Endocrinology of Breast Cancer

"A variety of topics are covered, including carcinogenesis, tumor progression, therapeutic options, and benign breast disease. The section divisions of the book make it easy to locate topics of interest. Each chapter has an extensive list of references for further study. Parts IV and V are very thorough in reviewing targets for therapy and endocrine therapy. These chapters provide a good basis from which to understand the development of endocrine therapies. The discussion of normal breast physiology and development is beneficial for the less specialized physician and helps to round out the discussion. "-Doody's Health Science Book Review Journal "...an invaluable resource for both basic scientists and clinicians who need to update their knowledge about breast cancer biology..."-Cell Biology International 2000 "The authors have succeeded in exploring the most important cell physiology and molecular biology issues pertaining to m endocrinology of breast cancer. For example, there are detailed chapters exploring the relationship between both oncogenes and tumor suppressor genes and breast cancer induction and progression. In addition this volume contains detailed, yet concise, chapters pertaining to the prediction of breast cancer, chemoprevention, and the most novel hormonal treatment strategies. The editor and the authors have clearly worked together to create a focused, yet thorough chapters with minimal overlap, and maximum synergy among chapters" -Quarterly Review of Biology "...will serve as a comprehensive reference for students, physicians in training, practitioners and investigators...I found the book most helpful as an encyclopedia description of the subject matter. ...I give DR. Manni high marks for having pulled it all together. The goal was to furnish a new state-of-the-art, reference text to fill an important gap." -Elsevier Science "If you are very interested in the endocrinology of breast development and disease, there probably is no other book available that deals with this area as completely and as currently as this one. Thus, it is a significant contribution to the breast literature."-Modern Pathology

• I Hormonal Control of Mammary Development and Growth.- 1 Hormonal Control of Normal Breast Morphology and Function.- 2 Interactions Between Estradiol and Progesterone in Normal Breast: Implications for Mammary Carcinogenesis.- 3 Expression and Regulation of Insulin-like Growth Factors and Their Binding Proteins in the Normal Breast.- II Carcinogenesis.- 4 Estrogens and Breast Cancer: An Epidemiologic Perspective.- 5 Androgens, Estrogens, and Breast Cancer Risk.- 6 Local Estrogen Production: Is Aromatase An Oncogene?.- 7 Oncogenes and Mammary Carcinogenesis.- 8 Categorization of Breast Cyst Fluid and Breast Cancer Risk.- III Tumor Progression.- 9 The Role of Tumor Suppressor Genes in Breast Cancer Progression.- 10 Oncogene Activation and Breast Cancer Progression.- 11 Interactions Between Stroma and Epithelium in Breast Cancer: Implications for Tumor Genesis, Growth, and Progression.- 12 The Role of Angiogenesis in the Transition to Hormone Independence and Acquisition of the Metastatic Phenotype.- 13 Role of the IGF System in Breast Cancer Proliferation and Progression.- 14 Prognostic and Predictive Factors in Breast Cancer.- 15 Role of the Polyamine Pathway in the Natural History of Breast Cancer.- IV Estrogen, Progestins, and Prolactin in Breast Cancer Biology: Targets for Treatment.- 16 Aromatase Inhibitors in Breast Carcinoma.- 17 Role of Progestins and Progesterone Receptors in Breast Cancer Biology.- 18 Prolactin and its Receptors in Human Breast Cancer.- V Endocrine Therapy of Breast Cancer.- 19 Pharmacology and Use of Antiestrogens in Treatment and Chemoprevention of Breast Cancer.- 20 LHRH Superagonists and Antagonists in the Treatment of Breast Cancer.- VI Benign Breast Disease.- 21 Benign Breast Lesions: Pathologic Classification and Risk Potential.- 22 Hormonal Treatment of Fibrocystic Disease.- 23 Gynecomastia and Galactorrhea.