Pierre-Alain Clavien, MD, PhD, FACS, FRCS (Eng), FRCS (Ed), Professor and Chairman, Department of Surgery. Head, Division of Visceral & Transplantation Surgery, University Hospital Zurich, SwitzerlandProfessor Clavien is a world-wide renowned surgeon-scientist, currently professor and chairman of the Department of Surgery in Zurich, Switzerland. His areas of research include organ preservation, liver ischemia-reperfusion injury and regeneration, and pathogenesis of cancer, as well as outcome research. He received many competitive grants and awards, including one of the most prestigious prices for scientific research, the Otto Naegeli Award. Dr James Trotter is the Medical Director of Liver Transplantation at Baylor University Medical Center at Dallas. Dr. Trotter's primary interests include end-stage liver disease and the management of liver transplant candidates and recipients. Dr. Trotter specializes in hepatitis C, ascites, complications of portal hypertension, including esophageal varices and hepatic encephalopathy. He also has vast experience in the management of medical complications after liver transplantation including immunosuppression in liver transplant recipients and the treatment of hepatitis C before and after liver transplantation.

“I can recommend the book with enthusiasm. It will find a place on my bookshelf.”  (Gastroenterology, 1 December 2012)“This new edition does a good job addressing more current issues in liver transplantation. It succinctly provides an excellent base of understanding, guiding readers through a variety of indications for liver transplantation to help them understand the operative and chronic management of these patients.”  (Doody’s, 20 July 2012)

• Contributors, ix Preface, xvPart 1 Management of the potential transplant recipient1 Selection and evaluation of the recipient (including retransplantation), 3Audrey Coilly and Didier Samuel2 Monitoring the patient awaiting liver transplantation, 13Andreas Geier and Beat Müllhaupt3 Management of portal hypertension, 26Juan Carlos Garcia-Pagan, Juan G. Abraldes and Jaime Bosch4 Management of renal disease in the liver transplant candidate, 39Andrés Cárdenas and Pere Ginès5 Management of hepatopulmonary syndrome and portopulmonary hypertension, 51Victor I. Machicao and Michael B. Fallon6 Psychiatric and substance abuse evaluation of the potential liver transplant recipient, 62Thomas P. Beresford7 Organ allocation in liver transplantation: ethics, organ supply, and evidencebased practice, 75Nicole Siparsky, David Axelrod and Richard B. Freeman8 Viral hepatitis and transplantation, 88Geoffrey W. McCaughan9 Metabolic liver diseases, 97Maureen M.J. Guichelaar and Michael R. Charlton10 Cholestatic and autoimmune liver disease, 110Ulrich Beuers11 Hepatocellular carcinoma, 121Maria Reig, Alejandro Forner and Jordi Bruix12 Cholangiocarcinoma, 133Howard C. Masuoka, Gregory J. Gores and Charles B. Rosen13 Rare indications for liver transplantation, 145Stevan A. Gonzalez14 Liver transplantation in HIV patients, 155Marion G. Peters and Peter G. Stock15 Living-donor liver transplantation, 162Robert S. Brown Jr16 Fulminant hepatic failure, 176Michael A. Heneghan and William BernalPart 2 Donor issues and management in the perioperative period17 Extended-criteria donor, 191Ashraf Mohammad El-Badry and Mickael Lesurtel18 Liver transplantation using donors after cardiac death, 201Paolo Muiesan, Laura Tariciotti and Chiara Rocha19 Transmission of malignancies and infection through donor organs, 216Aaron M. Winnick and Lewis Teperman20 The transplant operation, 229Philipp Dutkowski, Olivier de Rougemont and Pierre-Alain Clavien21 Difficult surgical patients, 238Philipp Dutkowski, Stefan Breitenstein and Pierre-Alain Clavien22 Domino and split-liver transplantation, 246Abhideep Chaudhary and Abhinav Humar23 Surgical aspects of living-donor transplantation, 255Kelvin K.C. Ng and Sheung Tat Fan24 Anesthesia, 266Beatrice Beck-Schimmer25 Coagulation and blood transfusion management, 276Herman G.D. Hendriks, Ton Lisman and Robert J. Porte26 Critical care of the liver transplant recipient, 286Markus Béchir, Erik Schadde and Philipp Dutkowski27 Rejection and immunosuppression trends in liver transplantation, 297James F. Trotter28 Vascular complications after liver transplantation, 311Goran Klintmalm and Srinath Chinnakotla29 Biliary complications following liver transplantation, 319Sanna op den Dries, Robert C. Verdonk and Robert J. Porte30 Role of histopathology, 332Achim WeberPart 3 Chronic problems in the transplant recipient31 Medical problems after liver transplantation, 347Eberhard L. Renner and Marco Puglia32 Prevention and treatment of recurrent HBV and HCV infection, 361Ed Gane33 Recurrence of the original disease, 372James Neuberger34 Infections in the liver transplant recipient, 380Nicolas J. Mueller and Jay A. Fishman35 Cutaneous diseases in liver transplant recipients, 389Sylvie Euvrard and Jean Kanitakis36 Post-transplant lymphoproliferative disorder and other malignancies after liver transplantation, 398Natasha Chandok and Kymberly D.S. Watt37 Sexual function and fertility after liver transplantation, 406Andreas Geier and Beat MüllhauptPart 4 Pediatric liver transplantation38 Special considerations in pediatric liver transplantation, 419Brandy Ries Lu and Ronald J. SokolMultiple choice questions, 431Answers, 446Index, 451

