Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function

Andre Herchuelz and Mordecai P. Blaustein are the authors of Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function: Fifth International Conference, Volume 1099, published by Wiley.

• Preface: Andre Herchuelz. Historical Note Regarding the Discovery of the Na/Ca Exchanger and the PMCA: Andre Herchuelz.Part I: Structure–Function Relationships of the Exchanger:.1. What We Know about the Structure of NCX1 and How It Relates to Its Function: Debora A. Nicoll, Xiaoyan Ren, Michela Ottolia, Martin Phillips, Alfredo R. Paredes, Jeff Abramson, and Kenneth D. Philipson.2. Structural Basis for Ca2+ Regulation in the Na+/Ca2+ Exchanger: Mark Hilge, Jan Aelen, Anastassis Perrakis, and Andgeerten W. Vuister.3. Structure–Function Relationships of the NCKX2 Na+/Ca2+-K+ Exchanger: Y. Shibukawa, K.J. Kang, T.G. Kinjo, R.T. Szerencsei, H.F. Altimimi, P. Pratikhya, R.J. Winkfein, and P.P.M. Schnetkamp.4. Examining Ca2+ Extrusion of Na+/Ca2+-K+ Exchangers: Haider F. Altimimi and Paul P.M. Schnetkamp.5. Topologic Investigation of the NCKX2 Na+/Ca2+-K+ Exchanger α-Repeats: Tashi G. Kinjo, Robert T. Szerencsei, and Paul P.M. Schnetkamp.6. Transmembrane Segments I, II, and VI of the Canine Cardiac Na+/Ca2+ Exchanger Are in Proximity: Xiaoyan Ren, Debora A. Nicoll, and Kenneth D. Philipson.7. Effect of Ca2+ on Protein Kinase A-Mediated Phosphorylation of a Specific Serine Residue in an Expressed Peptide Containing the Ca2+-Regulatory Domain of Scallop Muscle Na+/Ca2+ Exchanger: C. Ryan, G. Shaw, and P.M.D. Hardwicke.Part II. Regulation of the Exchanger:.8. Regulation of the Cardiac Na+/Ca2+ Exchanger by Calcineurin and Protein Kinase C: Munekazu Shigekawa, Yuki Katanosaka, and Andshigeo Wakabayashi.9. New Modes of Exchanger Regulation: Physiological Implications: John P. Reeves, Madalina Condrescu, Jason Urbanczyk, and Olga Chernysh.10. Shedding Light on the Na+/Ca2+ Exchanger: Michela Ottolia, Scott John, Yi Xie, Xiaoyan Ren, and Kenneth D. Philipson.11. The Regulation of the Na/Ca Exchanger and Plasmalemmal Ca2+ ATPase by Other Proteins: Abdul M. Ruknudin and Edward G. Lakatta.12. Phosphorylation and Other Conundrums of Na/Ca Exchanger, NCX1: Abdul M. Ruknudin, Shao-Kui Wei, Mark C. Haigney, W.J. Lederer, and Dan H. Schulze.13. Regulation of Cardiac Na+/Ca2+ Exchanger by Phospholemman: Joseph Y. Cheung, Lawrence I. Rothblum, J. Randall Moorman, Amy L. Tucker, Jianliang Song, Belinda A. Ahlers, Lois L. Carl, Ju Fang Wang, and Xue-Qian Zhang.14. The Squid Preparation as a General Model for Ionic and Metabolic Na+/Ca2+ Exchange Interactions: Physiopathological Implications: R. Dipolo and L. Beauge.15. Some Biochemical Properties of the Upregulation of the Squid Nerve Na+/Ca2+ Exchanger by MgATP and Phosphoarginine: Graciela Berberian, Reinaldo Dipolo, and Luis Beauge.16. Ionic Selectivity of NCKX2, NCKX3, and NCKX4 for Monovalent Cations at K+-Binding Site: Ju-Young Lee, Won-Kyung Ho, and Suk-Ho Lee.17. In Bovine