Pierre-Alain Clavien – författare

Over the last two decades, there have been major advances in imaging, endoscopy, and laparoscopy in the field of gastrointestinal (GI) surgery. GI surgery is the newest sub-specialty branch of general surgery, where enhanced expertise and high-volume centres have made a difference to the outcomes of complex operations. Surgeons can now do difficult procedures with low morbidity and mortality rates, and greatly improved overall results.This volume provides detailed and up-to-date knowledge on diseases of the liver, gall bladder, and bile ducts. Split into two sections, it covers anatomy and physiology, approaches to specific conditions and traumas, a thorough analysis of current knowledge and future advances in the field, and a review of the relevant literature.Written and edited by world-renowned experts in the field, this book will be a valuable resource for hepatobiliary surgeons and trainees, general surgeons, researchers, and medical students.

Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format.With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: AutophagyNotch PathwayP13K/PTEN Signaling in Liver DiseasesSirtuinsHepcidin and IronEpigenetic Regulation of Hepatic Stellate Cells and Liver FibrosisOxidative Stress and Signaling in the Liver.Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge.Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

Medical Care of the Liver Transplant Patient looks at monitoring and maintaining the health of organ recipients and donors, pre, during and post-operatively. There are twenty-nine chapters containing practical advice on total patient management. They are arranged into 8 sections and follow the stages of transplantation from first indication and selection of potential recipient, through to acute recovery, long-term follow-up and continued health. In this edition there are new chapters on special considerations in liver transplant patients such as viral hepatitis, alcoholic liver disease and live donor liver transplantation. It also contains the very latest information concerning complications and recurring problems after transplantation. Another new chapter considers fresh approaches and developments in the future. This is a vital reference to all members of the medical team involved at different stages in the care of liver transplantation patients including hepatologists, gastroenterologists, transplant surgeons, specialist nurses, and nutritionists.

This comprehensive and critical review of current and established treatment modalities for malignant liver tumors is designed to help you sort through the proliferation of competitive approaches and choose the best treatment options for your patient. Dr. Clavien and his contributors consider all the options – radiological, surgical, pharmaceutical, and emerging/novel therapies – and help you find the best single or combined therapy. Building on the success of the previous edition, this extremely thorough revision: features a new section on Guidelines for Liver Tumors, where you will find specific strategies for treating common liver malignancies; the guidelines were prepared by the Associate Editors and take into account national and international society guidelinesreflects actual practice by taking a multidisciplinary approach, with contributions from international experts who have extensive experience with this patient populationachieves comprehensive and balanced coverage by having each chapter reviewed by the Editor, Deputy Editor, two Associate Editors, and at least one external reviewerincludes 16 new chapters that cover liver anatomy, histologic changes in the liver, epidemiology and natural history of HCC, CCC and colorectal liver metastases, strategies of liver resection, and economic aspects as well as novel therapiesfacilitates the kind of daily interaction among hepatologists, hepatic surgeons, medical oncologists, radiotherapists, and interventional radiologists that is essential when treating patients with complex liver malignanciesIn 44 chapters organized into six major sections, the book covers the full range of liver tumors. The perfect blend of evidence and experience, Malignant Liver Tumors: Current and Emerging Therapies, 3rd Edition, illuminates the path to better patient care.

This book builds on the success of previous editions, once again providing hepatologists the most current clinical guide on how to best treat the liver transplant recipient. With an international mix of experienced contributors, this new edition highlights initial indication and selection of the potential recipient, management of the donor organ, post-operative complications in the patient through to acute recovery, long-term follow-up, and continued health. This provides the user a complete guide to the correct clinical management of both the recipient and the donor organ through all stages of transplantation.

Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.

The first edition of this book was judged by many to be the best available atlas of upper gastrointestinal and hepato-pancreato-biliary surgery. General, oncologic, and transplantation surgical procedures are described step by step with the aid of more than 900 superb illustrations drawn by a team of artists with extensive experience.