Yoav Ben-Shlomo is Professor of Clinical Epidemiology, School of Social and Community Medicine, University of Bristol.Sara T. Brookes is Senior Lecturer in Health Services Research & Medical Statistics, School of Social and Community Medicine, University of Bristol.Matthew Hickman is Professor in Public Health and Epidemiology, School of Social and Community Medicine, University of Bristol.

This introductory overview for pre-med and medical students, public health students, and junior doctorssets out key concepts, processes, measurements, and types of studies in epidemiology, and outlinesmajor elements of evidence-based medicine, with chapters on diagnosis, prognosis, effectiveness,systematic reviews and meta-analysis, health economics, and research ethics. Final chapters on publichealth discuss healthcare inequalities. This sixth edition contains new chapters on genetic epidemiologyand on global health and climate change, along with new global case studies. The reader-friendly colorlayout features objectives, boxes, checklists, key points, charts, and process illustrations. Otherlearning features include a glossary and in-depth case quizzes with explained answers. Each chapterends with further reading and a list of web sites. Editor Ben-Schlomo teaches clinical epidemiology atthe University of Bristol, UK. (Book News, June 2013)

• Preface, viList of contributors, viiiPart 1 Epidemiology1 Epidemiology: defining disease and normality, 3Sara T. Brookes and Yoav Ben-Shlomo2 Measuring and summarising data, 11Sara T. Brookes and Yoav Ben-Shlomo3 Epidemiological concepts, 20Sara T. Brookes and Yoav Ben-Shlomo4 Statistical inference, confidence intervals and P-values, 26Kate Tilling, Sara T. Brookes and Jonathan A.C. Sterne5 Observational studies, 36Mona Jeffreys and Yoav Ben-Shlomo6 Genetic epidemiology, 46David M. Evans and Ian N.M. Day7 Investigating causes of disease, 55Debbie A. Lawlor and John MacleodSelf-assessment questions – Part 1: Epidemiology, 63Part 2 Evidence-based Medicine8 An overview of evidence-based medicine, 69Yoav Ben-Shlomo andMatthew Hickman9 Diagnosis, 74Penny Whiting and Richard M.Martin10 Prognosis, 84Yoav Ben-Shlomo andMatthew Hickman11 Effectiveness, 92Sara T. Brookes and Jenny Donovan12 Systematic reviews and meta-analysis, 102Penny Whiting and Jonathan Sterne13 Health economics, 112William Hollingworth and Sian Noble14 Audit, research ethics and research governance, 120Joanne Simon and Yoav Ben-ShlomoSelf-assessment questions – Part 2: Evidence-based medicine, 128Part 3 Public Health15 Public health, 135Matthew Hickman, Ruth Kipping and David Gunnell16 Screening, 145Angela E. Raffle17 Infectious disease epidemiology and surveillance, 152Caroline Trotter, Isabel Oliver and Matthew Hickman18 Inequalities in health, 160Bruna Galobardes,Mona Jeffreys, and George Davey Smith19 Health improvement, 170Bruce Bolam20 Evaluating public health and complex interventions, 177Yoav Ben-Shlomo and Rona Campbell21 Health care targets, 184Maya Gobin and Gabriel Scally22 Global health, 191Sanjay Kinra, David L. Heymann and Shah EbrahimSelf-assessment questions – Part 3: Public health, 202Glossary of terms, 205Self-assessment answers – Part 1: Epidemiology, 221Self-assessment answers – Part 2: Evidencebased medicine, 224Self-assessment answers – Part 3: Public health, 228Index, 233

Yoav Ben-Shlomo is Professor of Clinical Epidemiology, School of Social and Community Medicine, University of Bristol.Sara T. Brookes is Senior Lecturer in Health Services Research & Medical Statistics, School of Social and Community Medicine, University of Bristol.Matthew Hickman is Professor in Public Health and Epidemiology, School of Social and Community Medicine, University of Bristol.

This introductory overview for pre-med and medical students, public health students, and junior doctorssets out key concepts, processes, measurements, and types of studies in epidemiology, and outlinesmajor elements of evidence-based medicine, with chapters on diagnosis, prognosis, effectiveness,systematic reviews and meta-analysis, health economics, and research ethics. Final chapters on publichealth discuss healthcare inequalities. This sixth edition contains new chapters on genetic epidemiologyand on global health and climate change, along with new global case studies. The reader-friendly colorlayout features objectives, boxes, checklists, key points, charts, and process illustrations. Otherlearning features include a glossary and in-depth case quizzes with explained answers. Each chapterends with further reading and a list of web sites. Editor Ben-Schlomo teaches clinical epidemiology atthe University of Bristol, UK. (Book News, June 2013)