Heart Na+/Ca2+ Exchanger Maximal Ca2+ i Affinity Requires Simultaneously High pHi and PtdIns-4,5-P2 Binding to the Carrier: Velia Posada, Luis Beauge, and Graciela Berberian.18. NCX Current in the Murine Embryonic Heart: Development-Dependent Regulation by Na+: Michael Reppel, Hannes Reuter, Philipp Sasse, Jurgen Hescheler, and Bernd K. Fleischmann.19. Gender Differences in Na/Ca Exchanger Current and β-Adrenergic Responsiveness in Heart Failure in Pig Myocytes: Shao-Kui Wei, John M. McCurley, Stephen U. Hanlon, and Mark C.P. Haigney.20. Roles of NCX and PMCA in Basolateral Calcium Export Associated with Mineralization Cycles and Cold Acclimation in Crayfish: M.G. Wheatly, Y. Gao, L.M. Stiner, D.R. Whalen, M. Nade, F. Vigo, and A.E. Golshani.Part III: Na/Ca Exchanger Gene Regulation:.21. Modulation Pathways of NCX mRNA Stability: Involvement of RhoB: Sachiko Maeda, Isao Matsuoka, and Junko Kimura.22. Regulation of Ncx1 Gene Expression in the Normal and Hypertrophic Heart: Donald R. Menick, Ludivine Renaud, Avery Buchholz, Joachim G. Muller, Hongming Zhou, Christiana S. Kappler, Steven W. Kubalak, Simon J. Conway, and Lin Xu.23. Cyclosporin A-Dependent Downregulation of the Na+/Ca2+ Exchanger Expression: H. Rahamimoff, B. Elbaz, A. Alperovich, C. Kimchi-Sarfaty, M.M. Gottesman, Y. Lichtenstein, M. Eskin-Shwartz, and J. Kasir.Part IV: Cellular Location of the Exchanger:.24. Functional Significance of Na+/Ca2+ Exchangers Co-localization with Ryanodine Receptors: Anna A. Sher, Robert Hinch, Penelope J. Noble, David J. Gavaghan and Denis Noble.25. Three Types of Muscles Express Three Sodium–Calcium Exchanger Isoforms: Dmitri O. Levitsky.Part V: Structure–Function Relationship of the Plasma Membrane Ca2+-ATPase:.26. Plasma Membrane Ca2+ ATPases as Dynamic Regulators of Cellular Calcium Handling: Emanuel E. Strehler, Ariel J. Caride, Adelaida G. Filoteo, Yuning Xiong, John T. Penniston, and Agnes Enyedi.27. Functional Specificity of PMCA Isoforms?: Teuta Domi, Francesca Di Leva, Laura Fedrizzi, Alessandro Rimessi, and Marisa Brini.28. Plasma Membrane Calcium ATPase and Its Relationship to Nitric Oxide Signaling in the Heart: Elizabeth J. Cartwright, Delvac Oceandy, and Ludwig Neyses.29. Functional Importance of PMCA Isoforms in Growth and Development of PC12 Cells: Ludmila Zylinska, Anna Kozaczuk, Janusz Szemraj, Christos Kargas, and Iwona Kowalska.Part VI: NC(K)X and PMCA KO Mice:.30. Na+/Ca2+ Exchanger Knockout Mice: Plasticity of Cardiac Excitation–Contraction Coupling: Christian Pott, Scott A. Henderson, Joshua I. Goldhaber, and Kenneth D. Philipson.31. Distinct Phenotypes among Plasma Membrane Ca2+-ATPase Knockout Mice: Vikram Prasad, Gbolahan Okunade, Li Liu, Richard J. Paul, and Gary E. Shull.32. Role of Plasma Membrane Calcium ATPase Isoform 2 in Neuronal Function in the Cerebellum and Spinal Cord: Michael P. Kurnellas, Amanda K. Lee, Karolynn Szczepanowski, and Stella Elkabes.33. Increased Tolerance to Ischemic Neuronal Damage by Knockdown of Na+–Ca2+ Exchanger Isoform 1: Jing Luo, Yanping Wang, Xinzhi Chen, Hai Chen, Douglas B. Kintner, Gary E. Shull, Kenneth D. Philipson, and Dandan Sun.34. Resistance of Cardiac Cells to NCX Knockout: A Model Study: Denis Noble, Nobuaki Sarai, Penelope J. Noble, Tsutomu Kobayashi, Satoshi Matsuoka, and Akinori Noma.35. Homozygous Overexpression of the Na+–Ca2+ Exchanger in Mice: Evidence for Increased Transsarcolemmal Ca2+ Fluxes: Christian Pott, Joshua I. Goldhaber, and Kenneth D. Philipson.Part VII. Cardiac Function:.36. Na/Ca Exchange: Regulator of Intracellular Calcium and Source of Arrhythmias in the Heart: L.A. Venetucci, A.W. Trafford, S.C. O’Neill, and D.A. Eisner.37. Na:Ca Stoichiometry and Cytosolic Ca-Dependent Activation of NCX in Intact Cardiomyocytes: Donald M. Bers and Kenneth S. Ginsburg.38. Na/Ca Exchange and Cardiac Ventricular Arrhythmias: Karin R. Sipido, V. Bito, G. Antoons, Paul G. Volders, and Marc A. Vos.39. The Role of the Cardiac Na+/Ca2+ Exchanger in Reverse Remodeling: Relevance for LVAD–Recovery: Cesare M.N. Terracciano, Maren U. Koban, Gopal K. Soppa, Urszula Siedlecka, Joon Lee, Mark A. Stagg, and Magdi H. Yacoub.40. Regulation of Na+/Ca2+ Exchange Current in the Normal and Failing Heart: Michael Reppel, Bernd K. Fleischmann, Hannes Reuter, Frank Pillekamp, Heribert Schunkert, and Jurgen Hescheler.41. Phosphorylation of Na+/Ca2+ Exchanger in TAB-Induced Cardiac Hypertrophy: Yuki Katanosaka, Bongju Kim, Shigeo Wakabayashi, Satoshi Matsuoka, And Munekazu Shigekawa.42. Role of Ca2+ Transporters and Channels in the Cardiac Cell Volume Regulation: A. Takeuchi, S. Tatsumi, N. Sarai, K. Terashima, S. Matsuoka, and A. Noma.Part VIII: NCX and PMCA in Neuronal and Smooth Muscle Function:.43. NCX and NCKX Operation in Ischemic Neurons: Lech Kiedrowski.44. Na+/Ca2+ Exchange and Ca2+ Homeostasis in Axon Terminals of Mammalian Central Neurons: Suk-Ho Lee, Myoung-Hwan Kim, Ju-Young Lee, Sang Hun Lee, Doyun Lee, Kyeong Han Park, and Won-Kyung Ho.45. ncx1, ncx2, and ncx3 Gene Product Expression and Function in Neuronal Anoxia and Brain Ischemia: L. Annunziato, G. Pignataro, F. Boscia, R. Sirabella, L. Formisano, M. Saggese, O. Cuomo, R. Gala, A. Secondo, D. Viggiano, P. Molinaro, V. Valsecchi, A. Tortiglione, A. Adornetto, A. Scorziello, M. Cataldi, and G.F. Di Renzo.46. Sodium–Calcium Exchanger in Pulmonary Artery Smooth Muscle Cells: Yun-Min Zheng and Yong-Xiao Wang.47. Rapid Downregulation of NCX and PMCA in Hippocampal Neurons Following H2O2 Oxidative Stress: Sertac N. Kip and Emanuel E. Strehler.Part IX: Ca2+ Extruding Mechanisms and Apoptosis:.48. Cleavage of the Plasma Membrane Ca2+ATPase during Apoptosis: Katalin Paszty, Geza Antalffy, Luca Hegedus, Rita Padanyi, Alan R. Penheiter, Adelaida G. Filoteo, John T. Penniston, and Agnes Enyedi.49. The Plasma Membrane Na+/Ca2+ Exchanger Is Cleaved by Distinct Protease Families in Neuronal Cell Death: D. Bano, E. Munarriz, H.L. Chen, E. Ziviani, G. Lippi, K.W. Young, and P. Nicotera.50. Role of Na/Ca