"In this volume of Principles of Molecular Regulation, one has the opportunity to survey the state of membrane receptor initiated cell signaling and nuclear receptor initiated gene regulation from viewpoints of a selected cadre of leading investigators...the reader can savor the current progress and excitement in this vibrant field of molecular endocrinology." -Bert W. O'Malley "...has made a brave attempt to give the reader a bird's eye-view on all the possible molecular signals that cells receive, all the different mechanisms to which cells respond and the errors made by cells during signaling that could lead to disease or death. The book, enriched with diagrams of the concepts discussed, is divided into six parts, and should be an excellent source of facts and reference for teachers, researchers and physicians working in many different areas of biology and medicine...The organization of the six different themes makes this a good textbook for course on signal transduction at the senior undergraduate or graduate level...this book is a valuable addition to the field of signal transduction and the authors and editors must be applauded for a job well done." - TRENDS in Endocrinology & Metabolism "...the volume provides background and breadth absent from typical reviews. It could serve as an excellent textbook for a graduate-level course and will be a valuable resource for investigators interested in cell signaling."- Patricia M. Hinkle "This book constitutes a new resource for understanding the many and complex elements of biological regulation. In this volume, the authors have assembled a panel of leading investigators to provide an integrated review of the key areas." - Lavoisier Librairie "For the established cell biologist, this book will provide some useful insights especially in fields just off the readers' regular patch." -Cell Biology International "A clearly written, richly illustrated, amply referenced volume describing the latest on the regulation of hormone action. A highly recommended book, not only to endocrine researchers and teachers but to all curious endocrinologists who want, beyond practice, to understand the basic science of endocrinology." -Journal of Pediatric Endocrinology and Metabolism "...presents state-of-the-art technology for DNA analysis...it offers a comprehensive and modern guide to the fast, reliable, and powerful technologies for the analysis of DNA variation. We are looking forward to having the second volume of the series." -Die Pharmazie "This book describes extensively some of the fundamental aspects of living organisms such as membrane receptor initiated cell signaling, nuclear receptor initiated gene regulation or molecular regulation of cell proliferation ... Throughout the text is supplemented with several comprehensive tables and figures. It is therefore intended not only for research workers familiar with some aspects of regulation, but also to students wanting to learn more about basic concepts of signaling mechanisms. In conclusion, this book surveys the current state and perspectives of cell signaling and gene regulation, and should be recommended to all those interested in the process of life and its mechanisms of regulation at the molecular level." - Biochimie

• Part I. Signaling Mechanisms Initiated by Cell Surface Receptors. G Protein-Coupled Receptors and G Proteins, Alfredo Ulloa-Aguirre and P. Michael Conn. G-Proteins Large and Small Guanine Nucleotide Binding Proteins: Cellular Communication Networks, Thomas M. Wilkie and Michael White. The Insulin Receptor Kinase: Regulation and Therapeutic Significance, Barry I. Posner. Growth Hormone Action: Signaling via a JAK/STAT-Coupled Receptor, David J. Waxman and Stuart J. Frank. Regulation of Drosophila Visual Transduction Through a Supramolecular Signaling Complex, Craig Montell. Dictyostelium: A Model Experimental System for Elucidating the Pathways and Mechanisms Controlling Chemotaxis, Chang Y. Chung and Richard A. Firtel. gp130-Related Cytokines, Christoph J. Auernhammer and Shlomo Melmed. Part II. Signaling Mechanisms Mediated by Ion Channels Calcium and Lipids. Ion Channels, Deborah J. Nelson and Harry A. Fozzard. Calcium Ions as Intracellular Messengers: Pathways and Actions, Stanko S. Stojilkovic, Melanija Tomic´, Taka-aki Koshmimizu, and Fredrick Van Goor. Calcium and Calmodulin-Mediated Regulatory Mechanisms, Anthony R. Means. Protein Kinase C, Alexandra C. Newton. Nitric Oxide, Randy Krainock and Sean Murphy. Phospholipids, J. H. Exton. Part III. Cyclic AMP, Protein Kinases and Protein Phosphatases. Adenylyl Cyclases, Lutz Birnbaumer. Cyclic Nucleotide Phosphodiesterases, Marco Conti. Cyclic Nucleotide-Dependent Protein Kinases, Sharron H. Francis and Jackie D. Corbin. Protein Serine/Threonine Kinases, Jörn Heierhorst, Richard Pearson, James Horne, Steven Bozinovski, Bostjan Kobe, and Bruce E. Kemp. Protein Serine/Threonine Phosphatases, Shirish Shenolikar. Protein Tyrosine Phosphatases, Cynthia V. Stauffacher and Harry Charbonneau. Part IV. Signaling MechanismsInitiated by Nuclear Receptors. The Mechanism of Action of Steroid Hormone Receptors, Donald P. McDonnell. Orphan Receptors, Deepak S. Lala and Richard A. Heyman. Coactivators and Corepressors, Neil J.McKenna, Zafar Nawaz, Sophia Y. Tsai, and Ming-Jer Tsai. CREB Binding Protein-Coactivator Complexes, Riki Kurokawa and Christopher K. Glass. Part V. Molecular Regulation of Cell Proliferation and Death. Cell Cycle Checkpoints, Sally Kornbluth. Molecular Regulation of Apotosis, Rosemary B. Evans-Storms and John A. Cidlowski. T-Cells and Immunosuppression, Andrew W. Taylor. Part VI. Rational Drug Discovery. Rational Drug Discovery and the Impact of New Advanced Technologies, Jonathan Greer. Index.

