Edited byGary S. Hoffman MD, MS Professor of Medicine Department of Rheumatic and Immunologic Diseases Center for Vasculitis Care and Research Cleveland Clinic Lerner College of Medicine Cleveland, OH, USA Cornelia M. Weyand MD, PhD Professor of Medicine Stanford University School of Medicine Stanford, CA, USA Carol A. Langford MD, MHS Director, Center for Vasculitis Care and Research Department of Rheumatic and Immunologic Diseases Cleveland Clinic Lerner College of Medicine Cleveland, OH, USA Jörg J. Goronzy MD, PhD Professor of Medicine Stanford University School of Medicine Stanford, CA, USA

“This book provides a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease.”  (European Journal of Immunology, 1 December 2012)“Overall, this is an excellent source of information on vasculitis for physicians at any level, including practicing rheumatologists.”  (Doody’s, 2 November 2012)

• List of Contributors PrefaceSection I. Biology of Blood Vessels and Mechanisms of Vascular Inflammation1 Vascular DevelopmentDomenico Ribatti and Enrico Crivellato2 Vascular RepairChristian Troidl, Kerstin Troidl, Georg Jung, Thomas Schmitz-Rixen and Wolfgang Schaper3 Leukocyte TraffickingBraedon McDonald and Paul Kubes4 Dendritic Cells and Vascular InflammationCornelia M. Weyand5 T Cells and Vascular InflammationJörg J. Goronzy6 Autoantibodies and Vascular InflammationA.Rutgers, J.S.F. Sanders, J.W. Cohen Tervaert, C.G.M. Kallenberg7 Neutrophils and Vascular InflammationMatthew David Morgan and Caroline OS Savage8 Cytokines and Vascular InflammationMaria C Cid, Marc Corbera-Bellalta, Ester Planas-Rigol, Ester Lozano, Georgina Espígol-Frigolé, Ana García-Martínez, José Hernández-Rodríguez, Marta Segarra9 Oxidative Stress and Vascular InflammationDavid G. Harrison10 Hemostasis and Vascular InflammationLawrence Leung and John Morser11 Animal Models of VasculitisMasato Nose12 Arteries, Smooth Muscle Cells, and Genetic Causes of Thoracic Aortic AneurysmsAmy J. Reid and Dianna M. Milewicz13 Innate Immunity in AtherosclerosisShuang Chen, Prediman K. Shah and Moshe Arditi14 Adaptive Immunity in AtherosclerosisJan NilssonSection II. Primary Autoimmune Vascular Diseases15 Historical Perspectives VasculitisEric L. Matteson16 Approach to the Differential Diagnosis of VasculitisEamonn S. Molloy and Carol A. Langford17 Imaging of medium and large vessels (CT/PET/MR)Thorsten Alexander Bley18 Kawasaki diseaseRae S.M. Yeung19 Henoch-Schonlein PurpuraPhilip J. Hashkes and Alexandra Villa-Forte20 Polyarteritis NodosaEli M. Miloslavsky and John H. Stone21 Microscopic polyangiitisCoen Stegeman22 Granulomatosis with Polyangiitis (Wegener's Granulomatosis)Gary S. Hoffman, Carol A. Langford and Ulrich Specks23 Churg–Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis, EGPA)Christian Pagnoux and Loïc Guillevin24 Giant cell arteritisCornelia M. Weyand and Jörg J. Goronzy25 Takayasu's arteritisKathleen Maksimowicz-McKinnon and Gary S. Hoffman26 Behçet's SyndromeYusuf Yazici, Ismail Simsek and Hasan Yazici27 Cogan's SyndromeRex M. McCallum and E. William St. Clair28 Idiopathic cryoglobulinemic vasculitidesBenjamin Terrier and Patrice Cacoub29 Primary central nervous system vasculitisRula A. Hajj-Ali and Leonard H. Calabrese30 Single organ vasculitisJosé Hernández-Rodríguez and Gary S. Hoffman31 Primary cutaneous vasculitisJeffrey P. Callen32 Buerger's disease (thromboangiitis obliterans)Ahmet Ruchan Akar and M. Serkan DurduSection III. Secondary Causes of Vasculitis33 Virus-associated vasculitidesDimitrios Vassilopoulos and Leonard H. Calabrese34 Drug-induced vasculitisPeter A. Merkel35 Rheumatoid vasculitisKimberly P. Liang, Carl Turesson, Larry W. Moreland36 Vasculopathy/Vasculitis and progressive systemic sclerosisNezam Altorok, Omar R. Kahaly and Bashar Kahaleh37 Vasculitis and Sjögren's syndromeGeorge E. Fragoulis and Haralampos M. Moutsopoulos38 Vasculitis in systemic lupus erythematosusRicardo Garcia and Andras Perl39 Vasculitis in the Idiopathic Inflammatory MyopathiesFrederick W. Miller and Chester V. Oddis40 Vasculitis and relapsing polychondritisTanaz A. Kermani and Kenneth J. Warrington41 Systemic Vasculitis in SarcoidosisAlexandra Villa-Forte and Gary S. Hoffman42 Vasculitis as a Paraneoplastic Syndrome and Direct Tumour Invasion of VesselsClaire E. Barber and Simon CaretteSection IV. Recognizing Risks and Treating Damage from Vasculitis43 Cholesterol and Modifications of Cholesterol in Rheumatic DisordersJan Willem Cohen Tervaert44 Prevention and treatment of medical complicationsAtul Khasnis and Carol A. Langford45 Ophthalmic Risks and Complications Aassociated with the Treatment of Systemic VasculitisSteven Yeh and James T. Rosenbaum46 Subglottic Stenosis of Granulomatosis with Polyangiitis (Wegener's Granulomatosis)Rahul Seth and Daniel S. Alam47 Sino-Nasal Manifestations of Granulomatosis with Polyangiitis (Wegener's Granulomatosis)Daniel S. Alam, Rahul Seth, Raj Sindwani48 Neurologic Damage of VasculitisC. David Lin49 Endstage Renal Disease and VasculitisKirsten de Groot and Charles Pusey50 Cardiothoracic Surgery for Takayasu's Arteritis and Giant Cell ArteritisTurki Albacker and Lars Svensson51 Peripheral Vascular Surgery for Takayasu's Arteritis and Giant Cell ArteritisRavi R. Rajani and Vikram S. KashyapIndex

