Wolfram W. Domschke and Martin F Kagnoff are the authors of Inflammatory Bowel Disease: Genetics, Barrier Function, and Immunological Mechanisms, and Microbial Pathways, Volume 1072, published by Wiley.

• Introduction: Current Limitations of IBD Treatment. Where Do We Go From Here?: S.R. Targan.Part I: Genetics of Inflammatory Bowel Disease –NOD/CARD Proteins: Diagnostic and Therapeutic Consequences?:.1. Microbial Signaling Through NOD Proteins: D. Philpott.2. NOD2/CARD Mutations in Crohn’s Disease: J.P. Hugot.3. Functional Relevance of NOD2 On Cellular Signalling in Crohn's Disease: G. Nunez.4. Do Genetic Mutations Provide New Insights for Therapy?: J. Cho.Part II: Immunologic Abnormalities in IBD – What Can We Learn From Animal Models?:.5. Role of TGFβ in Mucosal Inflammation: W. Strober.6. TNF/TNFR-Pathways in Chronic Inflammation: G. Kollias.7. Lessons From Enteric Infections: L. Eckmann.8. New Insights From Studies of Regulatory T Cell Populations: A. O'Garra.9. the Commensal Microbial Flora: Relevance for Intestinal Inflammation: C.O. Elson.Part III: Immunologic Disturbances in Human IBD – Defining and Manipulating the Key Pathways:.10. Chemokines and Cell Trafficking Within the Inflamed Mucosa -- Inhibition of Chemokine Receptors or Ligands as a Potential Approach for Treatment?: I.R. Williams.11. Life and Death – the Role of Apoptosis: T. Kucharzik.12. Cytokines – Who Are the Key Plays and the Role for Cytokine Treatment: R.S. Blumberg.13. Novel Signal Transduction Pathways – Relevance for Future Therapies?: M.F. Neurath.14. NF-Kappa-B Signaling –the Pros and Cons of Altering NF-κB as a Therapeutic Approach: M. Karin.15. Intracellular Targets: a Role for Inhibition of MAP-Kinases in Therapy?: S.J. Deventer.16. Leucocyte Adhesion Molecules – Are They Relevant as Target for IBD Treatment?: D.B. Binion.Part IV: Intestinal Epithelial Cells in IBD - An Active Barrier?:.17. Tight Junction Function and the Modulation of Paracellular Permeability During IBD: a. Nusrat.18. Epithelial Transport Under Inflammatory Conditions – Can It Be Regulated?: M.C. Berin.19. Imbalance of Epithelial Electrolyte Homeostasis – Role in the Pathophysiology of IBD: U. Seidler.20. Neutrophil Transepithelial Migration and Epithelial Barrier Function in IBD – Potential Targets for Inhibiting Neutrophil Trafficking: C.A. Parkos.Part V: GALT – Relevant for Regulation of Inflammation?:.21. Collaboration of Epithelial Cells With Organized Lymphoid Tissue: M.J. Kraehenbuhl.22. Role of Lymphotoxins in the Development of PP and MLN – Relevance to Intestinal Inflammation and Treatment: T.W. Spahn.23. Trafficking and Function of Mucosal Dendritic Cells: A. Iwasaki.24. Intraepithelial T-Cells – Implication for Intestinal Inflammation: M. Kronenberg.Part VI: Relevance of Microbial Factors – Additive Or Causative for IBD?:.25. Microbial – Epithelial Cell Crosstalk During Inflammation: The Host Response: M. Kagnoff.26. Role of Toll-Like Receptors in Orchestrating the Innate Immune Response – Potential Targets for Treatment?: D. Podolsky.27. Host-Bacterial Interactions in the Gut: Signalling by Commensal Flora: J. Gordon.28. Immunostimulatory DNA- Potential Therapeutics for Treatment of Enteric Inflammatory Disease?: E. Raz.29. Probiotics – Their Role in Controlling Intestinal Inflammation?: J.F. Colombel.30. Inflammatory Bowel Disease – Pandora's Box, Present and Future: J. Schölmerich.Index of Contributors

Wolfram W. Domschke and Martin F Kagnoff are the authors of Inflammatory Bowel Disease: Genetics, Barrier Function, and Immunological Mechanisms, and Microbial Pathways, Volume 1072, published by Wiley.

