Thymosins in Health and Disease II

Allan L. Goldstein is professor and Catharine B. & William McCormick Chair of the department of Biochemistry and Molecular Biology at The George Washington University School of Medicine and Health Sciences, where he has served since 1978. He is a world-renowned authority on the thymus gland and the workings of the immune system, and co-discoverer of the thymosins.Dr. Goldstein is the author of over 400 scientific articles in professional journals, the inventor on more than 15 U.S. Patents, and the editor of several books in the fields of biochemistry, biomedicine, immunology and neuroscience.He is on the editorial boards of numerous scientific and medical journals and has been a consultant to many research organizations in industry and government; co-founder of The Institute for Advanced Studies in Aging and Geriatric Medicine, a non-profit research and educational institute; a member of the Board of Trustees of the Albert Sabin Vaccine Institute; and serves as the Chairman of the Board of RegeneRx Biopharmaceuticals.Dr. Goldstein received his B.S. from Wagner College in 1959 and his M.S. and Ph.D. from Rutgers University in 1964. He served as a faculty member of the Albert Einstein College of Medicine from 1964 to 1972, and moved to the University of Texas Medical Branch in Galveston in 1972 as professor and director of the division of Biochemistry.

• Introduction for Thymosins in Health and Disease viiAllan I. Goldstein and Enrico GaraciThymosin α1: immunomodulation, immunopharmacology, infectious diseases, and cancersThymosin α1: a novel therapeutic option for patients with refractory chronic purulent rhinosinusitis 1Virgil A. S. H. Dalm, Harm de Wit and Hemmo A. DrexhageThymosin α1: in melanoma: from the clinical trial setting to the daily practice and beyond 8Riccardo Danielli, Ester Fonsatti, Luana Calabrò, Anna Maria Di Giacomo and Michele MaioThymosin α1 as a stimulatory agent of innate cell-mediated immune response 13Annalucia Serafino, Pasquale Pierimarchi, Francesca Pica, Federica Andreola, Roberta Gaziano, Noemi Moroni, Manuela Zonfrillo, Paola Sinibaldi-Vallebona and Enrico GaraciThymosin α1 continues to show promise as an enhancer for vaccine response 21 Cynthia Tuthill, Israel Rios, Alfonso De Rosa and Roberto CameriniClinical and preclinical applications of thymosin β4: wound healing, eye injuries, cardiovascular diseases, and neurological injuriesThe use of angiogenic-antimicrobial agents in experimental wounds in animals: problems and solutions 28Paritosh Suman, Harikrishman Ramachandran, Sossy Sahakian, Kamraan Z. Gill, Basil A. J. Horst, Shanta M. Modak and Mark A. HardyThe regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients 37Terry Treadwell, Hynda K. Kleinman, David Crockford, Mark A. Hardy, Georgio T. Guarnera and Allan L. GoldsteinThymosin β4: a potential novel dry eye therapy 45 Gabriel Sosne, Ping Qiu, George W. Ousler 3rd, Steven P. Dunn and David CrockfordNeuroprotective and neurorestorative effects of thymosin β4 treatment following experimental traumatic brain injury 51Ye Xiong, Asim Mahmood, Yuling Meng, Yanlu Zhang, Zheng Gang Zhang, Daniel C. Morris and Michael ChoppUse of the cardioprotectants thymosin β4 and dexrazoxane during congenial heart surgery: proposal for a randomized, double-blind, clinical trial 59Daniel Stromberg, Tia Raymond, David Samuel, David Crockford, William Stigall, Steven Leonard, Eric Mendeloff and Andrew GormleyCardiac repair with thymosin β4 and cardiac reprogramming factors 66Deepak Srivastava, Masaki Ieda, Jidong Fu and Li QianLate breaking paper sessionNMR structural studies of thymosin α1 and β-thymosins 73 David E. Volk, Cynthia W. Tuthill, Miguel-Angel Elizondo-Riojas and David G. GorensteinFragments of β-thymosin from the sea urchin Paracentrotus lividus as potential antimicrobial peptides against staphylococcal biofilms 79Domenico Schillaci, Maria Vitale, Maria Grazia Cusimano and Vincenzo ArizzaDevelopment of an analytical HPLC methodology to study the effects of thymosin β4 on actin in sputum of cystic fibrosis patients 86Mahnaz Badamchain, Ali A. Damavandy and Allan L. GoldsteinThe role of biologically active peptides in tissue repair using umbilical cord mesenchymal stem cells 93Carlos Cabrera, Gabriela Carriquiry, Chiara Pierinelli, Nancy Reinoso, Javier Arias-Stella and Javier PainoIdentification on interaction partners of β-thymosins: applications of thymosin β4 labeled by transglutaminase 98Christine App, Jana Knop, Hans Georg Mannherz and Ewald HannappelAntibodies in research of thymosin β4: investigation of cross-reactivity and influence of fixatives 105Jana Knop, Christine App and Ewald HannappelThymosin β4 sustained release from poly(lactide-co-glycolide) microspheres: synthesis and implications for treatment of myocardial ischemia 112 Jeffrey E. Thatcher, Tré Welch, Robert C. Eberhart, Zoltan A. Schelly and J. Michael DiMaio