Polymorphism in Pharmaceutical Solids

Inbunden, Engelska, 2009

Del i serien Drugs and the Pharmaceutical Sciences

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Beskrivning

Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins. Topics include: Computational methodologiesHigh-throughput screening methodsPharmaceutical cocrystalsThermally-induced and solution-mediated phase transformationsAmorphous solids Crystallography preparation and characterization The amorphous state

Produktinformation

Utgivningsdatum:2009-07-27
Mått:152 x 229 x 40 mm
Vikt:975 g
Format:Inbunden
Språk:Engelska
Serie:Drugs and the Pharmaceutical Sciences
Antal sidor:652
Upplaga:2
Förlag:Taylor & Francis Inc
ISBN:9781420073218

Utforska kategorier

Tillverkningsteknik inom Naturvetenskap och teknik
Fysikalisk kemi inom Naturvetenskap och teknik
Kemi inom Naturvetenskap och teknik

Innehållsförteckning

1. Thermodynamic and Theoretical Issues. 1.1. Theory and Origin of Polymorphism. 1.2. Application of the Phase Rule. 1.3. Computational Methodologies. 2. Preparative Methods for Polymorphs and Solvatomorphs. 2.1. Classical Methods of Preparation. 2.2. High-Throughput Screening Methods. 3. Structural Properties of Polymorphs and Solvatomorphs. 3.1. Polymorphic Systems. 3.2. Solvatomorphic Systems. 3.3. Pharmaceutical Cocrystals. 4. Characterization Methods for Polymorphs and Solvatomorphs. 4.1. Thermal and Crystallographic. 4.2. Vibrational Spectroscopy. 4.3. Solid-State NMR. 4.4. Solubility and Dissolution Rate. 5. Interconversion of Polymorphs and Solvatomorphs. 5.1. Thermally-Induced and Solution-Mediated Phase Transformations. 5.2. Effects of Secondary Processing. 5.3. Structural Aspects of Molecular Dissymmetry. 5.4. Amorphous Solids.