Melanocortin Receptors

Häftad, Engelska, 2010

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Beskrivning

Roger Cone and a distinguished team of expert investigators provide the first major treatment of this critically important receptor family. The book illuminates the structure and function of these receptors through a wide-ranging review of the latest findings concerning the biology, physiology, and pharmacology of their peptide ligands and covers the major melanocortin peptides, Melanocortin-1-Receptors through Melanocortin-5-Receptors. Topics include the characterization of the melanocortin receptors, the biochemical mechanism of receptor action, and receptor function and regulation. Timely and authoritative, The Melanocortin Receptors offers an up-to-date knowledge base on the remarkably complex structure and functions of the melanocortins, a guide that will prove invaluable for today's neuroscientists, endocrinologists, pharmacologists, and other clinical and experimental investigators working in this fast moving field.

Produktinformation

Utgivningsdatum:2010-12-08
Mått:152 x 229 x 31 mm
Vikt:806 g
Format:Häftad
Språk:Engelska
Serie:Receptors
Antal sidor:542
Förlag:Humana Press Inc.
ISBN:9781617370823

Utforska kategorier

Medicin: allmänt inom Medicin
Endokrinologi inom Medicin

Recensioner i media

"New data on melanocortin receptors 1-5 and their regulation are the topic of several chapters. A complete, well referenced text of interest to all endocrinologists, neuroscientists, geneticists, physiologists and pharmacologists." - Journal of Pediatric Endocrinology & Metabolism

Innehållsförteckning

I. Historical Perspectives.- 1 • Proopiomelanocortin and the Melanocortin Peptides.- 2 • Melanocortins and Pigmentation.- 3 • Melanocortins and Adrenocortical Function.- 4 • Effects of Melanocortins in the Nervous System.- 5 • Peripheral Effects of Melanocortins.- II. Characterization of the Melanocortin Receptors.- 6 • Melanocortin Receptor Expression and Function in the Nervous System.- 7 • Cloning of the Melanocortin Receptors.- III. Biochemical Mechanism of Receptor Action.- 8 • The Molecular Pharmacology of Alpha-Melanocyte Stimulating Hormone: Structure Activity Relationships for Melanotropins at Melanocortin Receptors.- 9 • In Vitro Mutagenesis Studies of Melanocortin Receptor Coupling and Ligand Binding.- IV. Receptor Function.- 10 • The Melanocortin-1 Receptor.- 11 • The Human Melanocortin-1 Receptor.- 12 • The Melanocortin-2 Receptor in Normal Adrenocortical Function and Familial Adrenocorticotropic Hormone Resistance.- 13 • The Melanocortin-3 Receptor.- 14 • The Melanocortin-4 Receptor.- 15 • The Melanocortin-5 Receptor.- V. Receptor Regulation.- 16 • Regulation of the Melanocortin Receptors by Agouti.- 17 • Melanocortins and Melanoma.- 18 • Regulation of the Mouse and Human Melanocortin-1 Receptor.- VI. Future Vistas.- 19 • Future Vistas.