Edited byGary S. Hoffman MD, MS Professor of Medicine Department of Rheumatic and Immunologic Diseases Center for Vasculitis Care and Research Cleveland Clinic Lerner College of Medicine Cleveland, OH, USA Cornelia M. Weyand MD, PhD Professor of Medicine Stanford University School of Medicine Stanford, CA, USA Carol A. Langford MD, MHS Director, Center for Vasculitis Care and Research Department of Rheumatic and Immunologic Diseases Cleveland Clinic Lerner College of Medicine Cleveland, OH, USA Jörg J. Goronzy MD, PhD Professor of Medicine Stanford University School of Medicine Stanford, CA, USA

“This book provides a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease.”  (European Journal of Immunology, 1 December 2012)“Overall, this is an excellent source of information on vasculitis for physicians at any level, including practicing rheumatologists.”  (Doody’s, 2 November 2012)

• List of Contributors PrefaceSection I. Biology of Blood Vessels and Mechanisms of Vascular Inflammation1 Vascular DevelopmentDomenico Ribatti and Enrico Crivellato2 Vascular RepairChristian Troidl, Kerstin Troidl, Georg Jung, Thomas Schmitz-Rixen and Wolfgang Schaper3 Leukocyte TraffickingBraedon McDonald and Paul Kubes4 Dendritic Cells and Vascular InflammationCornelia M. Weyand5 T Cells and Vascular InflammationJörg J. Goronzy6 Autoantibodies and Vascular InflammationA.Rutgers, J.S.F. Sanders, J.W. Cohen Tervaert, C.G.M. Kallenberg7 Neutrophils and Vascular InflammationMatthew David Morgan and Caroline OS Savage8 Cytokines and Vascular InflammationMaria C Cid, Marc Corbera-Bellalta, Ester Planas-Rigol, Ester Lozano, Georgina Espígol-Frigolé, Ana García-Martínez, José Hernández-Rodríguez, Marta Segarra9 Oxidative Stress and Vascular InflammationDavid G. Harrison10 Hemostasis and Vascular InflammationLawrence Leung and John Morser11 Animal Models of VasculitisMasato Nose12 Arteries, Smooth Muscle Cells, and Genetic Causes of Thoracic Aortic AneurysmsAmy J. Reid and Dianna M. Milewicz13 Innate Immunity in AtherosclerosisShuang Chen, Prediman K. Shah and Moshe Arditi14 Adaptive Immunity in AtherosclerosisJan NilssonSection II. Primary Autoimmune Vascular Diseases15 Historical Perspectives VasculitisEric L. Matteson16 Approach to the Differential Diagnosis of VasculitisEamonn S. Molloy and Carol A. Langford17 Imaging of medium and large vessels (CT/PET/MR)Thorsten Alexander Bley18 Kawasaki diseaseRae S.M. Yeung19 Henoch-Schonlein PurpuraPhilip J. Hashkes and Alexandra Villa-Forte20 Polyarteritis NodosaEli M. Miloslavsky and John H. Stone21 Microscopic polyangiitisCoen Stegeman22 Granulomatosis with Polyangiitis (Wegener's Granulomatosis)Gary S. Hoffman, Carol A. Langford and Ulrich Specks23 Churg–Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis, EGPA)Christian Pagnoux and Loïc Guillevin24 Giant cell arteritisCornelia M. Weyand and Jörg J. Goronzy25 Takayasu's arteritisKathleen Maksimowicz-McKinnon and Gary S. Hoffman26 Behçet's SyndromeYusuf Yazici, Ismail Simsek and Hasan Yazici27 Cogan's SyndromeRex M. McCallum and E. William St. Clair28 Idiopathic