To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.
1. Clinical Aspects of Werner’s Syndrome: Its Natural History and the Genetics of the Disease.- 2. Biochemical Roles of RecQ Helicases.- 3. Biochemical Characterization of the Werner Syndrome DNA Helicase-Exonuclease.- 4. Proteins That Interact with the Werner Syndrome Gene Product.- 5. Sensitivity of Werner’s Syndrome Cells to DNA Damaging Agents: Insights into the Biological Functions of the Werner Protein.- 6. Yeast RecQHelicases: Clues to DNA Repair, Genome Stability and Aging.- 7. Potential Function of the Werner’s Syndrome Homologue in the African Clawed Frog and the Mouse.- 8. Proposed Biological Functions for the Werner Syndrome Protein in DNA Metabolism.- Replicative Senescence, Telomeres and Werner’s Syndrome.