• Introduction: Current Limitations of IBD Treatment. Where Do We Go From Here?: S.R. Targan.Part I: Genetics of Inflammatory Bowel Disease –NOD/CARD Proteins: Diagnostic and Therapeutic Consequences?:.1. Microbial Signaling Through NOD Proteins: D. Philpott.2. NOD2/CARD Mutations in Crohn’s Disease: J.P. Hugot.3. Functional Relevance of NOD2 On Cellular Signalling in Crohn's Disease: G. Nunez.4. Do Genetic Mutations Provide New Insights for Therapy?: J. Cho.Part II: Immunologic Abnormalities in IBD – What Can We Learn From Animal Models?:.5. Role of TGFβ in Mucosal Inflammation: W. Strober.6. TNF/TNFR-Pathways in Chronic Inflammation: G. Kollias.7. Lessons From Enteric Infections: L. Eckmann.8. New Insights From Studies of Regulatory T Cell Populations: A. O'Garra.9. the Commensal Microbial Flora: Relevance for Intestinal Inflammation: C.O. Elson.Part III: Immunologic Disturbances in Human IBD – Defining and Manipulating the Key Pathways:.10. Chemokines and Cell Trafficking Within the Inflamed Mucosa -- Inhibition of Chemokine Receptors or Ligands as a Potential Approach for Treatment?: I.R. Williams.11. Life and Death – the Role of Apoptosis: T. Kucharzik.12. Cytokines – Who Are the Key Plays and the Role for Cytokine Treatment: R.S. Blumberg.13. Novel Signal Transduction Pathways – Relevance for Future Therapies?: M.F. Neurath.14. NF-Kappa-B Signaling –the Pros and Cons of Altering NF-κB as a Therapeutic Approach: M. Karin.15. Intracellular Targets: a Role for Inhibition of MAP-Kinases in Therapy?: S.J. Deventer.16. Leucocyte Adhesion Molecules – Are They Relevant as Target for IBD Treatment?: D.B. Binion.Part IV: Intestinal Epithelial Cells in IBD - An Active Barrier?:.17. Tight Junction Function and the Modulation of Paracellular Permeability During IBD: a. Nusrat.18. Epithelial Transport Under Inflammatory Conditions – Can It Be Regulated?: M.C. Berin.19. Imbalance of Epithelial Electrolyte Homeostasis – Role in the Pathophysiology of IBD: U. Seidler.20. Neutrophil Transepithelial Migration and Epithelial Barrier Function in IBD – Potential Targets for Inhibiting Neutrophil Trafficking: C.A. Parkos.Part V: GALT – Relevant for Regulation of Inflammation?:.21. Collaboration of Epithelial Cells With Organized Lymphoid Tissue: M.J. Kraehenbuhl.22. Role of Lymphotoxins in the Development of PP and MLN – Relevance to Intestinal Inflammation and Treatment: T.W. Spahn.23. Trafficking and Function of Mucosal Dendritic Cells: A. Iwasaki.24. Intraepithelial T-Cells – Implication for Intestinal Inflammation: M. Kronenberg.Part VI: Relevance of Microbial Factors – Additive Or Causative for IBD?:.25. Microbial – Epithelial Cell Crosstalk During Inflammation: The Host Response: M. Kagnoff.26. Role of Toll-Like Receptors in Orchestrating the Innate Immune Response – Potential Targets for Treatment?: D. Podolsky.27. Host-Bacterial Interactions in the Gut: Signalling by Commensal Flora: J. Gordon.28. Immunostimulatory DNA- Potential Therapeutics for Treatment of Enteric Inflammatory Disease?: E. Raz.29. Probiotics – Their Role in Controlling Intestinal Inflammation?: J.F. Colombel.30. Inflammatory Bowel Disease – Pandora's Box, Present and Future: J. Schölmerich.Index of Contributors

Wolfram W. Domschke and Martin F Kagnoff are the authors of Inflammatory Bowel Disease: Genetics, Barrier Function, and Immunological Mechanisms, and Microbial Pathways, Volume 1072, published by Wiley.

