These notes were developed as a synopsis of general and systemic pathology in order to present to those students who are preparing for national examinations a relatively concise review of the discipline. These notes are not intended to replace the many fine textbooks of pathology whose scope, detail, and mission are more suited to the in-depth study of pathology. Rather, these notes are in­ tended to serve as "memory joggers" to rekindle and refresh the recall of salient features of various disease processes and to point out to the student possible areas of weakness which they may need to address in more detail by referring to one of the standard textbooks of pathology. Hopefully, the notes will allow a systematic review of the material in a rea­ sonable amount of time. Some major topics in Pathology (genetic diseases, im­ munologic disorders, and infectious diseases) are covered in other areas of our curriculum and are therefore not included in an organized fashion in these notes.