cryoglobulinemic vasculitidesBenjamin Terrier and Patrice Cacoub29 Primary central nervous system vasculitisRula A. Hajj-Ali and Leonard H. Calabrese30 Single organ vasculitisJosé Hernández-Rodríguez and Gary S. Hoffman31 Primary cutaneous vasculitisJeffrey P. Callen32 Buerger's disease (thromboangiitis obliterans)Ahmet Ruchan Akar and M. Serkan DurduSection III. Secondary Causes of Vasculitis33 Virus-associated vasculitidesDimitrios Vassilopoulos and Leonard H. Calabrese34 Drug-induced vasculitisPeter A. Merkel35 Rheumatoid vasculitisKimberly P. Liang, Carl Turesson, Larry W. Moreland36 Vasculopathy/Vasculitis and progressive systemic sclerosisNezam Altorok, Omar R. Kahaly and Bashar Kahaleh37 Vasculitis and Sjögren's syndromeGeorge E. Fragoulis and Haralampos M. Moutsopoulos38 Vasculitis in systemic lupus erythematosusRicardo Garcia and Andras Perl39 Vasculitis in the Idiopathic Inflammatory MyopathiesFrederick W. Miller and Chester V. Oddis40 Vasculitis and relapsing polychondritisTanaz A. Kermani and Kenneth J. Warrington41 Systemic Vasculitis in SarcoidosisAlexandra Villa-Forte and Gary S. Hoffman42 Vasculitis as a Paraneoplastic Syndrome and Direct Tumour Invasion of VesselsClaire E. Barber and Simon CaretteSection IV. Recognizing Risks and Treating Damage from Vasculitis43 Cholesterol and Modifications of Cholesterol in Rheumatic DisordersJan Willem Cohen Tervaert44 Prevention and treatment of medical complicationsAtul Khasnis and Carol A. Langford45 Ophthalmic Risks and Complications Aassociated with the Treatment of Systemic VasculitisSteven Yeh and James T. Rosenbaum46 Subglottic Stenosis of Granulomatosis with Polyangiitis (Wegener's Granulomatosis)Rahul Seth and Daniel S. Alam47 Sino-Nasal Manifestations of Granulomatosis with Polyangiitis (Wegener's Granulomatosis)Daniel S. Alam, Rahul Seth, Raj Sindwani48 Neurologic Damage of VasculitisC. David Lin49 Endstage Renal Disease and VasculitisKirsten de Groot and Charles Pusey50 Cardiothoracic Surgery for Takayasu's Arteritis and Giant Cell ArteritisTurki Albacker and Lars Svensson51 Peripheral Vascular Surgery for Takayasu's Arteritis and Giant Cell ArteritisRavi R. Rajani and Vikram S. KashyapIndex

Edited byGary S. Hoffman MD, MS Professor of Medicine Department of Rheumatic and Immunologic Diseases Center for Vasculitis Care and Research Cleveland Clinic Lerner College of Medicine Cleveland, OH, USA Cornelia M. Weyand MD, PhD Professor of Medicine Stanford University School of Medicine Stanford, CA, USA Carol A. Langford MD, MHS Director, Center for Vasculitis Care and Research Department of Rheumatic and Immunologic Diseases Cleveland Clinic Lerner College of Medicine Cleveland, OH, USA Jörg J. Goronzy MD, PhD Professor of Medicine Stanford University School of Medicine Stanford, CA, USA

“This book provides a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease.”  (European Journal of Immunology, 1 December 2012)“Overall, this is an excellent source of information on vasculitis for physicians at any level, including practicing rheumatologists.”  (Doody’s, 2 November 2012)

