Foreword by Albert D. Fraser "This is a very useful and timely book in addiction medicine...This book details the use of buprenorphine with its risks and benefits. It draws extensively from available studies and literature, which are listed very clearly in tables. Some of the appendixes are especially useful for quick references. This is a very useful and easy to read book. It details the use of buprenorphine therapy as an alternate to methadone treatment. It also details the analytical advances in testing for buprenorphines. The book describes buprenorphine's pharmacology and current prescription practices in France. It also discusses the use of buprenorphine in various scenarios including in pregnant addicts, and provides a source of knowledge for everyone working in addiction medicine."-Doody's Health Sciences Book Review Journal "This is a further volume in the growing Forensic medicine and Science Series edited by Steve Karch. This impressive series embraces a range of forensic topics. The style is now familiar, good topic editors with a broad spectrum of specialist authors contributing within their own area of expertise...good topic editors with a broad spectrum of specialist authors contributing within their own area of expertise...worthwhile reading for anyone in contact with patients who are opiate addicted." - Nil Aggrawal's Internet Journal of Forensic Medicine and Toxicology

• 1 Pharmacology of High-Dose Buprenorphine.- 1. Introduction.- 2. Pharmacokinetic Properties.- 3. Pharmacodynamic Properties.- 4. Administration Schedules.- 5. Clinical Effects of Buprenorphine.- 6. Conclusion.- References.- 2 Controlled Drug Administration Studies of High-Dose Buprenorphine in Humans.- 1. Introduction.- 2. Bioavailability.- 3. Dose-Effect Profiles.- 4. Abuse Liability.- 5. Toxicity.- 6. Safety and Abuse Liability of High-Dose Intravenous Buprenorphine.- 7. Conclusion.- References.- 3 High-Dose Buprenorphine for Treatment of Opioid Dependence.- 1. Introduction.- 2. Buprenorphine Solution vs Tablets.- 3. Efficacy of Buprenorphine vs Placebo: Clinical Trials.- 4. Efficacy of Buprenorphine vs Other Medications: Clinical Trials.- 5. Safety and Side Effects of Buprenorphine.- 6. Summary and Conclusions.- Acknowledgment.- References.- 4 Foreseeable Advantages and Limits of Buprenorphine-Naloxone Association.- 1. Introduction.- 2. Advantages of Buprenorphine-Naloxone Association.- 2.1.1. Epidemic of Pentazocine and Tripelennamine Abuse in the United States.- 2.1.2. Epidemic of Analgesic Buprenorphine Abuse in New Zealand.- 3. Limits of Buprenorphine-Naloxone Association.- 4. Conclusion.- References.- 5 Buprenorphine Maintenance Treatment in Primary Care: An Overview of the French Experience and Insight Into the Prison Setting.- 1. Introduction.- 2. Implementation of BMT Through French Primary Care System.- 3. Observable Effects of French Policy.- 4. Prison.- 5. Conclusion.- Acknowledgments.- References.- 6 Buprenorphine as a Viable Pharmacotherapy in Australia.- 1. Introduction.- 2. Buprenorphine.- 3. National Evaluation of Pharmacotherapies for Opioid Dependence.- 4. Conclusion.- Acknowledgments.- References.- 7 Separative Techniques for Determination of Buprenorphine.- 1. Introduction.- 2. Determination of Buprenorphine in Blood.- 3. Determination of Buprenorphine in Urine.- 4. Determination of Buprenorphine in Biological Tissues.- 5. Determination of Buprenorphine in Hair.- 6. Conclusion.- References.- 8 Buprenorphine-Related Deaths.- 1. Introduction.- 2. Forensic Aspects.- 3. Buprenorphine Fatalities.- 4. Conclusion.- References.- 9 Pharmacology of Opiates During Pregnancy and in Neonates.- 1. Introduction.- 2. Perinatal Pharmacokinetics of Opiates.- 3. Perinatal Pharmacodynamics of Opiates.- 4. Maintenance Treatments During Pregnancy.- References.- 10 Case Study of Neonates Born to Mothers Undergoing Buprenorphine Maintenance Treatment.- 1. Introduction.- 2. Clinical Findings.- 3. Toxicological Investigations.- 4. Discussion.- 5. Conclusion.- Acknowledgments.- References.- 11 Buprenorphine and Pregnancy: A Comparative, Multicenter Clinical Study of High-Dose Buprenorphine vs Methadone Maintenance.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- 5. Conclusion.- Acknowledgments.- References.

