This symposium was organized at the B.M. Birla Science Centre, Hyderabad, India, and provided a platform for frontier physicists to exchange ideas and review the latest work and developments on a variety of interrelated topics. A feature of the symposium, as well as the proceedings, is the B.M. Birla Memorial Lecture by Nobel Laureate Professor Gerard ''t Hooft. There were participants from the USA, several European countries, Russia and CIS countries, South Africa, Japan, India and elsewhere, of whom some forty scientists presented papers. Spanning a wide range of contemporary issues in fundamental physics from string theory to cosmology, the proceedings present many of these talks and contributions.