Molecular Determinants of Radiation Response

Häftad, Engelska, 2013

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Beskrivning

Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury. Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.

Produktinformation

Utgivningsdatum:2013-04-19
Mått:155 x 235 x 16 mm
Vikt:446 g
Format:Häftad
Språk:Engelska
Serie:Current Cancer Research
Antal sidor:276
Upplaga:2011
Förlag:Springer-Verlag New York Inc.
ISBN:9781461428329

Utforska kategorier

Onkologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin

Innehållsförteckning

Molecular Basis of the DNA Damage Responses.- ATM signaling and DNA Damage.- H2AX in DNA Damage Response.- Dynamic Imaging of DNA Damage Foci.- DNA Damage Signaling Downstream of ATM.- Checkpoint Control and Radiation.- Chromatin Responses to DNA Damage.-DNA Damage Response and Senescence.- C. elegans and DNA Damage.- Modulation of Radiation Responses – Opportunities for Therapeutic Exploitation.- The Stem Cell and Radiation.- Role of the Cell Membrane in Signaling Radiation Injury.- Hypoxia and Modulation of Cellular Radiation Response.- Role of PARP and PARP Inhibition in Cellular Response to Radiation.- Anti-angiogenic Therapies and Radiation Responses.- Gene Therapy and Radiation.- Radiation-mediated Molecular Targeting.- EGFR Signaling and Radiation.- Heat and Heat Shock Proteins Modulation of Radiation Response.- Radiation-induced Immune Modulation.