Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.
"This is a very complete book on modeling the pharmacokinetics of drugs. . . It is one of the very few advanced texts in the field, written by one of the founders of the field and is written with a distilled insight that can only be obtained from years of experience in the field. I highly recommend it."--Elke Lipka for Pharmaceutical News
Innehållsförteckning
Simple Linear ModelsMore Complicated Linear ModelsComplicated Linear ModelsLinear Multicompartment Disposition Parameters from Extravascular DownslopeC,T DataNoncompartmental and System Analysis Linear Multiple Dose EquationsSimple Nonlinear ModelsMore Complicated Nonlinear ModelsUrinary ExcretionAbsorption Analysis and BioavailabilityPhysiological PharmacokineticsRelationship between Physiologically Based Flow Models and Usual CompartmentModelsProtein BindingPharmacokineticPharmacodynamic ModellingMetabolic KineticsLaplace Derivation of Linear Pharmacokinetic EquationsMeasures of FitAppendixIndex175 Figures and Schematics, 51 Tables, 134 References
