Platinum-Based Drugs in Cancer Therapy

This volume of the Cancer Drug Discovery and Development series provides comprehensive coverage of some of the basic science associated with cisplatin, its interaction with DNA and how recognitions and processing of platinum-DNA adducts may be associated with tumour response or resistance. ...Bringing together the most recent research in the area of platinum drugs...The editors of this book have produced a collection of articles which will be of interest to those who need an introduction to the field of platinum drugs. For anyone already familiar with the field, the chapters on the newer analogues and on some of the more recent basic molecular pharmacology issues will provide a useful update. -The Lancet "The great attention is also paid to all toxicological aspects of platinum drugs from both clinical and regulatory perspective... The Platinum-based Drugs in Cancer Therapy appears to be a comprehensive book useful for scientist, medical oncologist and pharmacist seeking answer on specific questions concerning preclinical and clinical data of platinum drugs."-Neoplasma "The strength of the text lies in the diversity of topics that are covered in such a succinct fashion. Clinicians will benefit from the earlier focus on basic chemistry and biochemistry, while the bench scientist will better appreciate the practicalities of using these compounds from the lucid experiences of the clinical case studies."-Journal of Medicinal Chemistry "This is a useful reference book for scientists and practitioners who have a focus or interest in the chemistry and biochemistry of the platinum compounds. Oncologists will find it helpful for its summary of applications of cisplatin and carboplatin, especially in combination with paclitaxel."--Oncology Journal, November, 2000 "...the book should find its place in the library of many laboratories involved mainly in preclinical oncological research."-Annals of Oncology "This new book by Kelland and Farrell is a well-constructed and authoritative account of current knowledge concerning the pharmacology and clinical application of platinum anticancer drugs. It is well illustrated with clear diagrams and appropriate data. ...Not only do platinum agents remain a key component of current cancer therapy for the majority of common solid tumours but recent advances have demonstrated the scope for expansion of the clinical spectrum of activity, the ability to overcome resistance, and the potential introduction of oral delivery." - Clinical Oncology

• I: Platinum Chemistry.- 1 The Chemistry of Cisplatin in Aqueous Solution.- 2 Chemistry and Structural Biology of 1,2-Interstrand Adducts of Cisplatin.- 3 Transplatin-Modified Oligonucleotides as Potential Antitumor Drugs.- II: Platinum Biochemistry.- 4 Cisplatin Accumulation.- 5 Cisplatin Resistance in Ovarian Cancer: Mismatch Repairand Engagement of Apoptosis.- 6 DNA Adduct Tolerance and Bypass.- 7 How Does Cisplatin Kill Cells?.- III: Clinical Antitumor Activity and Toxicology of Platinum Drugs.- 8 Clinical Experience with Cisplatin and Carboplatin.- 9 Clinical Experience: Platinum and Taxanes.- 10 Clinical Experience: DACH-Based Platinum Drugs.- 11 Clinical Toxicology of Platinum-Based Cancer Chemotherapeutic Agents.- 12 Toxicology and Regulatory Aspects of Platinum Drugs.- IV: New Platinum Drugs of the Future.- 13 New Platinum Drugs: The Pathway to Oral Therapy.- 14 Polynuclear Charged Platinum Compounds as a New Class of Anticancer Agents: Toward a New Paradigm.