• Preface, viList of contributors, viiiPart 1 Epidemiology1 Epidemiology: defining disease and normality, 3Sara T. Brookes and Yoav Ben-Shlomo2 Measuring and summarising data, 11Sara T. Brookes and Yoav Ben-Shlomo3 Epidemiological concepts, 20Sara T. Brookes and Yoav Ben-Shlomo4 Statistical inference, confidence intervals and P-values, 26Kate Tilling, Sara T. Brookes and Jonathan A.C. Sterne5 Observational studies, 36Mona Jeffreys and Yoav Ben-Shlomo6 Genetic epidemiology, 46David M. Evans and Ian N.M. Day7 Investigating causes of disease, 55Debbie A. Lawlor and John MacleodSelf-assessment questions – Part 1: Epidemiology, 63Part 2 Evidence-based Medicine8 An overview of evidence-based medicine, 69Yoav Ben-Shlomo andMatthew Hickman9 Diagnosis, 74Penny Whiting and Richard M.Martin10 Prognosis, 84Yoav Ben-Shlomo andMatthew Hickman11 Effectiveness, 92Sara T. Brookes and Jenny Donovan12 Systematic reviews and meta-analysis, 102Penny Whiting and Jonathan Sterne13 Health economics, 112William Hollingworth and Sian Noble14 Audit, research ethics and research governance, 120Joanne Simon and Yoav Ben-ShlomoSelf-assessment questions – Part 2: Evidence-based medicine, 128Part 3 Public Health15 Public health, 135Matthew Hickman, Ruth Kipping and David Gunnell16 Screening, 145Angela E. Raffle17 Infectious disease epidemiology and surveillance, 152Caroline Trotter, Isabel Oliver and Matthew Hickman18 Inequalities in health, 160Bruna Galobardes,Mona Jeffreys, and George Davey Smith19 Health improvement, 170Bruce Bolam20 Evaluating public health and complex interventions, 177Yoav Ben-Shlomo and Rona Campbell21 Health care targets, 184Maya Gobin and Gabriel Scally22 Global health, 191Sanjay Kinra, David L. Heymann and Shah EbrahimSelf-assessment questions – Part 3: Public health, 202Glossary of terms, 205Self-assessment answers – Part 1: Epidemiology, 221Self-assessment answers – Part 2: Evidencebased medicine, 224Self-assessment answers – Part 3: Public health, 228Index, 233

Yoav Ben-Shlomo is Professor of Clinical Epidemiology, School of Social and Community Medicine, University of Bristol.Sara T. Brookes is Senior Lecturer in Health Services Research & Medical Statistics, School of Social and Community Medicine, University of Bristol.Matthew Hickman is Professor in Public Health and Epidemiology, School of Social and Community Medicine, University of Bristol.

This introductory overview for pre-med and medical students, public health students, and junior doctorssets out key concepts, processes, measurements, and types of studies in epidemiology, and outlinesmajor elements of evidence-based medicine, with chapters on diagnosis, prognosis, effectiveness,systematic reviews and meta-analysis, health economics, and research ethics. Final chapters on publichealth discuss healthcare inequalities. This sixth edition contains new chapters on genetic epidemiologyand on global health and climate change, along with new global case studies. The reader-friendly colorlayout features objectives, boxes, checklists, key points, charts, and process illustrations. Otherlearning features include a glossary and in-depth case quizzes with explained answers. Each chapterends with further reading and a list of web sites. Editor Ben-Schlomo teaches clinical epidemiology atthe University of Bristol, UK. (Book News, June 2013)

• Preface, viList of contributors, viiiPart 1 Epidemiology1 Epidemiology: defining disease and normality, 3Sara T. Brookes and Yoav Ben-Shlomo2 Measuring and summarising data, 11Sara T. Brookes and Yoav Ben-Shlomo3 Epidemiological concepts, 20Sara T. Brookes and Yoav Ben-Shlomo4 Statistical inference, confidence intervals and P-values, 26Kate Tilling, Sara T. Brookes and Jonathan A.C. Sterne5 Observational studies, 36Mona Jeffreys and Yoav Ben-Shlomo6 Genetic epidemiology, 46David M. Evans and Ian N.M. Day7 Investigating causes of disease, 55Debbie A. Lawlor and John MacleodSelf-assessment questions – Part 1: Epidemiology, 63Part 2 Evidence-based Medicine8 An overview of evidence-based medicine, 69Yoav Ben-Shlomo andMatthew Hickman9 Diagnosis, 74Penny Whiting and Richard M.Martin10 Prognosis, 84Yoav Ben-Shlomo andMatthew Hickman11 Effectiveness, 92Sara T. Brookes and Jenny Donovan12 Systematic reviews and meta-analysis, 102Penny Whiting and Jonathan Sterne13 Health economics, 112William Hollingworth and Sian Noble14 Audit, research ethics and research governance, 120Joanne Simon and Yoav Ben-ShlomoSelf-assessment questions – Part 2: Evidence-based medicine, 128Part 3 Public Health15 Public health, 135Matthew Hickman, Ruth Kipping and David Gunnell16 Screening, 145Angela E. Raffle17 Infectious disease epidemiology and surveillance, 152Caroline Trotter, Isabel Oliver and Matthew Hickman18 Inequalities in health, 160Bruna Galobardes,Mona Jeffreys, and George Davey Smith19 Health improvement, 170Bruce Bolam20 Evaluating public health and complex interventions, 177Yoav Ben-Shlomo and Rona Campbell21 Health care targets, 184Maya Gobin and Gabriel Scally22 Global health, 191Sanjay Kinra, David L. Heymann and Shah EbrahimSelf-assessment questions – Part 3: Public health, 202Glossary of terms, 205Self-assessment answers – Part 1: Epidemiology, 221Self-assessment answers – Part 2: Evidencebased medicine, 224Self-assessment answers – Part 3: Public health, 228Index, 233