Pierre-Alain Clavien, MD, PhD, FACS, FRCS (Eng), FRCS (Ed), Professor and Chairman, Department of Surgery. Head, Division of Visceral & Transplantation Surgery, University Hospital Zurich, SwitzerlandProfessor Clavien is a world-wide renowned surgeon-scientist, currently professor and chairman of the Department of Surgery in Zurich, Switzerland. His areas of research include organ preservation, liver ischemia-reperfusion injury and regeneration, and pathogenesis of cancer, as well as outcome research. He received many competitive grants and awards, including one of the most prestigious prices for scientific research, the Otto Naegeli Award. Dr James Trotter is the Medical Director of Liver Transplantation at Baylor University Medical Center at Dallas. Dr. Trotter's primary interests include end-stage liver disease and the management of liver transplant candidates and recipients. Dr. Trotter specializes in hepatitis C, ascites, complications of portal hypertension, including esophageal varices and hepatic encephalopathy. He also has vast experience in the management of medical complications after liver transplantation including immunosuppression in liver transplant recipients and the treatment of hepatitis C before and after liver transplantation.

“I can recommend the book with enthusiasm. It will find a place on my bookshelf.”  (Gastroenterology, 1 December 2012)“This new edition does a good job addressing more current issues in liver transplantation. It succinctly provides an excellent base of understanding, guiding readers through a variety of indications for liver transplantation to help them understand the operative and chronic management of these patients.”  (Doody’s, 20 July 2012)