• List of Contributors PrefaceSection I. Biology of Blood Vessels and Mechanisms of Vascular Inflammation1 Vascular DevelopmentDomenico Ribatti and Enrico Crivellato2 Vascular RepairChristian Troidl, Kerstin Troidl, Georg Jung, Thomas Schmitz-Rixen and Wolfgang Schaper3 Leukocyte TraffickingBraedon McDonald and Paul Kubes4 Dendritic Cells and Vascular InflammationCornelia M. Weyand5 T Cells and Vascular InflammationJörg J. Goronzy6 Autoantibodies and Vascular InflammationA.Rutgers, J.S.F. Sanders, J.W. Cohen Tervaert, C.G.M. Kallenberg7 Neutrophils and Vascular InflammationMatthew David Morgan and Caroline OS Savage8 Cytokines and Vascular InflammationMaria C Cid, Marc Corbera-Bellalta, Ester Planas-Rigol, Ester Lozano, Georgina Espígol-Frigolé, Ana García-Martínez, José Hernández-Rodríguez, Marta Segarra9 Oxidative Stress and Vascular InflammationDavid G. Harrison10 Hemostasis and Vascular InflammationLawrence Leung and John Morser11 Animal Models of VasculitisMasato Nose12 Arteries, Smooth Muscle Cells, and Genetic Causes of Thoracic Aortic AneurysmsAmy J. Reid and Dianna M. Milewicz13 Innate Immunity in AtherosclerosisShuang Chen, Prediman K. Shah and Moshe Arditi14 Adaptive Immunity in AtherosclerosisJan NilssonSection II. Primary Autoimmune Vascular Diseases15 Historical Perspectives VasculitisEric L. Matteson16 Approach to the Differential Diagnosis of VasculitisEamonn S. Molloy and Carol A. Langford17 Imaging of medium and large vessels (CT/PET/MR)Thorsten Alexander Bley18 Kawasaki diseaseRae S.M. Yeung19 Henoch-Schonlein PurpuraPhilip J. Hashkes and Alexandra Villa-Forte20 Polyarteritis NodosaEli M. Miloslavsky and John H. Stone21 Microscopic polyangiitisCoen Stegeman22 Granulomatosis with Polyangiitis (Wegener's Granulomatosis)Gary S. Hoffman, Carol A. Langford and Ulrich Specks23 Churg–Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis, EGPA)Christian Pagnoux and Loïc Guillevin24 Giant cell arteritisCornelia M. Weyand and Jörg J. Goronzy25 Takayasu's arteritisKathleen Maksimowicz-McKinnon and Gary S. Hoffman26 Behçet's SyndromeYusuf Yazici, Ismail Simsek and Hasan Yazici27 Cogan's SyndromeRex M. McCallum and E. William St. Clair28 Idiopathic cryoglobulinemic vasculitidesBenjamin Terrier and Patrice Cacoub29 Primary central nervous system vasculitisRula A. Hajj-Ali and Leonard H. Calabrese30 Single organ vasculitisJosé Hernández-Rodríguez and Gary S. Hoffman31 Primary cutaneous vasculitisJeffrey P. Callen32 Buerger's disease (thromboangiitis obliterans)Ahmet Ruchan Akar and M. Serkan DurduSection III. Secondary Causes of Vasculitis33 Virus-associated vasculitidesDimitrios Vassilopoulos and Leonard H. Calabrese34 Drug-induced vasculitisPeter A. Merkel35 Rheumatoid vasculitisKimberly P. Liang, Carl Turesson, Larry W. Moreland36 Vasculopathy/Vasculitis and progressive systemic sclerosisNezam Altorok, Omar R. Kahaly and Bashar Kahaleh37 Vasculitis and Sjögren's syndromeGeorge E. Fragoulis and Haralampos M. Moutsopoulos38 Vasculitis in systemic lupus erythematosusRicardo Garcia and Andras Perl39 Vasculitis in the Idiopathic Inflammatory MyopathiesFrederick W. Miller and Chester V. Oddis40 Vasculitis and relapsing polychondritisTanaz A. Kermani and Kenneth J. Warrington41 Systemic Vasculitis in SarcoidosisAlexandra Villa-Forte and Gary S. Hoffman42 Vasculitis as a Paraneoplastic Syndrome and Direct Tumour Invasion of VesselsClaire E. Barber and Simon CaretteSection IV. Recognizing Risks and Treating Damage from Vasculitis43 Cholesterol and Modifications of Cholesterol in Rheumatic DisordersJan Willem Cohen Tervaert44 Prevention and treatment of medical complicationsAtul Khasnis and Carol A. Langford45 Ophthalmic Risks and Complications Aassociated with the Treatment of Systemic VasculitisSteven Yeh and James T. Rosenbaum46 Subglottic Stenosis of Granulomatosis with Polyangiitis (Wegener's Granulomatosis)Rahul Seth and Daniel S. Alam47 Sino-Nasal Manifestations of Granulomatosis with Polyangiitis (Wegener's Granulomatosis)Daniel S. Alam, Rahul Seth, Raj Sindwani48 Neurologic Damage of VasculitisC. David Lin49 Endstage Renal Disease and VasculitisKirsten de Groot and Charles Pusey50 Cardiothoracic Surgery for Takayasu's Arteritis and Giant Cell ArteritisTurki Albacker and Lars Svensson51 Peripheral Vascular Surgery for Takayasu's Arteritis and Giant Cell ArteritisRavi R. Rajani and Vikram S. KashyapIndex