Complement System

Novel Roles in Health and Disease

Häftad, Engelska, 2013

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As a phylogenetically old system complement is now regarded as a part of innate immunity.

The Development of the “One-Hit” or “Single Site” Theory of Complement Mediated Immune Hemolysis.- The Initiation Complexes of the Classical and Lectin Pathways.- Complement Genetics.- Regulation of Complement Receptor Gene Expression.- Coordination of Adaptive Immune Responses by C3.- Terminal Complement Complex: Regulation of Formation and Pathophysiological Functions.- The Many Faces of the Membrane Regulators of Complement.- New Insights into the Regulation of Complement Activation by Decay Accelerating Factor.- The Role of Complement in Pregnancy and Fetal Loss.- Complement Deficiencies: a 2004 Update.- Microbial Evasion Mechanisms Against Human Complement.- Complement-Mediated Antibody-Dependent Enhancement of Viral Infections.- Tumor Cell Resistance to Complement-Mediated Lysis.- Complement and Autoimmunity.- The Complex Roles of Anaphylatoxins in Allergic Asthma and Autoimmune Diseases.- Role of Complement in Allergy.- Complement Activation-Related Pseudoallergy.- The Role of Complement in Transplantation.- Role of Complement in Myocardial Ischemia and Infarction.- Role of Complement in Intestinal Ischemia/Reperfusion Induced Injury.- Role of C5a and C5a Receptor in Sepsis.- Role of Complement in Multi-Organ Dysfunction Syndrome.- Therapeutic Manipulation of the Complement System.- Activation and Inhibition of Complement by Immunoglobulins.- Engineering Control of Complement Inhibition at the Cell Surface.