• Contributors, ix Preface, xvPart 1 Management of the potential transplant recipient1 Selection and evaluation of the recipient (including retransplantation), 3Audrey Coilly and Didier Samuel2 Monitoring the patient awaiting liver transplantation, 13Andreas Geier and Beat Müllhaupt3 Management of portal hypertension, 26Juan Carlos Garcia-Pagan, Juan G. Abraldes and Jaime Bosch4 Management of renal disease in the liver transplant candidate, 39Andrés Cárdenas and Pere Ginès5 Management of hepatopulmonary syndrome and portopulmonary hypertension, 51Victor I. Machicao and Michael B. Fallon6 Psychiatric and substance abuse evaluation of the potential liver transplant recipient, 62Thomas P. Beresford7 Organ allocation in liver transplantation: ethics, organ supply, and evidencebased practice, 75Nicole Siparsky, David Axelrod and Richard B. Freeman8 Viral hepatitis and transplantation, 88Geoffrey W. McCaughan9 Metabolic liver diseases, 97Maureen M.J. Guichelaar and Michael R. Charlton10 Cholestatic and autoimmune liver disease, 110Ulrich Beuers11 Hepatocellular carcinoma, 121Maria Reig, Alejandro Forner and Jordi Bruix12 Cholangiocarcinoma, 133Howard C. Masuoka, Gregory J. Gores and Charles B. Rosen13 Rare indications for liver transplantation, 145Stevan A. Gonzalez14 Liver transplantation in HIV patients, 155Marion G. Peters and Peter G. Stock15 Living-donor liver transplantation, 162Robert S. Brown Jr16 Fulminant hepatic failure, 176Michael A. Heneghan and William BernalPart 2 Donor issues and management in the perioperative period17 Extended-criteria donor, 191Ashraf Mohammad El-Badry and Mickael Lesurtel18 Liver transplantation using donors after cardiac death, 201Paolo Muiesan, Laura Tariciotti and Chiara Rocha19 Transmission of malignancies and infection through donor organs, 216Aaron M. Winnick and Lewis Teperman20 The transplant operation, 229Philipp Dutkowski, Olivier de Rougemont and Pierre-Alain Clavien21 Difficult surgical patients, 238Philipp Dutkowski, Stefan Breitenstein and Pierre-Alain Clavien22 Domino and split-liver transplantation, 246Abhideep Chaudhary and Abhinav Humar23 Surgical aspects of living-donor transplantation, 255Kelvin K.C. Ng and Sheung Tat Fan24 Anesthesia, 266Beatrice Beck-Schimmer25 Coagulation and blood transfusion management, 276Herman G.D. Hendriks, Ton Lisman and Robert J. Porte26 Critical care of the liver transplant recipient, 286Markus Béchir, Erik Schadde and Philipp Dutkowski27 Rejection and immunosuppression trends in liver transplantation, 297James F. Trotter28 Vascular complications after liver transplantation, 311Goran Klintmalm and Srinath Chinnakotla29 Biliary complications following liver transplantation, 319Sanna op den Dries, Robert C. Verdonk and Robert J. Porte30 Role of histopathology, 332Achim WeberPart 3 Chronic problems in the transplant recipient31 Medical problems after liver transplantation, 347Eberhard L. Renner and Marco Puglia32 Prevention and treatment of recurrent HBV and HCV infection, 361Ed Gane33 Recurrence of the original disease, 372James Neuberger34 Infections in the liver transplant recipient, 380Nicolas J. Mueller and Jay A. Fishman35 Cutaneous diseases in liver transplant recipients, 389Sylvie Euvrard and Jean Kanitakis36 Post-transplant lymphoproliferative disorder and other malignancies after liver transplantation, 398Natasha Chandok and Kymberly D.S. Watt37 Sexual function and fertility after liver transplantation, 406Andreas Geier and Beat MüllhauptPart 4 Pediatric liver transplantation38 Special considerations in pediatric liver transplantation, 419Brandy Ries Lu and Ronald J. SokolMultiple choice questions, 431Answers, 446Index, 451

Pierre-Alain Clavien, MD, PhD, FACS, FRCS (Eng), FRCS (Ed), Professor and Chairman, Department of Surgery. Head, Division of Visceral & Transplantation Surgery, University Hospital Zurich, SwitzerlandProfessor Clavien is a world-wide renowned surgeon-scientist, currently professor and chairman of the Department of Surgery in Zurich, Switzerland. His areas of research include organ preservation, liver ischemia-reperfusion injury and regeneration, and pathogenesis of cancer, as well as outcome research. He received many competitive grants and awards, including one of the most prestigious prices for scientific research, the Otto Naegeli Award. Dr James Trotter is the Medical Director of Liver Transplantation at Baylor University Medical Center at Dallas. Dr. Trotter's primary interests include end-stage liver disease and the management of liver transplant candidates and recipients. Dr. Trotter specializes in hepatitis C, ascites, complications of portal hypertension, including esophageal varices and hepatic encephalopathy. He also has vast experience in the management of medical complications after liver transplantation including immunosuppression in liver transplant recipients and the treatment of hepatitis C before and after liver transplantation.

