Intestinal Failure

Alan N. Langnas, DO, is Chief of Transplantation and Director of the Liver and Intestinal Transplantation Program at the University of Nebraska Medical Center, Omaha, USA. Professor Langnas has been doing liver transplants at UNMC since 1988 and over the past seven years has performed more than 40 intestinal and intestinal/liver transplants, establishing the UNMC program as one of the top transplant centers in the world performing multiple organ transplants. Along side his transplant work, Professor Langnas also maintains an active practice treating non-transplant hepato-biliary patients and serves on the editorial boards of several medical journals. In addition to writing more than 100 research papers for medical journals, he is also active in several capacities with the United Network for Organ Sharing, the national organ allocation system in the U.S.Olivier Goulet, MD, PhD, Pediatric Gastroenterology-Hepatology and Nutrition, Reference Center for Rare Digestive Diseases, Integrated Program of Intestinal Failure, Home Parenteral Nutrition and Intestinal Transplantation, University of Paris-Descartes, Necker Hospital, Paris, France.Eamonn M.M. Quigley, MD, FRCP, FACP, FACG, FRCPI, is Professor of Medicine and Human Physiology and Head of the Medical School at the National University of Ireland (NUI), Cork. He also serves as Adjunct Professor of Medicine and Physiology at the University of Nebraska Medical Center in Omaha, USA. He is Editor-in-Chief of the American Journal of Gastroenterology and Vice-President of the World Organization of Gastroenterology (OMGE - Organisation Mondiale de Gastroentérologie). His major research interests are in the areas of motility, functional gastrointestinal disorders and gastrointestinal dysfunction in systemic disease. He has published over 400 original papers, reviews, editorials and book chapters and has received numerous awards from universities and societies worldwide.Kelly A. Tappenden, PhD, RD, is Associate Professor of Nutrition and Gastrointestinal Physiology in the Division of Nutritional Sciences at the University of Illinois at Urbana-Champaign, USA. Professor Tappenden recently received the 2005 American Society of Parenteral and Enteral Nutrition Dudrick Research Scholar Award and the 2004 College of Agricultural, Consumer and Environmental Sciences Faculty Award for Excellence in Research. Professor Tappenden's research interests include the regulation of small intestinal function by various nutrients and gastrointestinal-specific pepides. Her recent publications are featured in the Journal of Parenteral and Enteral Nutrition, Journal of Pediatric Gastroenterology and Nutrition and Journal of Nutrition. In addition to her academic research, Professor Tappenden is also a Registered Dietician, having completed clinical training at the Misericordia Hospital in Edmonton, Alberta.

"This is a useful, comprehensive, practical guide to modern assessment and management of complex intestinal failure cases. The book was compiled by experienced clinicians resulting in an authoritative, novel resource on intestinal failure." (Doody's Reviews, March 2009)"A comprehensive overview of the far-reaching effects of loss of the gut. It is a good update on state-of-the-art treatment of patients...and the authors also go behind the scenes to discuss aspects of care.... Intestinal Failure gives insight into recent progress in the understanding of intestinal failure, covers the most important topics that the clinician working in this area will face.... Despite major improvements in the survival of patients with severe intestinal failure, the treatment of patients with poor gut function remains an exciting and challenging area of medicine, and this book enables the reader to have a good overview and understanding of the topic." (New England Journal of Medicine, November 2008)