Foreword by Albert D. Fraser "This is a very useful and timely book in addiction medicine...This book details the use of buprenorphine with its risks and benefits. It draws extensively from available studies and literature, which are listed very clearly in tables. Some of the appendixes are especially useful for quick references. This is a very useful and easy to read book. It details the use of buprenorphine therapy as an alternate to methadone treatment. It also details the analytical advances in testing for buprenorphines. The book describes buprenorphine's pharmacology and current prescription practices in France. It also discusses the use of buprenorphine in various scenarios including in pregnant addicts, and provides a source of knowledge for everyone working in addiction medicine."-Doody's Health Sciences Book Review Journal "This is a further volume in the growing Forensic medicine and Science Series edited by Steve Karch. This impressive series embraces a range of forensic topics. The style is now familiar, good topic editors with a broad spectrum of specialist authors contributing within their own area of expertise...good topic editors with a broad spectrum of specialist authors contributing within their own area of expertise...worthwhile reading for anyone in contact with patients who are opiate addicted." - Nil Aggrawal's Internet Journal of Forensic Medicine and Toxicology

• 1 Pharmacology of High-Dose Buprenorphine.- 1. Introduction.- 2. Pharmacokinetic Properties.- 3. Pharmacodynamic Properties.- 4. Administration Schedules.- 5. Clinical Effects of Buprenorphine.- 6. Conclusion.- References.- 2 Controlled Drug Administration Studies of High-Dose Buprenorphine in Humans.- 1. Introduction.- 2. Bioavailability.- 3. Dose-Effect Profiles.- 4. Abuse Liability.- 5. Toxicity.- 6. Safety and Abuse Liability of High-Dose Intravenous Buprenorphine.- 7. Conclusion.- References.- 3 High-Dose Buprenorphine for Treatment of Opioid Dependence.- 1. Introduction.- 2. Buprenorphine Solution vs Tablets.- 3. Efficacy of Buprenorphine vs Placebo: Clinical Trials.- 4. Efficacy of Buprenorphine vs Other Medications: Clinical Trials.- 5. Safety and Side Effects of Buprenorphine.- 6. Summary and Conclusions.- Acknowledgment.- References.- 4 Foreseeable Advantages and Limits of Buprenorphine-Naloxone Association.- 1. Introduction.- 2. Advantages of Buprenorphine-Naloxone Association.- 2.1.1. Epidemic of Pentazocine and Tripelennamine Abuse in the United States.- 2.1.2. Epidemic of Analgesic Buprenorphine Abuse in New Zealand.- 3. Limits of Buprenorphine-Naloxone Association.- 4. Conclusion.- References.- 5 Buprenorphine Maintenance Treatment in Primary Care: An Overview of the French Experience and Insight Into the Prison Setting.- 1. Introduction.- 2. Implementation of BMT Through French Primary Care System.- 3. Observable Effects of French Policy.- 4. Prison.- 5. Conclusion.- Acknowledgments.- References.- 6 Buprenorphine as a Viable Pharmacotherapy in Australia.- 1. Introduction.- 2. Buprenorphine.- 3. National Evaluation of Pharmacotherapies for Opioid Dependence.- 4. Conclusion.- Acknowledgments.- References.- 7 Separative Techniques for Determination of Buprenorphine.- 1. Introduction.- 2. Determination of Buprenorphine in Blood.- 3. Determination of Buprenorphine in Urine.- 4. Determination of Buprenorphine in Biological Tissues.- 5. Determination of Buprenorphine in Hair.- 6. Conclusion.- References.- 8 Buprenorphine-Related Deaths.- 1. Introduction.- 2. Forensic Aspects.- 3. Buprenorphine Fatalities.- 4. Conclusion.- References.- 9 Pharmacology of Opiates During Pregnancy and in Neonates.- 1. Introduction.- 2. Perinatal Pharmacokinetics of Opiates.- 3. Perinatal Pharmacodynamics of Opiates.- 4. Maintenance Treatments During Pregnancy.- References.- 10 Case Study of Neonates Born to Mothers Undergoing Buprenorphine Maintenance Treatment.- 1. Introduction.- 2. Clinical Findings.- 3. Toxicological Investigations.- 4. Discussion.- 5. Conclusion.- Acknowledgments.- References.- 11 Buprenorphine and Pregnancy: A Comparative, Multicenter Clinical Study of High-Dose Buprenorphine vs Methadone Maintenance.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- 5. Conclusion.- Acknowledgments.- References.

