Raymond Powrie MD FRCP FACP, Professor of Medicine, Obstetrics, and Gynecology, The Warren Alpert School of Medicine of Brown University, and Women & Infants Hospital of RI, USA Michael F Greene MD, Professor of Obstetrics & Gynecology, Harvard Medical School and Massachusetts General Hospital, MA, USAWilliam Camann MD, Chief of Obstetric Anesthesia, Brigham and Women's Hospital and Harvard Medical School. He is also the present President of the Society of Obstetric Anesthesiologists and Perinatologists

"This is a solid book for those interested in the care of obstetrical patients with medical problems. It has a grand vision and attempts to satisfy many parties. This newest edition adds some new wrinkles, justifying its publication." (Doody's, 16 September 2011) "Overall, this book is a useful resource for general and high risk obstetricians. It covers many aspects of medical diseases and problems in pregnancy. I would definitely use this book as a reference and I do recommend it to others ." (Sultan Qaboos University Medical Journal, 1 February 2011)

• List of Contributors viiPreface xiForeword xii1. Pulmonary disease in pregnancy 1Lucia Larson, Niharika Mehta, Michael J. Paglia, Ghada Bourjeily with Warwick D. Ngan Kee2. Hematologic disease in pregnancy 48Claire McLintock, John T. Repke with Brenda Bucklin3. Thromboembolic disease in pregnancy 82Catherine Nelson-Piercy and Ian Greer4. Thrombophilias and pregnancy 101Marc A. Rodger, Michael Paidas with Lawrence Tsen and Joanne Douglas5. Heart disease in pregnancy 118Cynthia Maxwell, Athena Poppas, Mathew Sermer with Elizabeth McGrady6. Hypertension in pregnancy 153Christopher W. G. Redman, Sig-Linda Jacobson with Robin Russell7. Renal disease in pregnancy 182Mark A. Brown, George J. Mangos, Michael Peek with Felicity Plaat8. Rheumatologic disorders in pregnancy 209Megan E. B. Clowse, Michelle Petri and Andra H. James9. Disorders of the liver, biliary system and exocrine pancreas in pregnancy 223Sailesh Kumar, Mrinalini Balki and Catherine Williamson (with Eliana Castillo andDeborah M. Money)10. Disorders of the gastrointestinal tract in pregnancy 256Niharika Mehta, Sumona Saha, Edward K.S. Chien with Silvia Degli Esposti and Scott Segal11. Diabetes mellitus in pregnancy 293Michael F. Greene, Caren G. Solomon, Stephanie L. Lee with Robert A. Peterfreund12. Thyroid disease in pregnancy 322Erin Keely and Brian M. Casey13. Pituitary and adrenal disease in pregnancy 335Mark E. Molitch and Alan Peaceman14. Calcium metabolism and diseases of the parathyroid glands during pregnancy 352Martin N. Montoro and T. Murphy Goodwin15. Neurologic disorders in obstetric practice 371Dominic C. Heaney, David J. Williams, Patrick O’Brien with Chris Elton16. Nonviral infectious diseases in pregnancy 404Brenna Anderson, Melissa Gaitanis with Daniel I. Sessler17. Viral infections in pregnancy other than human immunodeficiency virus 431Eliana Castillo and Deborah M. Money18. Human immunodeficiency virus infection in pregnancy 464Ruth E. Tuomala, Judith S. Currier, Susan Cu-Uvin with Roshan Fernando19. Substance misuse in pregnancy 477Ilana