• List of Contributors, viiiForeword, xiiiPreface, xviiAbbreviations, xixPart 1 Introduction1 The History of Intestinal Failure and Transplantation, 3Alan N. LangnasPart 2 Intestinal Physiology and Immunology2 Intestinal Morphology, Intestinal Regeneration and the Promise of Tissue Engineering, 13David A.J. Lloyd and Simon M. Gabe3 Basic Physiology of Motility, Absorption and Secretion, 20Greger Lindberg4 Immunology of the Small Intestine, 33Liam O'Mahony5 Intestinal Adaptation: The Biology of the Intestinal Response to Resection and Disease, 45Marc S. Levin and Deborah C. RubinPart 3 Intestinal Failure: Definition and Pathophysiology6 Intestinal Failure: Definitions and Classifications, 57Dominique M. Jan7 Causes of Intestinal Failure in the Newborn, 66Yigael Finkel8 Congenital Enteropathies Causing Permanent Intestinal Failure, 77Olivier Goulet9 Causes of Intestinal Failure in the Adult, 88Harry C. Sax10 Intestinal Failure Related to Bariatric Surgery, 93Jon S. Thompson11 Inflammatory Bowel Disease and the Short Bowel Syndrome, 99Ramsey K. Umar and Alan L. Buchman12 Motility Disorders, 107Hayat Mousa and Carlo Di LorenzoPart 4 Assessment and General Management of Intestinal Failure13 Assessment of Intestinal Failure Patients, 117Clarivet Torres14 Guidelines for Home Parenteral Nutrition Support in Chronic Intestinal Failure Patients, 122Bernard Messing, Francisca Joly and Virginie Colomb15 Home Parenteral Nutrition: Complications, Survival, Costs and Quality of Life, 130John K. DiBaise16 Vascular Access, Including Complications, 142Sanja Kola¡cek and Julije Me¡strovi´c17 Enteral Support for Children with Intestinal Failure, 151Daniel S. Kamin and Christopher Duggan18 The Use of Enteral Nutrition in the Adult with Intestinal Failure, 160Khursheed N. Jeejeebhoy19 The Enteric Flora in Intestinal Failure: Small Intestinal Bacterial Overgrowth and Gut-Derived Sepsis, 167Eamonn M.M. Quigley, Rodrigo Quera and Ahmed Abu-Shanab20 Management of Complex Fluid and Electrolyte Disturbances, 185Stuart S. Kaufman and Erin M. Fennelly21 Intestinal Failure-Associated Liver Disease, 191Sue V. Beath and Jeremy M. Woodward22 Psychiatric Issues in the Assessment of the Patient with Intestinal Failure, 201James H. Sorrell23 Munchausen Syndrome by Proxy, 206Paul E. Hyman and Brenda BurschPart 5 Pharmacological Approaches to Intestinal Failure24 Luminal Nutrient Factors in Intestinal Adaptation and Their Use in Therapy, 215Jon A. Vanderhoof and Rosemary J. Young25 The Role of Humoral Factors in Intestinal Adaptation, 223Jennifer N. Woodard and Kelly A. TappendenPart 6 Autologous Reconstruction of the GI Tract26 Autologous Reconstruction of the GI Tract, 231Debra SudanPart 7 Organ Replacement Therapy for Intestinal Failure27 Intestinal Transplantation: Indications and Patient Selection, 245Kareem M. Abu-Elmagd28 Isolated Small Bowel Transplantation and Combined Liver-Small Bowel Transplantation, 254Douglas G. Farmer29 Living Donor Intestinal Transplantation, 262Enrico Benedetti, Fabrizio Panaro and Giuliano Testa30 Isolated Liver Transplantation for Intestinal Failure-Associated Liver Disease, 270Jean F. Botha and Alan N. Langnas31 Preservation of the Intestine, 275Vincent B. Nieuwenhuijs, Mihai Oltean, Henri G. Leuvenink and Rutger J. Ploeg32 Immediate Postoperative Care of the Intestinal Transplant Recipient, 283Gabriel J. Hauser, Jeffrey S. Plotkin and Thomas Fishbein33 Surgical Complications of Intestinal Transplantation, 290Wendy J. Grant34 Infections in Small Bowel Transplant Recipients, 297Alison Freifeld and Andre Kalil35 Immunosuppression after Intestinal Transplantation, 305Raquel Garcia-Roca and Rainer Gruessner36 Immunology of Intestinal Allograft Rejection, 314Kenneth A. Newell and Jonathan P. Fryer37 Histopathology of Intestinal Transplantation, 322Tong Wu and Anthony J. Demetris38 Long-Term Management of Intestinal Transplant Recipients, 331Frances R. Malone and Simon P. Horslen39 Management of Posttransplant Lymphoproliferative Disease, 342Thomas G. Gross40 Results of Intestinal Transplantation, 349David R. Grant and Shimul A. Shah41 Psychosocial Assessment and Management of the Transplant Patient/Family in Intestinal Transplantation, 357Jodi Gentleman, Leonard W. Penkoski and James H. Sorrell42 Financial, Economic and Insurance Issues Pertaining to Intestinal Transplantation: When Is Too Much Not Enough?, 363Roger W. EvansIndex, 379