Exchange and the Plasma Membrane Ca2+–ATPase in β Cell Function and Death: Andre Herchuelz, Adama Kamagate, Helena Ximenes, and Francoise Van Eylen.51. Overexpression of Na/Ca Exchanger Reduces Viability and Proliferation of Gliosarcoma Cells: Evrard Nguidjoe and Andre Herchuelz.52. Redox Modulation of the Apoptogenic Activity of Thapsigargin: Claudia Cerella, Simona Coppola, Maria D'Alessio, Milena De Nicola, Andrea Magrini, Antonio Bergamaschi, and Lina Ghibelli.53. The Role of Na+/Ca+ Exchanger in Endothelin-1-Aggravated Hypoxia/Reoxygenation-Induced Injury in Renal Epithelial Cells: Satomi Kita, Ayako Furuta, Yukio Takano, and Takahiro Iwamoto.54. Involvement of Na+/Ca2+ Exchanger Type-1 in Ischemia-Induced Neovascularization in the Mouse Hindlimb: Yukiko Matsui, Satomi Kita, Takeshi Katsuragi, Issei Komuro, Takahiro Iwamoto, and Hiroyuki Ohjimi.55. The Na+/Ca2+ Exchanger Isoform 3 (NCX3) but Not Isoform 2 (NCX2) and 1 (NCX1) Singly Transfected in BHK Cells Plays a Protective Role in a Model of in Vitro Hypoxia: Agnese Secondo, Ilaria Rosaria Staiano, Antonella Scorziello, Rossana Sirabella, Francesca Boscia, Annagrazia Adornetto, Lorella Maria Teresa Canzoniero, Gianfranco Di Renzo, and Lucio Annunziato.56. Involvement of the Potassium-Dependent Sodium/Calcium Exchanger Gene Product NCKX2 in the Brain Insult Induced by Permanent Focal Cerebral Ischemia: Ornella Cuomo, Giuseppe Pignataro, Rosaria Gala, Francesca Boscia, Anna Tortiglione, Pasquale Molinaro, Gianfranco Di Renzo, Jonathan Lytton, Andlucio Annunziato.Part X: Na/Ca Exchange in the Endoplasmic Reticulum, the Mitochondria, and the Nuclear Envelope:.57. Analysis of Calcium Changes in Endoplasmic Reticulum during Apoptosis by the Fluorescent Indicator Chlortetracycline: Claudia Cerella, Cristina Mearelli, Milena De Nicola, Maria D'Alessio, Andrea Magrini, Antonio Bergamaschi, and Lina Ghibelli.58. Sodium–Calcium Exchangers in the Nucleus: An Unexpected Locus and an Unusual Regulatory Mechanism: Robert W. Ledeen and Gusheng Wu.59. Mitochondrial Ca2+ Flux through Na+/Ca2+ Exchange: Bongju Kim and Satoshi Matsuoka.60. Non-apoptogenic Ca2+-Related Extrusion of Mitochondria in Anoxia/Reoxygenation Stress: Annalisa Dorio, Claudia Cerella, Milena De Nicola, Maria D'Alessio, Giampiero Gualandi, and Lina Ghibelli.Part XI. Na/Ca Exchange Inhibitors: Therapeutic Opportunities:.61. Na+/Ca2+ Exchange as a Drug Target—Insights from Molecular Pharmacology and Genetic Engineering: Takahiro Iwamoto.62. Inhibitory Mechanism of SN-6, A Novel Benzyloxyphenyl Na+/Ca2+ Exchange Inhibitor: Satomi Kita and Takahiro Iwamoto.63. Electrophysiological Effects of SN-6, a Novel Na+/Ca2+ Exchange Inhibitor on Membrane Currents in Guinea Pig Ventricular Myocytes: Chun-Feng Niu, Yasuhide Watanabe, Takahiro Iwamoto, Kanna Yamashita, Hiroshi Satoh, Tuyoshi Urushida, Hideharu Hayashi, and Junko Kimura.Position Paper.64. Directionality in Drug Action on Sodium–Calcium Exchange: D. Noble And M. P. Blaustein.Index of Contributors