B. Crome, Khaled M. K. Ismail with David Birnbach20. Skin diseases in pregnancy 505Mark Davis, Brian Brost with Nollag O’Rourke21. Psychiatric disorders in pregnancy 524Teri Pearlstein and Jami Star22. Cancer in pregnancy 553Sunanda Sadanandan, Timothy Hurley, Carolyn Muller, Claire Verschraegen, Marianne Berwick, Charles L. Wiggins and Kimberly K. Leslie23. Critical care in pregnancy 583Uma Munnur, Dilip R. Karnad, Edward R. Yeomans and Kalpalatha K. Guntupalli24. Embryologic and fetal development 59825. Global issues in maternal health 599Rudiger Pittrof, Moke Magoma, Vêronique Filippi with Medge D. Owen26. Future health concerns for women who have had a complicated pregnancy 606David J. Williams41. Approach to proteinuria identified remote from term 704Margaret A. Miller42. Approach to new-onset hypertension remote from term 710Margaret A. Miller27. Special concerns for the obese patient 615Hugh M. Ehrenberg with Richard N. Wissler28. Special concerns for patients with advanced maternal age 621Linda Heffner29. Principles of obstetric anesthesia 625Stephen Gatt and William Camann30. Prescribing in pregnancy: a practical approach 633Sandra L. Kweder and Raymond O. Powrie31. Prescribing during lactation 641Thomas W. Hale and Teresa Baker32. Diagnostic imaging in pregnancy 646Sandra A. Lowe33. Contraception for women with medical disorders 653Iris Tong and Raymond O. Powrie34. Effect of pregnancy on common laboratory tests 661Michael Carson and Elvis R. Pagan35. Approach to headaches in pregnancy 671Jessica Illuzzi, Emma Barber and Men-Jean Lee36. Approach to anemia in pregnancy 681Dorothy Graham and Jami Star37. Approach to moderately elevated liver function tests in pregnancy not attributable to pre-eclampsia/HELLP syndrome 684Margaret A. Miller38. Approach to shortness of breath in pregnancy 689Ghada Bourjeily, Hanan Khalil and Michael J. Paglia43. Approach to presyncope and syncope in pregnancy 715Paul S. Gibson, Rshmi Khurana and Winnie W. Sia44. Approach to chest pain in pregnancy 719Rshmi Khurana, Winnie W. Sia and Paul S. Gibson45. New-onset seizures in pregnancy 724Laura A. Magee, Anne-Marie Côté and Peter von Dadelszen46. Approach to prosthetic heart valves in pregnancy 730Wee Shian Chan, Mark C. Walker and Marc A. Rodger47. Approach to the use of glucocorticoids in pregnancy for nonobstetric indications 736Kenneth K. Chen and Raymond O. Powrie48. Approach to hyperemesis gravidarum 742Sumona Saha, Catherine Williamson, Niharika Mehta, Edward K.S. Chien and Silvia Degli Esposti49. Approach to fetal assessment, optimization of neonatal outcome, mode of delivery and timing for nonobstetric readers 749Michael Peek, George J. Mangos and Mark A. Brown50. Promoting safe care for women with medical problems during pregnancy 754Raymond O. Powrie, James A. O’Brien with Kue Chung Choi39. Approach to hypertensive emergencies in pregnancy 695Laura A. Magee and Peter von Dadelszen with David Wlody40. Approach to palpitations in pregnancy, 700Winnie W. Sia, Paul S. Gibson and Rshmi KhuranaAppendix: Medications and their relative risk to breastfeeding infants 759Index 771