"In this volume of Principles of Molecular Regulation, one has the opportunity to survey the state of membrane receptor initiated cell signaling and nuclear receptor initiated gene regulation from viewpoints of a selected cadre of leading investigators...the reader can savor the current progress and excitement in this vibrant field of molecular endocrinology." -Bert W. O'Malley "...has made a brave attempt to give the reader a bird's eye-view on all the possible molecular signals that cells receive, all the different mechanisms to which cells respond and the errors made by cells during signaling that could lead to disease or death. The book, enriched with diagrams of the concepts discussed, is divided into six parts, and should be an excellent source of facts and reference for teachers, researchers and physicians working in many different areas of biology and medicine...The organization of the six different themes makes this a good textbook for course on signal transduction at the senior undergraduate or graduate level...this book is a valuable addition to the field of signal transduction and the authors and editors must be applauded for a job well done." - TRENDS in Endocrinology & Metabolism "...the volume provides background and breadth absent from typical reviews. It could serve as an excellent textbook for a graduate-level course and will be a valuable resource for investigators interested in cell signaling."- Patricia M. Hinkle "This book constitutes a new resource for understanding the many and complex elements of biological regulation. In this volume, the authors have assembled a panel of leading investigators to provide an integrated review of the key areas." - Lavoisier Librairie "For the established cell biologist, this book will provide some useful insights especially in fields just off the readers' regular patch." -Cell Biology International "A clearly written, richly illustrated, amply referenced volume describing the latest on the regulation of hormone action. A highly recommended book, not only to endocrine researchers and teachers but to all curious endocrinologists who want, beyond practice, to understand the basic science of endocrinology." -Journal of Pediatric Endocrinology and Metabolism "...presents state-of-the-art technology for DNA analysis...it offers a comprehensive and modern guide to the fast, reliable, and powerful technologies for the analysis of DNA variation. We are looking forward to having the second volume of the series." -Die Pharmazie "This book describes extensively some of the fundamental aspects of living organisms such as membrane receptor initiated cell signaling, nuclear receptor initiated gene regulation or molecular regulation of cell proliferation ... Throughout the text is supplemented with several comprehensive tables and figures. It is therefore intended not only for research workers familiar with some aspects of regulation, but also to students wanting to learn more about basic concepts of signaling mechanisms. In conclusion, this book surveys the current state and perspectives of cell signaling and gene regulation, and should be recommended to all those interested in the process of life and its mechanisms of regulation at the molecular level." - Biochimie

• Part I. Signaling Mechanisms Initiated by Cell Surface Receptors. G Protein-Coupled Receptors and G Proteins, Alfredo Ulloa-Aguirre and P. Michael Conn. G-Proteins Large and Small Guanine Nucleotide Binding Proteins: Cellular Communication Networks, Thomas M. Wilkie and Michael White. The Insulin Receptor Kinase: Regulation and Therapeutic Significance, Barry I. Posner. Growth Hormone Action: Signaling via a JAK/STAT-Coupled Receptor, David J. Waxman and Stuart J. Frank. Regulation of Drosophila Visual Transduction Through a Supramolecular Signaling Complex, Craig Montell. Dictyostelium: A Model Experimental System for Elucidating the Pathways and Mechanisms Controlling Chemotaxis, Chang Y. Chung and Richard A. Firtel. gp130-Related Cytokines, Christoph J. Auernhammer and Shlomo Melmed. Part II. Signaling Mechanisms Mediated by Ion Channels Calcium and Lipids. Ion Channels, Deborah J. Nelson and Harry A. Fozzard. Calcium Ions as Intracellular Messengers: Pathways and Actions, Stanko S. Stojilkovic, Melanija Tomic´, Taka-aki Koshmimizu, and Fredrick Van Goor. Calcium and Calmodulin-Mediated Regulatory Mechanisms, Anthony R. Means. Protein Kinase C, Alexandra C. Newton. Nitric Oxide, Randy Krainock and Sean Murphy. Phospholipids, J. H. Exton. Part III. Cyclic AMP, Protein Kinases and Protein Phosphatases. Adenylyl Cyclases, Lutz Birnbaumer. Cyclic Nucleotide Phosphodiesterases, Marco Conti. Cyclic Nucleotide-Dependent Protein Kinases, Sharron H. Francis and Jackie D. Corbin. Protein Serine/Threonine Kinases, Jörn Heierhorst, Richard Pearson, James Horne, Steven Bozinovski, Bostjan Kobe, and Bruce E. Kemp. Protein Serine/Threonine Phosphatases, Shirish Shenolikar. Protein Tyrosine Phosphatases, Cynthia V. Stauffacher and Harry Charbonneau. Part IV. Signaling MechanismsInitiated by Nuclear Receptors. The Mechanism of Action of Steroid Hormone Receptors, Donald P. McDonnell. Orphan Receptors, Deepak S. Lala and Richard A. Heyman. Coactivators and Corepressors, Neil J.McKenna, Zafar Nawaz, Sophia Y. Tsai, and Ming-Jer Tsai. CREB Binding Protein-Coactivator Complexes, Riki Kurokawa and Christopher K. Glass. Part V. Molecular Regulation of Cell Proliferation and Death. Cell Cycle Checkpoints, Sally Kornbluth. Molecular Regulation of Apotosis, Rosemary B. Evans-Storms and John A. Cidlowski. T-Cells and Immunosuppression, Andrew W. Taylor. Part VI. Rational Drug Discovery. Rational Drug Discovery and the Impact of New Advanced Technologies, Jonathan Greer. Index.