Optimal management of device associated infections requires a collaborative approach among surgical and medical specialists-a need that is central to this issue of Infectious Diseases Clinics of North America.� In addition to the epidemiology, management, and prevention of commonly encountered device associated infections, each review offers technical background on specific devices and related operative procedures.�� Areas of ongoing investigation are highlighted including innovative concepts for the prevention of biofilm formation and biofilm directed therapeutics.� Emerging issues related to reuse of medical devices in resource limited settings are also considered.