Cutaneous Melanoma, Fifth Edition

Charles Balch Professor of Surgery, Oncology, and Dermatology, Johns Hopkins School of Medicine; Deputy Director for Clinical Trials and Outcomes Research, Institute for Clinical and Translational Research, Johns Hopkins Medical Institutions, Baltimore, Maryland. Alan Houghton, Vice Chairman, Member, Department of Medicine and Immunology; Professor of Immunology, Gerstner Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York. Arthur Sober, Professor, Department of Dermatology, Harvard Medical School; Director, Medical Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Seng-jaw Soong, Professor Emeritus of Medicine, Department of Medicine; Director Emeritus, Biostatistics and Bioinformatics Unit; Associate Director Emeritus of the Comprehensive Cancer Center, University of Alabama at Birmingham. Michael Atkins, Professor of Medicine, Harvard Medical School; Deputy Chief, Division of Hematology/Oncology; Director, Cancer Clinical Trials Office and Cutaneous Oncology Program, Beth Israel Deaconess Medical Center, Boston. John Thompson, Professor of Melanoma and Surgical Oncology, Discipline of Surgery, Faculty of Medicine, the University of Sydney; Director, Sydney Melanoma Unit and Melanoma Institute Australia, Royal Prince Alfred and Mater Hospitals, Sydney, Australia.

"This is the fourth edition of the book that is no doubt the premier text on cutaneous melanoma. The book is oriented to all health care workers and researchers involved in the care of patients with melanomas. This includes, but is not limited to, the dermatologist, medical oncologist, surgical oncologist, radiation oncologist, and cosmetic surgeons, as well as nurses and other practitioners who diagnose or treat patients with melanoma. The 73 distinguished contributors have combined to put together 39 chapters in 7 parts or sections. ...The photos are outstanding and the information invaluable. The book belongs in every physician’s library, whatever his or her specialty, to raise awareness of the deadly disease."—The American Journal of Cosmetic Surgery"Overall, the text is easy to use and well indexed. I find that it is my reference text of choice for any melanoma-related questions that arise during the day. The authors should be commended for their fine and highly accessible work."—American Society for Dermatologic Surgery"…should serve as an invaluable source of information to all clinicians involved in the care of patients with malignant melanoma and to basic scientists who want to become more familiar with various clinical aspects of the disease. I intend to keep it on my desk and refer to it in my practice." —Journal of the American Medical Association

• INTRODUCTION, 1 A History of Melanoma: From Hunter to Milton PART I EPIDEMIOLOGY, PROGNOSIS, AND STAGING 2 Epidemiology of Melanoma 3 Prognostic Factors and Natural History of Melanoma 4 Melanoma Staging and Classification 5 Models for Predicting Melanoma Outcome PART II SCREENING: CLINICAL ASSESSMENT AND PATHOLOGY 6 Melanoma Prevention and Screening 7 Clinical Genetics and Risk Assessment of Melanoma 8 Acquired Precursor Lesions and Phenotypic Markers of Increased Risk for Cutaneous Melanoma 9 Clinical Characteristics of Melanoma 10 Biopsy of Suspected Melanomas 11 Pathology of Melanoma PART III MANAGEMENT OF LOCALIZED MELANOMA 12 Excision of Primary Melanoma 13 Complex Closures of Melanoma Excisions 14 Local Recurrences of Melanoma and Their Management 15 Mucosal Melanoma 16 Melanoma in Children and Teenagers 17 Pregnancy and the Use of Hormones in Melanoma Patients PART IV MANAGEMENT OF REGIONAL METASTASES 18 The Sentinel Lymph Node and Regional Melanoma Micrometastases 19 Lymphoscintigraphy in Patients With Melanoma 20 Intraoperative Mapping and Sentinel Node Technology in Patients With Melanoma 21 Axillary and Epitrochlear Lymph Node Dissection for Melanoma 22 Inguinofemoral, Iliac/Obturator, and Popliteal Lymphadenectomy in Patients With Melanoma 23 Neck Dissection and Parotidectomy for Melanoma 24 Recurrent Regional Metastases of Melanoma 25 Radiotherapy for Primary and Regional Melanoma 26 Hyperthermic Regional Perfusion for Melanoma of the Limbs 27 Isolated Limb Infusion for Melanoma PART V DIAGNOSIS AND LOCAL TREATMENT OF DISTANT METASTASES 28 Metastatic Surveillance and Follow-up of Melanoma Patients 29 Diagnosis of Stage IV Melanoma 30 Surgical Excision of Distant Melanoma Metastases 31 Radiotherapy for Distant Metastases and Clinical Radiobiology of Melanoma 32 Multidisciplinary Management of CNS Melanoma Metastases PART VI SYSTEMIC TREATMENT OF METASTATIC DISEASE 33 Adjuvant Systemic Therapy for High-Risk Melanoma Patients 34 Chemotherapy-Based Treatment of Metastatic Melanoma 35 Interferon Therapy for Melanoma 36 Interleukins and Cellular Therapies for Melanoma 37 Melanoma Vaccines 38 Immune Modulators in the Treatment of Patients With Melanoma 39 Melanoma-Specific Targeted Therapies PART VII BIOLOGY OF MELANOMA 40 Genetics and Molecular Pathology of Melanoma 41 Biology of Melanocytes and Primary Melanoma 42 Biology of Melanoma Metastasis 43 Immunology of Melanoma 44 Biomarkers for Melanoma