Molecular Mechanisms of Werner’s Syndrome

AvMichel Lebel

Häftad, Engelska, 2012

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Beskrivning

To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.

Produktinformation

Utgivningsdatum:2012-11-06
Mått:156 x 234 x 10 mm
Vikt:266 g
Format:Häftad
Språk:Engelska
Antal sidor:156
Förlag:Springer-Verlag New York Inc.
ISBN:9781461347668

Utforska kategorier

Cellbiologi inom Naturvetenskap och teknik
Geriatrik inom Medicin
Biovetenskap inom Naturvetenskap och teknik

Innehållsförteckning

1. Clinical Aspects of Werner’s Syndrome: Its Natural History and the Genetics of the Disease.- 2. Biochemical Roles of RecQ Helicases.- 3. Biochemical Characterization of the Werner Syndrome DNA Helicase-Exonuclease.- 4. Proteins That Interact with the Werner Syndrome Gene Product.- 5. Sensitivity of Werner’s Syndrome Cells to DNA Damaging Agents: Insights into the Biological Functions of the Werner Protein.- 6. Yeast RecQHelicases: Clues to DNA Repair, Genome Stability and Aging.- 7. Potential Function of the Werner’s Syndrome Homologue in the African Clawed Frog and the Mouse.- 8. Proposed Biological Functions for the Werner Syndrome Protein in DNA Metabolism.- Replicative Senescence, Telomeres and Werner’s Syndrome.