Vaccine Design

Methods and Protocols: Volume 1: Vaccines for Human Diseases

AvSunil Thomas

Häftad, Engelska, 2018

Del i serien Methods in Molecular Biology

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Beskrivning

This text provides a practical guide providing step-by-step protocol to design and develop vaccines. The design of human vaccines for viral, bacterial, fungal, parasitic and prion diseases as well as vaccines for drug abuse, allergy, and tumor vaccines are also described in this volume.

Produktinformation

Utgivningsdatum:2018-04-19
Mått:178 x 254 x 48 mm
Vikt:1 649 g
Format:Häftad
Språk:Engelska
Serie:Methods in Molecular Biology
Antal sidor:873
Förlag:Humana Press Inc.
ISBN:9781493980383

Utforska kategorier

Infektionssjukdomar och smittsamma sjukdomar inom Medicin
Onkologi inom Medicin

Innehållsförteckning

Clinical Impact of Vaccine Development.- Future Challenges for Vaccinologists.- Principles of Vaccination.- Reverse Vaccinology: The Pathway from Genomes and Epitope Predictions to Tailored Recombinant Vaccines.- Systems Vaccinology: Applications, Trends, and Perspectives.- Proteomic Monitoring of B Cell Immunity.- Development of Rabies Virus-Like Particles for Vaccine Applications: Production, Characterization and Protection Studies.- Analytic Vaccinology: Antibody-Driven Design of a Human Cytomegalovirus Subunit Vaccine.- Generation of a Single-Cycle Replicable Rift Valley Fever Vaccine.- Application of Droplet Digital PCR to Validate Rift Valley Fever Vaccines.- Methods to Evaluate Novel Hepatitis C Virus Vaccines.- Designing Efficacious Vesicular Stomatitis Virus-Vectored Vaccines against Ebola Virus.- Assessment of Functional Norovirus Antibody Responses by Blocking Assay in Mice.- Development of a SARS Coronavirus Vaccine from Recombinant Spike Protein plus Delta Inulin Adjuvant.- Generation and Characterization of a Chimeric Tick-Borne Encephalitis Virus Attenuated Strain ChinTBEV.- Single-Vector, Single-injection Recombinant Vesicular Stomatitis Virus Vaccines against High Containment Viruses.- Reverse Genetics Approaches to Control Arenavirus.- DNA Vaccines: A Strategy for Developing Novel Multivalent TB Vaccines.- Overcoming Enterotoxigenic Escherichia coli Pathogen Diversity: Translational Molecular Approaches to Inform Vaccine Design.- Design and Purification of Subunit Vaccines for Prevention of Clostridium difficile Infection.- The Design of a Clostridium difficile Carbohydrate-based Vaccine.- Murine Models of Bacteremia and Surgical Wound Infection for the Evaluation of Staphylococcus aureus Vaccine Candidates.- Using MHC Molecules to define a Chlamydia T Cell Vaccine .- An Approach to Identify and Characterize a Subunit Candidate Shigella Vaccine Antigen.- Approach to the Discovery, Development and Evaluation of a Novel Neisseria meningitidis Serogroup B Vaccine.- Anti-Lyme Subunit Vaccines: Design and Development of Peptide-based Vaccine Candidates.- Assessment of Live Plague Vaccine Candidates.- Highly Effective Soluble and Bacteriophage T4 Nanoparticle Plague Vaccines against Yersinia pestis.- Development of Structure-based Vaccines for Ehrlichiosis.- Dendritic Cell-based Vaccine against Fungal Infection.- Flow Cytometric Analysis of Protective T-cell Response against Pulmonary Coccidioides Infection.- High-Density Peptide Arrays for Malaria Vaccine Development.- Development and Assessment of Transgenic Rodent Parasites for the Pre-clinical Evaluation of Malaria Vaccines.- DNA Integration in Leishmania Genome: an Application for Vaccine Development and Drug Screening.- Methods to Evaluate the Preclinical Safety and Immunogenicity of Genetically Modified Live Attenuated Leishmania Parasite Vaccines.- The Use of Microwave Assisted Solid Phase Peptide Synthesisand Click Chemistry for the Synthesis of Vaccine Candidates against Hookworm Infection.- Methods and Protocols for Developing Prion Vaccines.- Ricin-Holotoxin Based Vaccines: Induction of Potent Ricin Neutralizing Antibodies.- Synthesis of Hapten-protein Conjugate Vaccines with Reproducible Hapten Densities.- Production of Rice Seed-based Allergy Vaccines.- Allergy Vaccines Using a Mycobacterium-Secreted Antigen, Ag85B, and an IL-4 Antagonist.- Development of House Dust Mite Vaccine.- Cancer Vaccines: A Brief Overview.- Dendritic Cell Vaccines.- Peptide-based Cancer Vaccine Strategies and Clinical Results.- Preconditioning Vaccine Sites for mRNA--Transfected Dendritic Cell Therapy and Antitumor Efficacy.- Development of Antibody based Vaccines Targeting the Tumor Vasculature.