“I can recommend the book with enthusiasm. It will find a place on my bookshelf.”  (Gastroenterology, 1 December 2012)“This new edition does a good job addressing more current issues in liver transplantation. It succinctly provides an excellent base of understanding, guiding readers through a variety of indications for liver transplantation to help them understand the operative and chronic management of these patients.”  (Doody’s, 20 July 2012)

• Contributors, ix Preface, xvPart 1 Management of the potential transplant recipient1 Selection and evaluation of the recipient (including retransplantation), 3Audrey Coilly and Didier Samuel2 Monitoring the patient awaiting liver transplantation, 13Andreas Geier and Beat Müllhaupt3 Management of portal hypertension, 26Juan Carlos Garcia-Pagan, Juan G. Abraldes and Jaime Bosch4 Management of renal disease in the liver transplant candidate, 39Andrés Cárdenas and Pere Ginès5 Management of hepatopulmonary syndrome and portopulmonary hypertension, 51Victor I. Machicao and Michael B. Fallon6 Psychiatric and substance abuse evaluation of the potential liver transplant recipient, 62Thomas P. Beresford7 Organ allocation in liver transplantation: ethics, organ supply, and evidencebased practice, 75Nicole Siparsky, David Axelrod and Richard B. Freeman8 Viral hepatitis and transplantation, 88Geoffrey W. McCaughan9 Metabolic liver diseases, 97Maureen M.J. Guichelaar and Michael R. Charlton10 Cholestatic and autoimmune liver disease, 110Ulrich Beuers11 Hepatocellular carcinoma, 121Maria Reig, Alejandro Forner and Jordi Bruix12 Cholangiocarcinoma, 133Howard C. Masuoka, Gregory J. Gores and Charles B. Rosen13 Rare indications for liver transplantation, 145Stevan A. Gonzalez14 Liver transplantation in HIV patients, 155Marion G. Peters and Peter G. Stock15 Living-donor liver transplantation, 162Robert S. Brown Jr16 Fulminant hepatic failure, 176Michael A. Heneghan and William BernalPart 2 Donor issues and management in the perioperative period17 Extended-criteria donor, 191Ashraf Mohammad El-Badry and Mickael Lesurtel18 Liver transplantation using donors after cardiac death, 201Paolo Muiesan, Laura Tariciotti and Chiara Rocha19 Transmission of malignancies and infection through donor organs, 216Aaron M. Winnick and Lewis Teperman20 The transplant operation, 229Philipp Dutkowski, Olivier de Rougemont and Pierre-Alain Clavien21 Difficult surgical patients, 238Philipp Dutkowski, Stefan Breitenstein and Pierre-Alain Clavien22 Domino and split-liver transplantation, 246Abhideep Chaudhary and Abhinav Humar23 Surgical aspects of living-donor transplantation, 255Kelvin K.C. Ng and Sheung Tat Fan24 Anesthesia, 266Beatrice Beck-Schimmer25 Coagulation and blood transfusion management, 276Herman G.D. Hendriks, Ton Lisman and Robert J. Porte26 Critical care of the liver transplant recipient, 286Markus Béchir, Erik Schadde and Philipp Dutkowski27 Rejection and immunosuppression trends in liver transplantation, 297James F. Trotter28 Vascular complications after liver transplantation, 311Goran Klintmalm and Srinath Chinnakotla29 Biliary complications following liver transplantation, 319Sanna op den Dries, Robert C. Verdonk and Robert J. Porte30 Role of histopathology, 332Achim WeberPart 3 Chronic problems in the transplant recipient31 Medical problems after liver transplantation, 347Eberhard L. Renner and Marco Puglia32 Prevention and treatment of recurrent HBV and HCV infection, 361Ed Gane33 Recurrence of the original disease, 372James Neuberger34 Infections in the liver transplant recipient, 380Nicolas J. Mueller and Jay A. Fishman35 Cutaneous diseases in liver transplant recipients, 389Sylvie Euvrard and Jean Kanitakis36 Post-transplant lymphoproliferative disorder and other malignancies after liver transplantation, 398Natasha Chandok and Kymberly D.S. Watt37 Sexual function and fertility after liver transplantation, 406Andreas Geier and Beat MüllhauptPart 4 Pediatric liver transplantation38 Special considerations in pediatric liver transplantation, 419Brandy Ries Lu and Ronald J. SokolMultiple choice questions, 431Answers, 446Index, 451