• Introduction: Current Limitations of IBD Treatment. Where Do We Go From Here?: S.R. Targan.Part I: Genetics of Inflammatory Bowel Disease –NOD/CARD Proteins: Diagnostic and Therapeutic Consequences?:.1. Microbial Signaling Through NOD Proteins: D. Philpott.2. NOD2/CARD Mutations in Crohn’s Disease: J.P. Hugot.3. Functional Relevance of NOD2 On Cellular Signalling in Crohn's Disease: G. Nunez.4. Do Genetic Mutations Provide New Insights for Therapy?: J. Cho.Part II: Immunologic Abnormalities in IBD – What Can We Learn From Animal Models?:.5. Role of TGFβ in Mucosal Inflammation: W. Strober.6. TNF/TNFR-Pathways in Chronic Inflammation: G. Kollias.7. Lessons From Enteric Infections: L. Eckmann.8. New Insights From Studies of Regulatory T Cell Populations: A. O'Garra.9. the Commensal Microbial Flora: Relevance for Intestinal Inflammation: C.O. Elson.Part III: Immunologic Disturbances in Human IBD – Defining and Manipulating the Key Pathways:.10. Chemokines and Cell Trafficking Within the Inflamed Mucosa -- Inhibition of Chemokine Receptors or Ligands as a Potential Approach for Treatment?: I.R. Williams.11. Life and Death – the Role of Apoptosis: T. Kucharzik.12. Cytokines – Who Are the Key Plays and the Role for Cytokine Treatment: R.S. Blumberg.13. Novel Signal Transduction Pathways – Relevance for Future Therapies?: M.F. Neurath.14. NF-Kappa-B Signaling –the Pros and Cons of Altering NF-κB as a Therapeutic Approach: M. Karin.15. Intracellular Targets: a Role for Inhibition of MAP-Kinases in Therapy?: S.J. Deventer.16. Leucocyte Adhesion Molecules – Are They Relevant as Target for IBD Treatment?: D.B. Binion.Part IV: Intestinal Epithelial Cells in IBD - An Active Barrier?:.17. Tight Junction Function and the Modulation of Paracellular Permeability During IBD: a. Nusrat.18. Epithelial Transport Under Inflammatory Conditions – Can It Be Regulated?: M.C. Berin.19. Imbalance of Epithelial Electrolyte Homeostasis – Role in the Pathophysiology of IBD: U. Seidler.20. Neutrophil Transepithelial Migration and Epithelial Barrier Function in IBD – Potential Targets for Inhibiting Neutrophil Trafficking: C.A. Parkos.Part V: GALT – Relevant for Regulation of Inflammation?:.21. Collaboration of Epithelial Cells With Organized Lymphoid Tissue: M.J. Kraehenbuhl.22. Role of Lymphotoxins in the Development of PP and MLN – Relevance to Intestinal Inflammation and Treatment: T.W. Spahn.23. Trafficking and Function of Mucosal Dendritic Cells: A. Iwasaki.24. Intraepithelial T-Cells – Implication for Intestinal Inflammation: M. Kronenberg.Part VI: Relevance of Microbial Factors – Additive Or Causative for IBD?:.25. Microbial – Epithelial Cell Crosstalk During Inflammation: The Host Response: M. Kagnoff.26. Role of Toll-Like Receptors in Orchestrating the Innate Immune Response – Potential Targets for Treatment?: D. Podolsky.27. Host-Bacterial Interactions in the Gut: Signalling by Commensal Flora: J. Gordon.28. Immunostimulatory DNA- Potential Therapeutics for Treatment of Enteric Inflammatory Disease?: E. Raz.29. Probiotics – Their Role in Controlling Intestinal Inflammation?: J.F. Colombel.30. Inflammatory Bowel Disease – Pandora's Box, Present and Future: J. Schölmerich.Index of Contributors