Foreword by Albert D. Fraser "This is a very useful and timely book in addiction medicine...This book details the use of buprenorphine with its risks and benefits. It draws extensively from available studies and literature, which are listed very clearly in tables. Some of the appendixes are especially useful for quick references. This is a very useful and easy to read book. It details the use of buprenorphine therapy as an alternate to methadone treatment. It also details the analytical advances in testing for buprenorphines. The book describes buprenorphine's pharmacology and current prescription practices in France. It also discusses the use of buprenorphine in various scenarios including in pregnant addicts, and provides a source of knowledge for everyone working in addiction medicine."-Doody's Health Sciences Book Review Journal "This is a further volume in the growing Forensic medicine and Science Series edited by Steve Karch. This impressive series embraces a range of forensic topics. The style is now familiar, good topic editors with a broad spectrum of specialist authors contributing within their own area of expertise...good topic editors with a broad spectrum of specialist authors contributing within their own area of expertise...worthwhile reading for anyone in contact with patients who are opiate addicted." - Nil Aggrawal's Internet Journal of Forensic Medicine and Toxicology

• 1 Pharmacology of High-Dose Buprenorphine.- 1. Introduction.- 2. Pharmacokinetic Properties.- 3. Pharmacodynamic Properties.- 4. Administration Schedules.- 5. Clinical Effects of Buprenorphine.- 6. Conclusion.- References.- 2 Controlled Drug Administration Studies of High-Dose Buprenorphine in Humans.- 1. Introduction.- 2. Bioavailability.- 3. Dose-Effect Profiles.- 4. Abuse Liability.- 5. Toxicity.- 6. Safety and Abuse Liability of High-Dose Intravenous Buprenorphine.- 7. Conclusion.- References.- 3 High-Dose Buprenorphine for Treatment of Opioid Dependence.- 1. Introduction.- 2. Buprenorphine Solution vs Tablets.- 3. Efficacy of Buprenorphine vs Placebo: Clinical Trials.- 4. Efficacy of Buprenorphine vs Other Medications: Clinical Trials.- 5. Safety and Side Effects of Buprenorphine.- 6. Summary and Conclusions.- Acknowledgment.- References.- 4 Foreseeable Advantages and Limits of Buprenorphine-Naloxone Association.- 1. Introduction.- 2. Advantages of Buprenorphine-Naloxone Association.- 2.1.1. Epidemic of Pentazocine and Tripelennamine Abuse in the United States.- 2.1.2. Epidemic of Analgesic Buprenorphine Abuse in New Zealand.- 3. Limits of Buprenorphine-Naloxone Association.- 4. Conclusion.- References.- 5 Buprenorphine Maintenance Treatment in Primary Care: An Overview of the French Experience and Insight Into the Prison Setting.- 1. Introduction.- 2. Implementation of BMT Through French Primary Care System.- 3. Observable Effects of French Policy.- 4. Prison.- 5. Conclusion.- Acknowledgments.- References.- 6 Buprenorphine as a Viable Pharmacotherapy in Australia.- 1. Introduction.- 2. Buprenorphine.- 3. National Evaluation of Pharmacotherapies for Opioid Dependence.- 4. Conclusion.- Acknowledgments.- References.- 7 Separative Techniques for Determination of Buprenorphine.- 1. Introduction.- 2. Determination of Buprenorphine in Blood.- 3. Determination of Buprenorphine in Urine.- 4. Determination of Buprenorphine in Biological Tissues.- 5. Determination of Buprenorphine in Hair.- 6. Conclusion.- References.- 8 Buprenorphine-Related Deaths.- 1. Introduction.- 2. Forensic Aspects.- 3. Buprenorphine Fatalities.- 4. Conclusion.- References.- 9 Pharmacology of Opiates During Pregnancy and in Neonates.- 1. Introduction.- 2. Perinatal Pharmacokinetics of Opiates.- 3. Perinatal Pharmacodynamics of Opiates.- 4. Maintenance Treatments During Pregnancy.- References.- 10 Case Study of Neonates Born to Mothers Undergoing Buprenorphine Maintenance Treatment.- 1. Introduction.- 2. Clinical Findings.- 3. Toxicological Investigations.- 4. Discussion.- 5. Conclusion.- Acknowledgments.- References.- 11 Buprenorphine and Pregnancy: A Comparative, Multicenter Clinical Study of High-Dose Buprenorphine vs Methadone Maintenance.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- 5. Conclusion.- Acknowledgments.- References.