The National Defense Authorization Act of 2016 mandates a review of missile defeat policy, strategy, and capability to be completed by January 2018. This upcoming Missile Defeat Review (MDR) represents an opportunity for the Trump administration to articulate a vision for the future of air and missile defense. This collection of expert essays explores how the strategic environment for missile defense and defeat has evolved since 2010 and offers recommendations to help guide and inform the MDR’s development.