Janos Szebeni – författare

The Complement System: Novel Roles in Health and Disease surveys the advances in basic and applied research on the complement system over the past few years. Complement is a major protein network in blood that has been traditionally conceived as part of the immune system, a proinflammatory cascade engaged in nonspecific antimicrobial defence. However, it became clear recently that this system also plays an essential role in specific, adaptive immune responses, as well as in many basic physiological processes including cardiovascular regulation, pregnancy and tissue regeneration, just to mention a few. Complement proteins are widely involved in the immune evasion tactics of infectious microbes and cancer cells, and derangement of complement function contributes to numerous autoimmune, allergic and acute catastrophic diseases. Because pharmacological manipulation of the complement system provides therapeutic benefit in many of these conditions, we may be very close to widespread clinical use of a new class of drugs influencing complement activation or action. In fact, complementology may be one of the most versatile and dynamic subdisciplines in medicine today.The 25 reviews of this volume, written by prominent experts, provide state-of-art insights into the various aspects of an amazing progress in this field. This comprehensive, up-to-date volume represents a rich resource on the complement system and it will be an invaluable resource for physicians, immunologists and biologists. Researchers, educators and students in the areas of internal medicine, immunology, allergies, infectious disease and rheumatology will have a resource that is state-of the-art. This new and up-to-date book on the complement system presents and discusses the advances that have been made in recent years in the understanding of the roles of the system in the maintenance of health and its participation in pathology. The chapters from prominent experts cover the essentials as well as the hottest issues in complementology. The topics are ordered in increasing complexity from basic molecular to human clinical, building the case for the ultimate message: time has come to find new ways to modulate the system in-vivo in order to make better use of its protective powers and to prevent its adverse effects in disease. I am certain that this book will forward these goals.Otto Gotze, Emeritus Professor of Immunology, University of Gottingen

The Complement System: Novel Roles in Health and Disease surveys the advances in basic and applied research on the complement system over the past few years. Complement is a major protein network in blood that has been traditionally conceived as part of the immune system, a proinflammatory cascade engaged in nonspecific antimicrobial defence. However, it became clear recently that this system also plays an essential role in specific, adaptive immune responses, as well as in many basic physiological processes including cardiovascular regulation, pregnancy and tissue regeneration, just to mention a few. Complement proteins are widely involved in the immune evasion tactics of infectious microbes and cancer cells, and derangement of complement function contributes to numerous autoimmune, allergic and acute catastrophic diseases. Because pharmacological manipulation of the complement system provides therapeutic benefit in many of these conditions, we may be very close to widespread clinical use of a new class of drugs influencing complement activation or action. In fact, complementology may be one of the most versatile and dynamic subdisciplines in medicine today.The 25 reviews of this volume, written by prominent experts, provide state-of-art insights into the various aspects of an amazing progress in this field. This comprehensive, up-to-date volume represents a rich resource on the complement system and it will be an invaluable resource for physicians, immunologists and biologists. Researchers, educators and students in the areas of internal medicine, immunology, allergies, infectious disease and rheumatology will have a resource that is state-of the-art. This new and up-to-date book on the complement system presents and discusses the advances that have been made in recent years in the understanding of the roles of the system in the maintenance of health and its participation in pathology. The chapters from prominent experts cover the essentials as well as the hottest issues in complementology. The topics are ordered in increasing complexity from basic molecular to human clinical, building the case for the ultimate message: time has come to find new ways to modulate the system in-vivo in order to make better use of its protective powers and to prevent its adverse effects in disease. I am certain that this book will forward these goals.Otto Gotze, Emeritus Professor of Immunology, University of Gottingen

As a phylogenetically old system complement is now regarded as a part of innate immunity. But it is much more than that. It bridges innate and adapted immunity, participates not only in host defense but also in many essential physiological processes, old and new diseases and adverse conditions. Indeed, complement became a term that almost defies categorization. What was for a long time a subject for a limited number of specialists has now moved into the mainstream of experimental and clinical immunology. In 1973 I visited the Basel Institute of Immunology and met its director, the eminent scientist and Nobel laureate Nils Jerne. When I entered his office he greeted me with the following words: “Complement, does that really exist?” I was never certain whether he wanted only to tease me or whether he sincerely believed that the complement system was an unimportant biological curiosity, a misstep of evolution. But, of course, missteps do not survive the evolutionary process. Little did I foresee the dramatic developments of recent years when Hans J. Müller-Eberhard and I started to unravel the specifics of the action of the cobra venom factor on the complement system in 1968 and defined a new pathway to its activation. An elucidation of the role of the system in diseases and its control for therapeutic reasons is now getting closer to actual realization in the clinic although many problems, in particular those of highly specificinhibition free of side effects, have still to be resolved.