Raymond Powrie MD FRCP FACP, Professor of Medicine, Obstetrics, and Gynecology, The Warren Alpert School of Medicine of Brown University, and Women & Infants Hospital of RI, USA Michael F Greene MD, Professor of Obstetrics & Gynecology, Harvard Medical School and Massachusetts General Hospital, MA, USAWilliam Camann MD, Chief of Obstetric Anesthesia, Brigham and Women's Hospital and Harvard Medical School. He is also the present President of the Society of Obstetric Anesthesiologists and Perinatologists

"This is a solid book for those interested in the care of obstetrical patients with medical problems. It has a grand vision and attempts to satisfy many parties. This newest edition adds some new wrinkles, justifying its publication." (Doody's, 16 September 2011) "Overall, this book is a useful resource for general and high risk obstetricians. It covers many aspects of medical diseases and problems in pregnancy. I would definitely use this book as a reference and I do recommend it to others ." (Sultan Qaboos University Medical Journal, 1 February 2011)

• List of Contributors viiPreface xiForeword xii1. Pulmonary disease in pregnancy 1Lucia Larson, Niharika Mehta, Michael J. Paglia, Ghada Bourjeily with Warwick D. Ngan Kee2. Hematologic disease in pregnancy 48Claire McLintock, John T. Repke with Brenda Bucklin3. Thromboembolic disease in pregnancy 82Catherine Nelson-Piercy and Ian Greer4. Thrombophilias and pregnancy 101Marc A. Rodger, Michael Paidas with Lawrence Tsen and Joanne Douglas5. Heart disease in pregnancy 118Cynthia Maxwell, Athena Poppas, Mathew Sermer with Elizabeth McGrady6. Hypertension in pregnancy 153Christopher W. G. Redman, Sig-Linda Jacobson with Robin Russell7. Renal disease in pregnancy 182Mark A. Brown, George J. Mangos, Michael Peek with Felicity Plaat8. Rheumatologic disorders in pregnancy 209Megan E. B. Clowse, Michelle Petri and Andra H. James9. Disorders of the liver, biliary system and exocrine pancreas in pregnancy 223Sailesh Kumar, Mrinalini Balki and Catherine Williamson (with Eliana Castillo andDeborah M. Money)10. Disorders of the gastrointestinal tract in pregnancy 256Niharika Mehta, Sumona Saha, Edward K.S. Chien with Silvia Degli Esposti and Scott Segal11. Diabetes mellitus in pregnancy 293Michael F. Greene, Caren G. Solomon, Stephanie L. Lee with Robert A. Peterfreund12. Thyroid disease in pregnancy 322Erin Keely and Brian M. Casey13. Pituitary and adrenal disease in pregnancy 335Mark E. Molitch and Alan Peaceman14. Calcium metabolism and diseases of the parathyroid glands during pregnancy 352Martin N. Montoro and T. Murphy Goodwin15. Neurologic disorders in obstetric practice 371Dominic C. Heaney, David J. Williams, Patrick O’Brien with Chris Elton16. Nonviral infectious diseases in pregnancy 404Brenna Anderson, Melissa Gaitanis with Daniel I. Sessler17. Viral infections in pregnancy other than human immunodeficiency virus 431Eliana Castillo and Deborah M. Money18. Human immunodeficiency virus infection in pregnancy 464Ruth E. Tuomala, Judith S. Currier, Susan Cu-Uvin with Roshan Fernando19. Substance misuse in pregnancy 477Ilana B. Crome, Khaled M. K. Ismail with David Birnbach20. Skin diseases in pregnancy 505Mark Davis, Brian Brost with Nollag O’Rourke21. Psychiatric disorders in pregnancy 524Teri Pearlstein and Jami Star22. Cancer in pregnancy 553Sunanda Sadanandan, Timothy Hurley, Carolyn Muller, Claire Verschraegen, Marianne Berwick, Charles L. Wiggins and Kimberly K. Leslie23. Critical care in pregnancy 583Uma Munnur, Dilip R. Karnad, Edward R. Yeomans and Kalpalatha K. Guntupalli24. Embryologic and fetal development 59825. Global issues in maternal health 599Rudiger Pittrof, Moke Magoma, Vêronique Filippi with Medge D. Owen26. Future health concerns for women who have had a complicated pregnancy 606David J. Williams41. Approach to proteinuria identified remote from term 704Margaret A. Miller42. Approach to new-onset hypertension remote from term 710Margaret A. Miller27. Special concerns for the obese patient 615Hugh M. Ehrenberg with Richard N. Wissler28. Special concerns for patients with advanced maternal age 621Linda Heffner29. Principles of obstetric anesthesia 625Stephen Gatt and William Camann30. Prescribing in pregnancy: a practical approach 633Sandra L. Kweder and Raymond O. Powrie31. Prescribing during lactation 641Thomas W. Hale and Teresa Baker32. Diagnostic imaging in pregnancy 646Sandra A. Lowe33. Contraception for women with medical disorders 653Iris Tong and Raymond O. Powrie34. Effect of pregnancy on common laboratory tests 661Michael Carson and Elvis R. Pagan35. Approach to headaches in pregnancy 671Jessica Illuzzi, Emma Barber and Men-Jean Lee36. Approach to anemia in pregnancy 681Dorothy Graham and Jami Star37. Approach to moderately elevated liver function tests in pregnancy not attributable to pre-eclampsia/HELLP syndrome 684Margaret A. Miller38. Approach to shortness of breath in pregnancy 689Ghada Bourjeily, Hanan Khalil and Michael J. Paglia43. Approach to presyncope and syncope in pregnancy 715Paul S. Gibson, Rshmi Khurana and Winnie W. Sia44. Approach to chest pain in pregnancy 719Rshmi Khurana, Winnie W. Sia and Paul S. Gibson45. New-onset seizures in pregnancy 724Laura A. Magee, Anne-Marie Côté and Peter von Dadelszen46. Approach to prosthetic heart valves in pregnancy 730Wee Shian Chan, Mark C. Walker and Marc A. Rodger47. Approach to the use of glucocorticoids in pregnancy for nonobstetric indications 736Kenneth K. Chen and Raymond O. Powrie48. Approach to hyperemesis gravidarum 742Sumona Saha, Catherine Williamson, Niharika Mehta, Edward K.S. Chien and Silvia Degli Esposti49. Approach to fetal assessment, optimization of neonatal outcome, mode of delivery and timing for nonobstetric readers 749Michael Peek, George J. Mangos and Mark A. Brown50. Promoting safe care for women with medical problems during pregnancy 754Raymond O. Powrie, James A. O’Brien with Kue Chung Choi39. Approach to hypertensive emergencies in pregnancy 695Laura A. Magee and Peter von Dadelszen with David Wlody40. Approach to palpitations in pregnancy, 700Winnie W. Sia, Paul S. Gibson and Rshmi KhuranaAppendix: Medications and their relative risk to breastfeeding infants 759Index 771