Irwin Walot33 Magnetic resonance imaging 371David Saloner, Rem van Tyen, Charles M. Anderson and Gary R. CaputoIII Invasive vascular diagnostics34 Angiography 385Anton Mlikotic and C. Mark Mehringer35 Intravascular ultrasound 401James T. Lee, George Kopchok and Rodney A. White36 Angioscopy in peripheral vascular surgery 423Arnold Miller and Thomas J. HölzenbeinIV Medical management37 Atherosclerosis: risk factors and medical management 441Ralph G. DePalma and Virginia W. Hayes38 Pharmacologic intervention: thrombolytic therapy 454Anthony J. Comerota, A. Koneti Rao and Mohammad H. Eslami39 Pharmacologic intervention: vasodilation therapy and rheologic agents 468George Johnson Jr.40 Pharmacologic intervention: lipid-lowering agents 473Ralph G. DePalma41 Infections and antibiotics in vascular surgery 477Martin R. BackV Endovascular interventions for vascular disease42 Catheter-based approaches to the treatment of atheroembolic disease 495Frank R. Arko, Christine Newman and Thomas J. Fogarty43 Balloon angioplasty and transluminal recanalization devices 503Rajesh Subramanian and Stephen R. Ramee44 Endovascular stents 516Frank J. Criado, Youssef Rizk, Gregory S. Domer and Hilde Jerius45 Endovascular prostheses for repair of abdominal aortic aneurysms 520Carlos E. DonayreVI Comparison of conventional vascular reconstruction and endovascular techniques46 Surgical and endovascular treatment of chronic ischemia of the lower limbs 533Jean-Paul P.M. de Vries, Frans L. Moll and Jos C. van den Berg47 Aortoiliac endovascular recanalization compared with surgical reconstruction 543Peter L. Faries and Michael L. Marin48 Endovascular stent–graft repair of thoracic aortic aneurysms and dissections 554Jason T. Lee and Rodney A. White49 Brachiocephalic vascular reconstructions compared with endovascular repair 567Edward B. Diethrich50 Carotid endarterectomy compared with carotid angioplasty and stenting 575Mark R. Harrigan, Ricardo A. Hanel, Elad I. Levy, Lee R. Guterman and L. Nelson Hopkins51 Endovascular intervention for venous occlusion compared with surgical reconstruction 587Patricia E. Thorpe and Francisco J. OsseIndex 609Colour plate section follows p.370